Radio-magnetic nanoparticles as bimodal positron emission tomography/magnetic resonance imaging contrast agents for dendritic cell tracking. Biomedical imaging is limited by a lack of commercial dual-mode contrast agents, which may be simultaneously used for magnetic resonance (MR) and positron emission tomography (PET) imaging. This project will develop a nanotechnology-based biocompatible dual-mode contrast agent for simultaneous PET and MR imaging, reducing associated side effects.
Discovery Early Career Researcher Award - Grant ID: DE180100294
Funder
Australian Research Council
Funding Amount
$368,446.00
Summary
Topochemical conversion of layers of graphene into diamond-like thin films. This project aims to experimentally convert layers of graphene into diamond-like thin films via novel chemical hydrogenation and fluorination approaches. Unconventional diamond-like thin films that possess remarkable physicochemical properties will be produced to trigger significant theoretical and technological interests in nano-carbon research. The project expects to impact the fundamental understanding of this new cla ....Topochemical conversion of layers of graphene into diamond-like thin films. This project aims to experimentally convert layers of graphene into diamond-like thin films via novel chemical hydrogenation and fluorination approaches. Unconventional diamond-like thin films that possess remarkable physicochemical properties will be produced to trigger significant theoretical and technological interests in nano-carbon research. The project expects to impact the fundamental understanding of this new class of graphene-derived materials whilst driving cutting-edge technological advances in electrochemical applications, membrane technologies and quantum computing.Read moreRead less
Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less
Advanced separators for lithium-sulphur batteries. This project aims to develop new membranes for use as separators in lithium-sulphur batteries. Currently diffusion of polysulphides within these batteries reduces battery power and lifetime. The new membranes are intended to block polysulphide diffusion over an extended lifetime, while transporting the other ions needed for the battery to function. The project is expected to generate new membrane materials and further knowledge about the design, ....Advanced separators for lithium-sulphur batteries. This project aims to develop new membranes for use as separators in lithium-sulphur batteries. Currently diffusion of polysulphides within these batteries reduces battery power and lifetime. The new membranes are intended to block polysulphide diffusion over an extended lifetime, while transporting the other ions needed for the battery to function. The project is expected to generate new membrane materials and further knowledge about the design, synthesis and larger-scale production of membranes for electrochemical applications. This project will provide significant benefits by producing potentially lighter, longer-lasting and cheaper batteries than existing lithium-ion technologies, with the potential to accelerate the adoption of electric cars.Read moreRead less
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
Engineering two dimensional polymers for membrane-based chemical separation. This project aims to develop novel two-dimensional polymers with precisely controlled pore-sizes for preparing membrane materials which can efficiently separate these gaseous chemicals at ambient temperatures. Key industrial chemical mixtures with similar size and boiling points are difficult to separate by conventional distillation methods. Currently, purification of olefins alone accounts for 0.3% of global energy use ....Engineering two dimensional polymers for membrane-based chemical separation. This project aims to develop novel two-dimensional polymers with precisely controlled pore-sizes for preparing membrane materials which can efficiently separate these gaseous chemicals at ambient temperatures. Key industrial chemical mixtures with similar size and boiling points are difficult to separate by conventional distillation methods. Currently, purification of olefins alone accounts for 0.3% of global energy use. The expected outcomes of the project will have a huge impact on industrial purification processing by providing a disruptive membrane technology, and will significantly reduce energy consumption and open up new routes for resources.Read moreRead less
Polymer nanodiscs. This project aims to produce disc-shaped polymer nanomaterials by utilising a new self-assembly concept based on oppositely charged polymers. This project expects to generate a modular technology that allows synthesis and control over the geometry and functionality of polymer nanoparticles. This level of control will permit a precise investigation of polymer nanodisc properties for nanomedicine applications. Expected outcomes of this project will be the fundamental understandi ....Polymer nanodiscs. This project aims to produce disc-shaped polymer nanomaterials by utilising a new self-assembly concept based on oppositely charged polymers. This project expects to generate a modular technology that allows synthesis and control over the geometry and functionality of polymer nanoparticles. This level of control will permit a precise investigation of polymer nanodisc properties for nanomedicine applications. Expected outcomes of this project will be the fundamental understanding of how nanoparticle geometry affects particle-cell interaction and how nanoscale polymer discs can be used to mimic biological nanoparticles in shape and function.Read moreRead less
Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly t ....Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly technology, new knowledge of cell-nanomaterial interactions and new design principles for nanoparticles with potential future applications in drug delivery, immunology and nanomedicine. This project should provide significant benefits to polymer, nanomaterial and pharmaceutical research and industry in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100007
Funder
Australian Research Council
Funding Amount
$386,500.00
Summary
A modular toolbox of novel polymer nanorods for better tissue penetration. This project aims to establish a suite of design parameters to provide new avenues for understanding and manipulating tissue infiltration by future therapeutic nanoparticles. The project expects to develop an innovative technology that allows independent control over nanoparticle geometry, functionality, and mechanical and surface properties. This level of control over the synthesis of polymer nanoparticles with distinct ....A modular toolbox of novel polymer nanorods for better tissue penetration. This project aims to establish a suite of design parameters to provide new avenues for understanding and manipulating tissue infiltration by future therapeutic nanoparticles. The project expects to develop an innovative technology that allows independent control over nanoparticle geometry, functionality, and mechanical and surface properties. This level of control over the synthesis of polymer nanoparticles with distinct physicochemical properties will enable precise adjustment and investigation of discrete particle properties. The project will reshape fundamental knowledge of nanoparticle design by demonstrating the centrality of particle shape, stiffness, and heterogeneity. The outcomes will significantly advance the science of polymer nanoparticle synthesis control, aiding the development of novel and more effective polymer nano-therapeutics.Read moreRead less
Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailor ....Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailored towards bioactive and biocompatible material to create a drug delivery platform for more efficient disease treatment. The outcome will be better understanding on how polymer platelets can be obtained and how they compare in their biological activity with spherical nanoparticles.Read moreRead less