Real-time imaging of crystal strengthening mechanisms in metals. The strength limit of a metal is marked by rapid motion of crystalline defects. The associated speeds can locally approach that of sound. To probe the associated mechanisms clearly requires both spatial and temporal resolution. We propose to create a new bulk x-ray technique with an unprecedented combination of temporal and spatial resolution. We plan to exploit the technique to mediate a step change in modelling strength based on ....Real-time imaging of crystal strengthening mechanisms in metals. The strength limit of a metal is marked by rapid motion of crystalline defects. The associated speeds can locally approach that of sound. To probe the associated mechanisms clearly requires both spatial and temporal resolution. We propose to create a new bulk x-ray technique with an unprecedented combination of temporal and spatial resolution. We plan to exploit the technique to mediate a step change in modelling strength based on twinning. The formation of crystalline twins is known to dictate the strength of the light metal magnesium. A fuller understanding of the effect of twinning on strength in this metal will provide much needed confidence to implement it more widely in energy saving applications.Read moreRead less
Visualising molecular level detail in single cells and intact tissues. The goal of this project is to deliver a new toolkit for imaging cells at an unprecedented resolution and level of chemical detail. We will expand the capabilities of two existing, but complementary, methods: optical fluorescence microscopy with responsive probes and X-ray fluorescence imaging. Expected outcomes include improved techniques and benchmarks for visualising bacterial and mammalian cells; development of new molecu ....Visualising molecular level detail in single cells and intact tissues. The goal of this project is to deliver a new toolkit for imaging cells at an unprecedented resolution and level of chemical detail. We will expand the capabilities of two existing, but complementary, methods: optical fluorescence microscopy with responsive probes and X-ray fluorescence imaging. Expected outcomes include improved techniques and benchmarks for visualising bacterial and mammalian cells; development of new molecules for elucidating cellular chemistry; better utilisation of valuable synchrotron resources; and greater understanding of the strengths and limitations of current microscopy workflows. Results should benefit the biotechnology sector, and may lead to improved medical, diagnostic, and bioremediation capacity.Read moreRead less
Radiation detectors to better understand ion interactions. This project aims to build a Heavy Ion Therapy Research and Treatment Centre in Australia. Understanding how ions interact with matter and their radiobiological effectiveness (RBE) is important. The project will introduce an Australian detector technology platform to research ion interaction physics and their RBE. It will develop radiation detectors for ion measurement with a wide energy range, including a practical RBE quality assurance ....Radiation detectors to better understand ion interactions. This project aims to build a Heavy Ion Therapy Research and Treatment Centre in Australia. Understanding how ions interact with matter and their radiobiological effectiveness (RBE) is important. The project will introduce an Australian detector technology platform to research ion interaction physics and their RBE. It will develop radiation detectors for ion measurement with a wide energy range, including a practical RBE quality assurance tool with submillimetre spatial resolution. The proposed Australian radiation detection technology is expected to improve understanding of the scientific mechanisms underpinning the radiobiological effectiveness of heavy ion radiation.Read moreRead less
Profiling tissue protein, elemental ions and nanoparticle distributions. This project aims to investigate protein-protein interactions that are crucial to homeostatic cell signalling and viability in a changing tissue environment. The central goal is to develop and validate protocols to combine cutting-edge tissue imaging modalities to map and characterise tissue distributions of native and modified proteins, elemental ions and pharmacological agents including nanoparticles and nanovehicles. The ....Profiling tissue protein, elemental ions and nanoparticle distributions. This project aims to investigate protein-protein interactions that are crucial to homeostatic cell signalling and viability in a changing tissue environment. The central goal is to develop and validate protocols to combine cutting-edge tissue imaging modalities to map and characterise tissue distributions of native and modified proteins, elemental ions and pharmacological agents including nanoparticles and nanovehicles. The aim is to use novel tissue scanning mass spectrometry techniques in conjunction with X-ray-based microprobe spectroscopy and advanced multi-parameter cytometry to identify spatial distributions of proteins, ions and drugs in tissues. This approach may provide new information about the maintenance of homeostatic control and the content, distribution and potential metabolism of drugs or nanoparticles within biological tissues.Read moreRead less
Carbon conundrum: Functional characterisation of organic matter-clay mineral interactions in relation to carbon sequestration. Carbon sequestration in soil has been recognised as one of the possible measures through which greenhouse gas emissions can be mitigated. The major processes involved in carbon sequestration in soil include chemical immobilisation of carbon with soil particles and physical protection in the pores of soil microaggregates. These two processes are mediated through the funct ....Carbon conundrum: Functional characterisation of organic matter-clay mineral interactions in relation to carbon sequestration. Carbon sequestration in soil has been recognised as one of the possible measures through which greenhouse gas emissions can be mitigated. The major processes involved in carbon sequestration in soil include chemical immobilisation of carbon with soil particles and physical protection in the pores of soil microaggregates. These two processes are mediated through the functional relationships of soil organic matter and clay mineral interactions in soils. This project investigates nanoscale organomineral association underlying microaggregate formation and stability, as well as the distribution and microbial decomposition of carbon within microaggregates using a suite of advanced spectroscopic, molecular and isotopic techniques.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100073
Funder
Australian Research Council
Funding Amount
$174,627.00
Summary
Australian Contribution to CERN Large Hadron Collider Experiment Upgrade. Australian contribution to CERN large hadron collider experiment upgrade: The discovery of the Higgs Boson with the ATLAS experiment at the CERN laboratory's large hadron collider, has been a highlight for Australian science. Scientists will build upon the foundation of the Higgs discovery to further probe the nature of matter at the finest scales and highest energies. Detailed measurements of the Higgs characteristics wil ....Australian Contribution to CERN Large Hadron Collider Experiment Upgrade. Australian contribution to CERN large hadron collider experiment upgrade: The discovery of the Higgs Boson with the ATLAS experiment at the CERN laboratory's large hadron collider, has been a highlight for Australian science. Scientists will build upon the foundation of the Higgs discovery to further probe the nature of matter at the finest scales and highest energies. Detailed measurements of the Higgs characteristics will determine if it is as predicted by the Standard Model or whether it admits a variation, signalling new physics. The upgrade in this project will provide for such detailed measurements. It will also allow sensitive probes of new physics, searching for new particles or unexpected interactions.Read moreRead less
Characterisation of the beneficial vs toxic forms of selenium in the diet. This project aims to examine how dietary selenium is converted into essential proteins and beneficial compounds that mitigate against a broad range of human diseases; or alternatively, into toxic molecules. Cutting-edge methodologies should resolve significant unknowns in selenium metabolism, to provide definitive dietary guidelines and to explore how selenium can treat and protect against disease. Expected outcomes from ....Characterisation of the beneficial vs toxic forms of selenium in the diet. This project aims to examine how dietary selenium is converted into essential proteins and beneficial compounds that mitigate against a broad range of human diseases; or alternatively, into toxic molecules. Cutting-edge methodologies should resolve significant unknowns in selenium metabolism, to provide definitive dietary guidelines and to explore how selenium can treat and protect against disease. Expected outcomes from this national and international collaboration include expert training for young biochemical researchers and refinements to novel analytical techniques. Results should benefit the food and agricultural sectors to provide tailored products locally and for export, as well as enhanced health opportunities for all Australians.Read moreRead less
Resonant tender X-ray scattering of organic semiconductors. This project aims to establish resonant tender X-ray scattering as a mature technique for unravelling the complex microstructure of organic semiconductor layers. By understanding and exploiting the resonant interaction between organic semiconductors and X-rays tuned to appropriate absorption edges, new information about the molecular packing of these materials will be obtained. The expected outcomes are new experimental methodologies an ....Resonant tender X-ray scattering of organic semiconductors. This project aims to establish resonant tender X-ray scattering as a mature technique for unravelling the complex microstructure of organic semiconductor layers. By understanding and exploiting the resonant interaction between organic semiconductors and X-rays tuned to appropriate absorption edges, new information about the molecular packing of these materials will be obtained. The expected outcomes are new experimental methodologies and analysis tools for determining the complex structure of technologically relevant materials. Benefits include understanding of the properties of solution-processed semiconductors enabling the design of high performance materials with applications in energy, electronics, lighting and health.Read moreRead less