Fighting slime with free radicals - new surface coatings for biofilm remediation. Bacterial biofilms are a major problem in a number of environmental, industrial and medical applications. They cause significant risks to human health and present an enormous economic burden to society. This project aims to develop smart polymeric coatings that will discourage bacterial attachment and ensure greater long term control over biofilm growth. These coatings represent a breakthrough in the field and will ....Fighting slime with free radicals - new surface coatings for biofilm remediation. Bacterial biofilms are a major problem in a number of environmental, industrial and medical applications. They cause significant risks to human health and present an enormous economic burden to society. This project aims to develop smart polymeric coatings that will discourage bacterial attachment and ensure greater long term control over biofilm growth. These coatings represent a breakthrough in the field and will have a profound impact in many areas, including reducing infections related to medical implants and improving the efficiency of marine engineering systems.Read moreRead less
Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will ....Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will represent a breakthrough in the field and will have a profound impact by reducing infection rates associated with medical devices and improving airway clearance in cystic fibrosis patients.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100100
Funder
Australian Research Council
Funding Amount
$975,934.00
Summary
Multifunctional Platform for Chemical Manufacturing and Energy Materials. We aim to establish the first platform in Australia for the continuous production and in-situ characterisation of molecules and nanomaterials. This project expects to generate new knowledge in the area of functional materials using an interdisciplinary approach. The expected outcomes will be a unique analytical capability for rapid screening of synthetic and operational parameters, and unprecedented fundamental insight int ....Multifunctional Platform for Chemical Manufacturing and Energy Materials. We aim to establish the first platform in Australia for the continuous production and in-situ characterisation of molecules and nanomaterials. This project expects to generate new knowledge in the area of functional materials using an interdisciplinary approach. The expected outcomes will be a unique analytical capability for rapid screening of synthetic and operational parameters, and unprecedented fundamental insight into chemical reactions to inform the design and development of sustainable chemical processes. This proposal will provide significant benefits to cutting-edge research in catalysis, polymer engineering, separation science, CO2 capture and organic synthesis, to positively impact on the energy-manufacturing-environment nexus.Read moreRead less
On-demand visible light degradable dental materials. This project aims to break new ground in the field of advanced adhesives by pioneering a unique system that can be cleaved with a defined visible light trigger, enabling the removal of previously bonded material without mechanical force. This would allow two materials to be strongly bonded, including dental crowns, braces and implants. The project will advance on-demand degradable materials design, introducing an advanced class of responsive n ....On-demand visible light degradable dental materials. This project aims to break new ground in the field of advanced adhesives by pioneering a unique system that can be cleaved with a defined visible light trigger, enabling the removal of previously bonded material without mechanical force. This would allow two materials to be strongly bonded, including dental crowns, braces and implants. The project will advance on-demand degradable materials design, introducing an advanced class of responsive networks for applications where reversible bonding is critical. It will have flow on benefits in future dental material applications and also have applications where simple-to-remove, temporary adhesives are required.Read moreRead less
Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less
A new generation of photoresists for three- dimensional laser lithography. This project aims at a step-change in photoresist technology by introducing visible-light-induced photochemistry as the basis of next generation direct laser writing (DLW) technology. This willenable functional photoresists that allow precision coding of complex soft matter material properties on the three-dimensional nanoscale. The outcomes of the project will enable the mild fabrication of three-dimensional structures w ....A new generation of photoresists for three- dimensional laser lithography. This project aims at a step-change in photoresist technology by introducing visible-light-induced photochemistry as the basis of next generation direct laser writing (DLW) technology. This willenable functional photoresists that allow precision coding of complex soft matter material properties on the three-dimensional nanoscale. The outcomes of the project will enable the mild fabrication of three-dimensional structures with unique property control and resolution, benefitting diverse fields ranging from designer (stem) cell niches and lab-on-a-chip applications to photonic wire bonding.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100014
Funder
Australian Research Council
Funding Amount
$3,275,680.00
Summary
Light-Induced chemical modularity: a new frontier in macromolecular design. This project aims to develop powerful light-driven chemistries for the modular construction of advanced macromolecular materials. The expected outcome is a versatile, light-based precision macromolecular synthetic technology platform, enabling critical advances in soft matter material design and synthesis, ranging from selectivity control of chemical reactions and information-coded and biomimetic light-responsive macromo ....Light-Induced chemical modularity: a new frontier in macromolecular design. This project aims to develop powerful light-driven chemistries for the modular construction of advanced macromolecular materials. The expected outcome is a versatile, light-based precision macromolecular synthetic technology platform, enabling critical advances in soft matter material design and synthesis, ranging from selectivity control of chemical reactions and information-coded and biomimetic light-responsive macromolecules to advanced functional photoresists for 3D laser lithography as well as materials that self-report structural transformations by light or are reprogrammable in their properties by photonic fields. Harnessing the power of light as a precision tool for the construction of advanced macromolecular materials will provide technology outcomes for Australian manufacturing industries from electronics to health. This includes laser-driven 3D printing technology at the nano-level, light-adaptive smart reprogrammable coatings and materials, synthetic proteins responsive to light as well as tailor-made single cell niches.Read moreRead less
Mimicking the perivascular niche with boronolectin-based biomaterials. This project aims to address roadblocks in perivascular stem cell manufacturing by discovering novel mechanisms and materials that improve cell quality outcomes during extended culture. An innovative, interdisciplinary approach to biomaterials discovery, combining live cell-based screening of cell surface glycans, bio-inspired materials design and synthesis, and niche mimicry, will enable the discovery of cell surface glycan- ....Mimicking the perivascular niche with boronolectin-based biomaterials. This project aims to address roadblocks in perivascular stem cell manufacturing by discovering novel mechanisms and materials that improve cell quality outcomes during extended culture. An innovative, interdisciplinary approach to biomaterials discovery, combining live cell-based screening of cell surface glycans, bio-inspired materials design and synthesis, and niche mimicry, will enable the discovery of cell surface glycan-mediated interactions that support long-term expansion and potency maintenance, and synthetic biomaterials that can mimic them. Significant benefits for stem cell researchers, manufacturers and end users are expected from the project and the application of this scalable biomaterial platform.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less