Nanoporous siloxane membranes for ultrasound mediated ophthalmic drug delivery. This project will develop tailored polymers for use in a novel non-invasive ocular drug delivery device which treats vision threatening conditions such as age-related macular degeneration (AMD). The outcomes of this project will enable an entirely new ocular drug delivery technology, thereby delivering significant benefit to ophthalmic healthcare.
Flipping the mattress: infinite polyurethane recycling by synthetic biology. Australia is covered in billions of tonnes of plastic and yet <10% is recycled today. Polyurethane (PU) is ubiquitous in our everyday lives, from lacquer coatings to elastane clothing to durable foam padding in car seats, cushions and mattresses. Currently, there are few avenues for PU recycling and much ends up in landfill e.g., a single mattress produces 15-20kg of PU foam waste. Luckily, biodegradation of PU can occu ....Flipping the mattress: infinite polyurethane recycling by synthetic biology. Australia is covered in billions of tonnes of plastic and yet <10% is recycled today. Polyurethane (PU) is ubiquitous in our everyday lives, from lacquer coatings to elastane clothing to durable foam padding in car seats, cushions and mattresses. Currently, there are few avenues for PU recycling and much ends up in landfill e.g., a single mattress produces 15-20kg of PU foam waste. Luckily, biodegradation of PU can occur naturally via various microbial means and from insects, like Galleria mellonella larvae. The overall aim of this research project is to understand plastic biodegradation and translate nature’s solutions into flexible and efficient synthetic enzyme technologies that can sustainably recycle commonly used PU foams. Read moreRead less
Advanced Materials from Automated Synthesis of Sequence-Defined Polymers. The project aims to develop industrially scalable and environmentally friendly methods for synthesis of sequence-defined multiblock copolymers (polymer chains containing segments of different polymer types) using automated synthesis methods. The materials to be explored will be largely based on renewable biomass-derived monomeric building blocks. Such polymers are able to undergo microphase separation into spatially period ....Advanced Materials from Automated Synthesis of Sequence-Defined Polymers. The project aims to develop industrially scalable and environmentally friendly methods for synthesis of sequence-defined multiblock copolymers (polymer chains containing segments of different polymer types) using automated synthesis methods. The materials to be explored will be largely based on renewable biomass-derived monomeric building blocks. Such polymers are able to undergo microphase separation into spatially periodic compositional patterns, thereby providing access to a vast range of nano-engineered materials. This would enable design and synthesis of new advanced materials, making use of renewable resources and supporting the circular economy, with diverse potential applications ranging from nanomedicine to materials science.Read moreRead less
New Biomimetic Nanostructured Coatings for Hip Implants. Over 30,000 hip implants operations take place in Australia each year, due largely to a significant and growing proportion of the population suffering from conditions such as osteoporosis. The coating on the implants, required to cause good bone ingrowth and adhesion between bone and implant, is far from perfect. We propose to spray coatings which mimic the structure of bone, and thus offer improved mechanical properties such as appropriat ....New Biomimetic Nanostructured Coatings for Hip Implants. Over 30,000 hip implants operations take place in Australia each year, due largely to a significant and growing proportion of the population suffering from conditions such as osteoporosis. The coating on the implants, required to cause good bone ingrowth and adhesion between bone and implant, is far from perfect. We propose to spray coatings which mimic the structure of bone, and thus offer improved mechanical properties such as appropriate rigidity and toughness, and stimulate better bone growth at the interface. In this way the implant should be much longer lasting and the need for undesirable revision surgery reduced. The processing technique proposed could also be a useful platform coating technology in a number of other industries.Read moreRead less
Design and Fabrication of Molecular Machines: the Nanomachines of the Future. Nanotechnology that incorporates the use of nanomachines and molecular machines is an exciting new area of translational research, with broad potential in biomedical technology and industrial applications. We are developing new molecular machines and optimising their assembly. Recent innovation in the world of nanotechnology concerns the design and manufacture of synthetic and hybrid machines, based on existing biologi ....Design and Fabrication of Molecular Machines: the Nanomachines of the Future. Nanotechnology that incorporates the use of nanomachines and molecular machines is an exciting new area of translational research, with broad potential in biomedical technology and industrial applications. We are developing new molecular machines and optimising their assembly. Recent innovation in the world of nanotechnology concerns the design and manufacture of synthetic and hybrid machines, based on existing biological molecular machines but incorporating synthetic parts. Australia has an opportunity to be at the forefront of these new developments in nanotechnology, with a new generation of Australian scientists being trained across the foundation disciplines of chemistry, physics and molecular biology.Read moreRead less
A Novel Optical Source for the Vaporization and Deposition of Polymers. Thin polymer films are used widely in industrial processes and, hence, new techniques for producing such films are increasingly important. This project develops new optical technology required before a novel process for depositing polymers from the vapour phase can be widely explored for industrial applications. This project will enhance the capacity of Australian science in this important area of technology and could benefi ....A Novel Optical Source for the Vaporization and Deposition of Polymers. Thin polymer films are used widely in industrial processes and, hence, new techniques for producing such films are increasingly important. This project develops new optical technology required before a novel process for depositing polymers from the vapour phase can be widely explored for industrial applications. This project will enhance the capacity of Australian science in this important area of technology and could benefit the Australian economy by developing a novel commercial technology based on cutting-edge Australian research. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560758
Funder
Australian Research Council
Funding Amount
$187,000.00
Summary
Dynamics at Interfaces: a facility for the characterisation of the dynamics of structural reorganisation and adsorption at interfaces. Controlling the flow, stability, and general performance of finely dispersed materials is important in a great number of industries from cosmetics to minerals purification. These properties are often controlled by the addition of material that forms a film at the interface between the dispersed material and the solvent. We seek to develop a facility that will ena ....Dynamics at Interfaces: a facility for the characterisation of the dynamics of structural reorganisation and adsorption at interfaces. Controlling the flow, stability, and general performance of finely dispersed materials is important in a great number of industries from cosmetics to minerals purification. These properties are often controlled by the addition of material that forms a film at the interface between the dispersed material and the solvent. We seek to develop a facility that will enable the properties of this film to be characterized, in particular the rate at which the film responds to mechanical and chemical changes. With this knowledge we hope to relate the nanoscopic properties of the adsorbed film to macroscopic properties of the dispersion and be able to tune the structure of the surface film, in order to control the bulk properties of complex fluids.Read moreRead less
Polymer optical fibres with controlled molecular orientation for photonic applications. The objective of the proposed research is to boost the advantage of Australian scientists and engineers working in the field of photonics by investigating new physical principles and new ways of fabricating specialty plastic optical fibres. Such fibres can be used in optical devices, to improve transmission and processing of signals in data communications, for improving efficient operation of power industry, ....Polymer optical fibres with controlled molecular orientation for photonic applications. The objective of the proposed research is to boost the advantage of Australian scientists and engineers working in the field of photonics by investigating new physical principles and new ways of fabricating specialty plastic optical fibres. Such fibres can be used in optical devices, to improve transmission and processing of signals in data communications, for improving efficient operation of power industry, in biophotonics.
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Remodelling encapsulin nanocages to help enhance plant carbon fixation. Nature has evolved mechanisms in microbial systems to improve photosynthetic efficiency by saturating the enzyme Rubisco with carbon dioxide. These carbon concentrating mechanisms are genetically complex, precluding successful introduction into crops. Our simpler approach is to use encapsulins, a new source of robust bacterial pore-containing nanocages made from a single gene. This project will optimise the development of sy ....Remodelling encapsulin nanocages to help enhance plant carbon fixation. Nature has evolved mechanisms in microbial systems to improve photosynthetic efficiency by saturating the enzyme Rubisco with carbon dioxide. These carbon concentrating mechanisms are genetically complex, precluding successful introduction into crops. Our simpler approach is to use encapsulins, a new source of robust bacterial pore-containing nanocages made from a single gene. This project will optimise the development of synthetic encapsulin-Rubisco carbon-fixing nanoreactors and transform them into leaf chloroplasts to test their impact on plant photosynthesis and growth. Our genetically simpler solution will aid ongoing global efforts to deliver overdue step change improvements in agricultural productivity.Read moreRead less
Smart materials for atmospheric water management and water harvesting. Fresh water is a scarce resource in many parts of the globe but uncomfortably over-supplied in other regions. Dehumidifying machines, such as air conditioners, are extensively used in humid climates to enhance human comfort, but with great energy costs. Likewise, the production of potable water in remote dry regions is energy intensive. We propose novel hyper-absorbent desiccating polymers combined into sorption-powered engin ....Smart materials for atmospheric water management and water harvesting. Fresh water is a scarce resource in many parts of the globe but uncomfortably over-supplied in other regions. Dehumidifying machines, such as air conditioners, are extensively used in humid climates to enhance human comfort, but with great energy costs. Likewise, the production of potable water in remote dry regions is energy intensive. We propose novel hyper-absorbent desiccating polymers combined into sorption-powered engines inspired by nastic movements in plants to develop extremely efficient dehumidifiers and water harvesting machines. These polymer actuators can help address the auto-acceleration of climate change caused by the increasing use of air conditioners and provide cheap, clean water for remote communities.Read moreRead less