Radio-magnetic nanoparticles as bimodal positron emission tomography/magnetic resonance imaging contrast agents for dendritic cell tracking. Biomedical imaging is limited by a lack of commercial dual-mode contrast agents, which may be simultaneously used for magnetic resonance (MR) and positron emission tomography (PET) imaging. This project will develop a nanotechnology-based biocompatible dual-mode contrast agent for simultaneous PET and MR imaging, reducing associated side effects.
Discovery Early Career Researcher Award - Grant ID: DE180100294
Funder
Australian Research Council
Funding Amount
$368,446.00
Summary
Topochemical conversion of layers of graphene into diamond-like thin films. This project aims to experimentally convert layers of graphene into diamond-like thin films via novel chemical hydrogenation and fluorination approaches. Unconventional diamond-like thin films that possess remarkable physicochemical properties will be produced to trigger significant theoretical and technological interests in nano-carbon research. The project expects to impact the fundamental understanding of this new cla ....Topochemical conversion of layers of graphene into diamond-like thin films. This project aims to experimentally convert layers of graphene into diamond-like thin films via novel chemical hydrogenation and fluorination approaches. Unconventional diamond-like thin films that possess remarkable physicochemical properties will be produced to trigger significant theoretical and technological interests in nano-carbon research. The project expects to impact the fundamental understanding of this new class of graphene-derived materials whilst driving cutting-edge technological advances in electrochemical applications, membrane technologies and quantum computing.Read moreRead less
Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100007
Funder
Australian Research Council
Funding Amount
$386,500.00
Summary
A modular toolbox of novel polymer nanorods for better tissue penetration. This project aims to establish a suite of design parameters to provide new avenues for understanding and manipulating tissue infiltration by future therapeutic nanoparticles. The project expects to develop an innovative technology that allows independent control over nanoparticle geometry, functionality, and mechanical and surface properties. This level of control over the synthesis of polymer nanoparticles with distinct ....A modular toolbox of novel polymer nanorods for better tissue penetration. This project aims to establish a suite of design parameters to provide new avenues for understanding and manipulating tissue infiltration by future therapeutic nanoparticles. The project expects to develop an innovative technology that allows independent control over nanoparticle geometry, functionality, and mechanical and surface properties. This level of control over the synthesis of polymer nanoparticles with distinct physicochemical properties will enable precise adjustment and investigation of discrete particle properties. The project will reshape fundamental knowledge of nanoparticle design by demonstrating the centrality of particle shape, stiffness, and heterogeneity. The outcomes will significantly advance the science of polymer nanoparticle synthesis control, aiding the development of novel and more effective polymer nano-therapeutics.Read moreRead less
Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailor ....Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailored towards bioactive and biocompatible material to create a drug delivery platform for more efficient disease treatment. The outcome will be better understanding on how polymer platelets can be obtained and how they compare in their biological activity with spherical nanoparticles.Read moreRead less
Highly ordered and tuneable mesostructured perfluorosulfonic acid polymers as novel proton exchange membranes for fuel cells. The purpose of the project is to develop an innovative perfluorofonic acid based proton exchange membranes (PEM) with ordered and tuneable mesopores and it is expected that PEM fuel cell power systems based on such new PEMs will have significant impact on the advancement of fuel cell technologies and the reduction in greenhouse gas emission.
Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. The ....Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. These materials are expected to provide benefits for Australian citizens in the energy and health sectors and contribute to the development of a robust Australian nanotechnology industry. The projects will also provide opportunities for the development of outstanding young scientists and will foster multidisciplinary collaborations.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100052
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling ....Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling molecule and genes to cells. The project aims to inform future optimal design criteria for bespoke nanoparticle delivery systems.Read moreRead less
Functional molecular nanomaterials. The design and construction of advanced nanomaterials is a key step in the push towards more efficient energy systems and smarter technologies. Through the strategic assembly of new classes of molecular nanomaterials, this project will lead to important fundamental advances in nanoscience and will underpin a range of new high-level technologies.
Nanoparticle inks for electronic applications employing nanostructured thin-films. The development of next-generation technologies requires careful engineering of materials at the nanoscale. Using nanoparticle inks, many of the engineering difficulties which exist at these length scales can be overcome, thus allowing for technologies such as thin-film solar cells to become cheaper and more efficient.