Visualising molecular level detail in single cells and intact tissues. The goal of this project is to deliver a new toolkit for imaging cells at an unprecedented resolution and level of chemical detail. We will expand the capabilities of two existing, but complementary, methods: optical fluorescence microscopy with responsive probes and X-ray fluorescence imaging. Expected outcomes include improved techniques and benchmarks for visualising bacterial and mammalian cells; development of new molecu ....Visualising molecular level detail in single cells and intact tissues. The goal of this project is to deliver a new toolkit for imaging cells at an unprecedented resolution and level of chemical detail. We will expand the capabilities of two existing, but complementary, methods: optical fluorescence microscopy with responsive probes and X-ray fluorescence imaging. Expected outcomes include improved techniques and benchmarks for visualising bacterial and mammalian cells; development of new molecules for elucidating cellular chemistry; better utilisation of valuable synchrotron resources; and greater understanding of the strengths and limitations of current microscopy workflows. Results should benefit the biotechnology sector, and may lead to improved medical, diagnostic, and bioremediation capacity.Read moreRead less
Carbon conundrum: Functional characterisation of organic matter-clay mineral interactions in relation to carbon sequestration. Carbon sequestration in soil has been recognised as one of the possible measures through which greenhouse gas emissions can be mitigated. The major processes involved in carbon sequestration in soil include chemical immobilisation of carbon with soil particles and physical protection in the pores of soil microaggregates. These two processes are mediated through the funct ....Carbon conundrum: Functional characterisation of organic matter-clay mineral interactions in relation to carbon sequestration. Carbon sequestration in soil has been recognised as one of the possible measures through which greenhouse gas emissions can be mitigated. The major processes involved in carbon sequestration in soil include chemical immobilisation of carbon with soil particles and physical protection in the pores of soil microaggregates. These two processes are mediated through the functional relationships of soil organic matter and clay mineral interactions in soils. This project investigates nanoscale organomineral association underlying microaggregate formation and stability, as well as the distribution and microbial decomposition of carbon within microaggregates using a suite of advanced spectroscopic, molecular and isotopic techniques.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100073
Funder
Australian Research Council
Funding Amount
$174,627.00
Summary
Australian Contribution to CERN Large Hadron Collider Experiment Upgrade. Australian contribution to CERN large hadron collider experiment upgrade: The discovery of the Higgs Boson with the ATLAS experiment at the CERN laboratory's large hadron collider, has been a highlight for Australian science. Scientists will build upon the foundation of the Higgs discovery to further probe the nature of matter at the finest scales and highest energies. Detailed measurements of the Higgs characteristics wil ....Australian Contribution to CERN Large Hadron Collider Experiment Upgrade. Australian contribution to CERN large hadron collider experiment upgrade: The discovery of the Higgs Boson with the ATLAS experiment at the CERN laboratory's large hadron collider, has been a highlight for Australian science. Scientists will build upon the foundation of the Higgs discovery to further probe the nature of matter at the finest scales and highest energies. Detailed measurements of the Higgs characteristics will determine if it is as predicted by the Standard Model or whether it admits a variation, signalling new physics. The upgrade in this project will provide for such detailed measurements. It will also allow sensitive probes of new physics, searching for new particles or unexpected interactions.Read moreRead less
Characterisation of the beneficial vs toxic forms of selenium in the diet. This project aims to examine how dietary selenium is converted into essential proteins and beneficial compounds that mitigate against a broad range of human diseases; or alternatively, into toxic molecules. Cutting-edge methodologies should resolve significant unknowns in selenium metabolism, to provide definitive dietary guidelines and to explore how selenium can treat and protect against disease. Expected outcomes from ....Characterisation of the beneficial vs toxic forms of selenium in the diet. This project aims to examine how dietary selenium is converted into essential proteins and beneficial compounds that mitigate against a broad range of human diseases; or alternatively, into toxic molecules. Cutting-edge methodologies should resolve significant unknowns in selenium metabolism, to provide definitive dietary guidelines and to explore how selenium can treat and protect against disease. Expected outcomes from this national and international collaboration include expert training for young biochemical researchers and refinements to novel analytical techniques. Results should benefit the food and agricultural sectors to provide tailored products locally and for export, as well as enhanced health opportunities for all Australians.Read moreRead less
Special Research Initiatives - Grant ID: SR120200004
Funder
Australian Research Council
Funding Amount
$30,000,000.00
Summary
Australian Synchrotron Access Program. The Australian Synchrotron epitomises scientific research excellence in Australian and New Zealand. Its impact spans nearly every research sector. This proposal brings together over 30 Australian universities working together to ensure that world-class peer-reviewed science continues to be performed at the Australian Synchrotron.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100098
Funder
Australian Research Council
Funding Amount
$1,974,000.00
Summary
Enabling the Future of the Australian Collider Physics Program. The project aims to fund the continuation of Australia’s very successful experimental particle physics program to explore how the universe works at it's fundamental level. We interrogate subatomic matter at the energy frontier at CERN's Large Hadron Collider and the intensity frontier at Japan's SuperKEKB collider. The basic contributions required for Australian membership of these two key programs will enable scientists to continue ....Enabling the Future of the Australian Collider Physics Program. The project aims to fund the continuation of Australia’s very successful experimental particle physics program to explore how the universe works at it's fundamental level. We interrogate subatomic matter at the energy frontier at CERN's Large Hadron Collider and the intensity frontier at Japan's SuperKEKB collider. The basic contributions required for Australian membership of these two key programs will enable scientists to continue capitalising on decades of hard work and accumulated expertise, significant project outcomes and benefits include: access for Australia to advanced instruments and international research facilities; training of the next generation of researchers in detector construction and operation; and a rich science program.Read moreRead less
ARC Centre of Excellence for Dark Matter Particle Physics. The Centre of Excellence for Dark Matter Particle Physics will deliver breakthroughs in our understanding of the Universe through the pursuit of the discovery of dark matter particles which comprise 80% of the mass of the universe. It assembles for the first time a strong and diverse team of physicists from particle, nuclear, and quantum physics as well as particle astrophysics. It will deliver high-profile experiments using new cutting- ....ARC Centre of Excellence for Dark Matter Particle Physics. The Centre of Excellence for Dark Matter Particle Physics will deliver breakthroughs in our understanding of the Universe through the pursuit of the discovery of dark matter particles which comprise 80% of the mass of the universe. It assembles for the first time a strong and diverse team of physicists from particle, nuclear, and quantum physics as well as particle astrophysics. It will deliver high-profile experiments using new cutting-edge technologies. The Centre will exploit the unique geographical location of the first underground physics lab in the Southern Hemisphere. The ultra-sensitive detectors and ultra-low radiation techniques will translate into a broad range of industrial applications and train a new generation of scientists.Read moreRead less