Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the ....ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the core activities of the Network: Researcher Mobility, Workshops and Conferences, Postgraduate Education, and Knowledge Management Systems. The Network is expected to add significant value to pre-existing investments and raise the profile of Australian telecommunications research.Read moreRead less
Stability Analysis of Power System with Massive Power Electronic Devices. The decarbonization of Australia's power systems is to integrate massive renewable energy sources which are interfaced with many power electronic devices (PEDs). The fast and complex dynamics of PEDs have significantly changed the nature of the power system, which limits the applicability of existing tools and methods to assess its stability. The goal of this project is to gain a comprehensive insight into the stability of ....Stability Analysis of Power System with Massive Power Electronic Devices. The decarbonization of Australia's power systems is to integrate massive renewable energy sources which are interfaced with many power electronic devices (PEDs). The fast and complex dynamics of PEDs have significantly changed the nature of the power system, which limits the applicability of existing tools and methods to assess its stability. The goal of this project is to gain a comprehensive insight into the stability of a futuristic power system with high penetration of PEDs. The intended outcomes will be a model and data jointly driven methodology for high-efficient and real-time stability assessment. The methodology developed in this project will support Australia's transition to a stable, secure, and low-carbon power grid.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347049
Funder
Australian Research Council
Funding Amount
$403,000.00
Summary
Building Australian Literary Knowledge Infrastructure. The primary goal of AustLit: the Australian Literature Gateway is to facilitate and encourage research in, and teaching of, the nation's creative and critical literature. AustLit's innovative world class resource discovery service utilises best practice techniques in information management and knowledge sharing. In 2003, AustLit will develop new technical services and important new content to meet the defined needs of a wide range of educati ....Building Australian Literary Knowledge Infrastructure. The primary goal of AustLit: the Australian Literature Gateway is to facilitate and encourage research in, and teaching of, the nation's creative and critical literature. AustLit's innovative world class resource discovery service utilises best practice techniques in information management and knowledge sharing. In 2003, AustLit will develop new technical services and important new content to meet the defined needs of a wide range of education and information consumers in the area. AustLit provides the foundation for a subject specific digital library that will retain and expand its usefulness into the future.Read moreRead less
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100012
Funder
Australian Research Council
Funding Amount
$4,939,486.00
Summary
ARC Training Centre for Advanced Building Systems Against Airborne Infection Transmission. The aim of the Centre is to engineer building systems whose elements work together to reduce airborne infection transmission by improving indoor air quality while maintaining comfort and efficiency. The significance is in establishing clean indoor air as the norm, with Australian industry being the forerunner in this process. The outcomes include new intelligent building systems, improved building technolo ....ARC Training Centre for Advanced Building Systems Against Airborne Infection Transmission. The aim of the Centre is to engineer building systems whose elements work together to reduce airborne infection transmission by improving indoor air quality while maintaining comfort and efficiency. The significance is in establishing clean indoor air as the norm, with Australian industry being the forerunner in this process. The outcomes include new intelligent building systems, improved building technologies, quantitative methods for building control, evidence for policymaking and recommendations for operational guidelines. Wide-ranging benefits include reducing the health and economic burden of inadequate indoor air and increasing the competitiveness of Australian industry in the face of increasing demand for next-level building systems.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100021
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Energy Technologies for Future Grids. The proposed Future Grids Training Centre will advance Australia’s transition to a clean energy future. It will address the complex and challenging issues currently limiting the growth of renewable energy through innovations that facilitate widespread integration of these resources into electricity grids while maintaining grid stability. The Centre will deliver the next generation of industry leaders and specialists in future grid tech ....ARC Training Centre in Energy Technologies for Future Grids. The proposed Future Grids Training Centre will advance Australia’s transition to a clean energy future. It will address the complex and challenging issues currently limiting the growth of renewable energy through innovations that facilitate widespread integration of these resources into electricity grids while maintaining grid stability. The Centre will deliver the next generation of industry leaders and specialists in future grid technologies for renewable energy generation, transmission and distribution, supported by renewable hydrogen energy storage and market driven customer responsiveness enabled by new information and communications technologies, to provide a more sustainable, reliable, secure and affordable electricity system.Read moreRead less
Revolutionising real-time genomic epidemiology in urban wastewater systems. This project aims to develop a real-time and high-resolution genomic tool to monitor and track pathogens in urban wastewater systems based on the portable third-generation sequencing platform. Pathogens sicken hundreds of millions of people, cost the global economy tens of billions of dollars annually, and are one of the leading causes of death worldwide. The current epidemiology approach, and data, are retrospective and ....Revolutionising real-time genomic epidemiology in urban wastewater systems. This project aims to develop a real-time and high-resolution genomic tool to monitor and track pathogens in urban wastewater systems based on the portable third-generation sequencing platform. Pathogens sicken hundreds of millions of people, cost the global economy tens of billions of dollars annually, and are one of the leading causes of death worldwide. The current epidemiology approach, and data, are retrospective and thus insufficient for timely intervention. Integrated with wastewater analysis for pharmaceuticals targeting pathogens, the sewer-based epidemiology approach of this project will greatly enhance public health by achieving early detection and informed control of infectious diseases.Read moreRead less