Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the ....ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the core activities of the Network: Researcher Mobility, Workshops and Conferences, Postgraduate Education, and Knowledge Management Systems. The Network is expected to add significant value to pre-existing investments and raise the profile of Australian telecommunications research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346889
Funder
Australian Research Council
Funding Amount
$670,000.00
Summary
Optical fibre fabrication and characterisation facility for next-generation photonics research. Australia is a world leader in photonics, underpinning the future of information communications technologies. ICT research demands the next generation of optical fibres; requiring high precision, state-of-the-art fibre fabrication and characterization equipment for advanced research into new photonic materials and technologies. OFTC is the keystone supplier of application specific optical fibre to alm ....Optical fibre fabrication and characterisation facility for next-generation photonics research. Australia is a world leader in photonics, underpinning the future of information communications technologies. ICT research demands the next generation of optical fibres; requiring high precision, state-of-the-art fibre fabrication and characterization equipment for advanced research into new photonic materials and technologies. OFTC is the keystone supplier of application specific optical fibre to almost all photonics related research and developing industry in Australia. New equipment will enable OFTC to lead innovation and a high level of excellence in research in fundamental science, new technologies, new fibre including non-linear and photonic-bandgap, fibre devices, lasers and amplifiers, and support commercial development in Australia.Read moreRead less
Stability Analysis of Power System with Massive Power Electronic Devices. The decarbonization of Australia's power systems is to integrate massive renewable energy sources which are interfaced with many power electronic devices (PEDs). The fast and complex dynamics of PEDs have significantly changed the nature of the power system, which limits the applicability of existing tools and methods to assess its stability. The goal of this project is to gain a comprehensive insight into the stability of ....Stability Analysis of Power System with Massive Power Electronic Devices. The decarbonization of Australia's power systems is to integrate massive renewable energy sources which are interfaced with many power electronic devices (PEDs). The fast and complex dynamics of PEDs have significantly changed the nature of the power system, which limits the applicability of existing tools and methods to assess its stability. The goal of this project is to gain a comprehensive insight into the stability of a futuristic power system with high penetration of PEDs. The intended outcomes will be a model and data jointly driven methodology for high-efficient and real-time stability assessment. The methodology developed in this project will support Australia's transition to a stable, secure, and low-carbon power grid.Read moreRead less
Revealing the evolutionary and ecological dynamics of avian influenza virus. This project aims to understand how avian influenza virus (AIV) emerges, evolves and spreads in wild birds. AIV has the potential to devastate the poultry industry and cause human pandemics, but the factors that shape the genetic diversity of AIV in its wild bird reservoir are poorly understood. The project plans to combine genomic, ecological and phylogenetic approaches to reveal key aspects of AIV evolution, as well a ....Revealing the evolutionary and ecological dynamics of avian influenza virus. This project aims to understand how avian influenza virus (AIV) emerges, evolves and spreads in wild birds. AIV has the potential to devastate the poultry industry and cause human pandemics, but the factors that shape the genetic diversity of AIV in its wild bird reservoir are poorly understood. The project plans to combine genomic, ecological and phylogenetic approaches to reveal key aspects of AIV evolution, as well as the risk for future viral emergence. Using sampling sites in Australia and Antarctica, it plans to investigate AIV diversity, the evolutionary dynamics of AIV in wild birds and poultry, and the role played by environmental transmission in AIV ecology.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Australian literary publishing and its economies, 1965-1995. Australian literature is an essential aspect of Australian culture but its viability is currently under threat, both in the marketplace, and in tertiary and secondary education, where its coherence and relevance as a discipline has diminished over the past decade. Because it explores the different inputs that make for a vital literary culture, some of them intangible or discrete in their operation, the project will contribute to a bett ....Australian literary publishing and its economies, 1965-1995. Australian literature is an essential aspect of Australian culture but its viability is currently under threat, both in the marketplace, and in tertiary and secondary education, where its coherence and relevance as a discipline has diminished over the past decade. Because it explores the different inputs that make for a vital literary culture, some of them intangible or discrete in their operation, the project will contribute to a better understanding of how this culture works, and to a renewed confidence in its ability to sustain itself by commercial and non-commercial means.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347049
Funder
Australian Research Council
Funding Amount
$403,000.00
Summary
Building Australian Literary Knowledge Infrastructure. The primary goal of AustLit: the Australian Literature Gateway is to facilitate and encourage research in, and teaching of, the nation's creative and critical literature. AustLit's innovative world class resource discovery service utilises best practice techniques in information management and knowledge sharing. In 2003, AustLit will develop new technical services and important new content to meet the defined needs of a wide range of educati ....Building Australian Literary Knowledge Infrastructure. The primary goal of AustLit: the Australian Literature Gateway is to facilitate and encourage research in, and teaching of, the nation's creative and critical literature. AustLit's innovative world class resource discovery service utilises best practice techniques in information management and knowledge sharing. In 2003, AustLit will develop new technical services and important new content to meet the defined needs of a wide range of education and information consumers in the area. AustLit provides the foundation for a subject specific digital library that will retain and expand its usefulness into the future.Read moreRead less
Chemo-prevention of tropical canine parasitoses and vector-borne diseases. This project will determine the prevalence and diversity of established, emerging and novel canine vector-borne agents and endoparasites in a tropical setting by using conventional and next generation molecular diagnostic tools. It will fill an important gap by providing independently-verified evidence on how well canine anti-parasitic products marketed in Australia and Asia by Bayer Animal Health, perform in high-infecti ....Chemo-prevention of tropical canine parasitoses and vector-borne diseases. This project will determine the prevalence and diversity of established, emerging and novel canine vector-borne agents and endoparasites in a tropical setting by using conventional and next generation molecular diagnostic tools. It will fill an important gap by providing independently-verified evidence on how well canine anti-parasitic products marketed in Australia and Asia by Bayer Animal Health, perform in high-infection pressure settings, as a chemo-preventative for these disease agents. Tropical regions spanning northern Australia and Southern Asia are highly conducive to a plethora of canine vector-borne and parasitic pathogens that cause significant morbidity and mortality in dogs. Many of these agents also pose a risk to public health. The outcomes will be directly translated to best-practice guidelines for the advancement of companion animal (and indirectly human) health and welfare.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775729
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Improved understanding of nanoscale materials - structure, composition, crystallography and defects revealed by electron imaging and analysis at high spatial resolution. Modern materials scientists and engineers are driven by world-wide competition to develop new technology and manufactured devices. The trend has for some time been towards miniaturisation and one of the main challenges lies in effectively characterising nanostructures that are produced as a key step in research and development o ....Improved understanding of nanoscale materials - structure, composition, crystallography and defects revealed by electron imaging and analysis at high spatial resolution. Modern materials scientists and engineers are driven by world-wide competition to develop new technology and manufactured devices. The trend has for some time been towards miniaturisation and one of the main challenges lies in effectively characterising nanostructures that are produced as a key step in research and development of advanced materials. The proposed electron microscope and detectors will provide a state-of-the-art analytical facility to support the cross-disciplinary materials science and nanotechnology research at the Australian National University. It will also provide an important training facility for students and early-career researchers and will be available to investigators from other Australian institutions.Read moreRead less