Prospective Longitudinal Study - Symptom Clusters & Their Effects - Physical & Psychogical Functioning Patients Metastat
Funder
National Health and Medical Research Council
Funding Amount
$149,599.00
Summary
People with advanced cancer often experience several concurrent debilitating symptoms, yet most symptom research focuses on the study of individual symptoms. This study aims to gain a better understanding of the patterns and effects of specific groups of symptoms across the trajectory of a patient's illness following diagnosis of advanced cancer. Such knowledge is critical to the development of more focused symptom assessment processes and more appropriately targeted interventions.
A Multi-site Randomised Controlled Trial Comparing The Severity Of Constipation Symptoms Experienced By Palliative Care Patients Receiving Usual Care Compared To Those Diagnosed And Managed According To The Underlying Pathophysiology.
Funder
National Health and Medical Research Council
Funding Amount
$498,795.00
Summary
This research aims to consider whether the problems of constipation in palliative care are less severe when the physical changes that underlie the problem are explored.
Mechanisms Of Ataxia In Spinocerebellar Ataxia Type 1 Transgenic Mice
Funder
National Health and Medical Research Council
Funding Amount
$361,158.00
Summary
Degeneration of the coordination part of the brain (cerebellum) causes ATAXIA. There are many types, but few can be cured. The majority, affecting ~ 3,000 Australians, are progressive, and can only be helped by physical therapies. We are searching for a drug to improve the SYMPTOMS of ataxia, by analysing the chemical transmitters in the cerebellum in genetically ataxic mice. If we find an imbalance, we will trial appropriate drugs to try to correct this and lessen ataxia.
Australian Centre For Cannabinoid Clinical And Research Excellence (ACRE): Quality And Safety In The Implementation Of Medicinal Cannabis Use In The Community
Funder
National Health and Medical Research Council
Funding Amount
$2,498,471.00
Summary
Australia has a world-first opportunity to develop rigorous medical cannabis research based on quality clinical and environmental science that tests and selects cannabis constituents affecting health and sickness. It will be able to design and coordinate dose and formulation-finding studies to assess safety and efficacy of different cannabinoids. This information will enable registration of products for health that have been thoroughly researched and tested to levels acceptable for public use.
A Sequential Multiple Assignment Randomised Trial (SMART) Of Nursing Interventions To Reduce Pain Associated With Chemotherapy Induced Peripheral Neuropathy
Funder
National Health and Medical Research Council
Funding Amount
$713,418.00
Summary
Modern chemotherapy treatments can result in damage to the peripheral nerves, resulting in a condition called peripheral neuropathy. This condition is characterised by a range of sensory and functional changes that can cause pain and reduced ability to perform daily activities. This project will test various non-pharmacological pain management measures to determine if they are effective in improving the quality of life of patients who experience this problem.
Strengthening Community Based Paliative Care Services: Towards A Better Understanding Of Medical Aspects Of Caring For C
Funder
National Health and Medical Research Council
Funding Amount
$68,892.00
Summary
Caring for children [and their families] in the palliative phase of an illness offers unique challenges. Community based palliative care programs provide a predominantly adult focused service, their experience with children being limited by smaller numbers. This study aims to better characterize the medical aspects of caring for terminally ill children in Australia, thru the use of a parental survey in a large representative cohort at the Royal Children's Hospital, Melbourne (RCH). The focus wil ....Caring for children [and their families] in the palliative phase of an illness offers unique challenges. Community based palliative care programs provide a predominantly adult focused service, their experience with children being limited by smaller numbers. This study aims to better characterize the medical aspects of caring for terminally ill children in Australia, thru the use of a parental survey in a large representative cohort at the Royal Children's Hospital, Melbourne (RCH). The focus will be to identify issues relating to symptom assessment and management, family and caregiver support and psychosocial-bereavement support. The knowledge gained will be used to redesign-strengthen links between paediatric hospitals and community based palliative care programs.Read moreRead less
Development And Evaluation Of A Tailored Fatigue Self-management Behavioural Intervention For Patients With Advanced Cancer
Funder
National Health and Medical Research Council
Funding Amount
$157,836.00
Summary
Fatigue (tiredness and exhaustion) is one of the most distressing symptoms experienced by 74% of patients with advanced cancer. This research program aims to develop a sustainable intervention for enabling patients to use self-management strategies, thereby reducing the severity and impact of fatigue.
Systematic Expansion Of The Clinical Evidence Base In Opioid Prescribing For Refractory Dyspnoea At The End Of Life
Funder
National Health and Medical Research Council
Funding Amount
$414,535.00
Summary
Morphine can relieve breathlessness in the palliative setting. But many important questions remain. What is the best dose, should the dose change over time, do different medications provide the same relief, and how common is dyspnoea in the general population? This three part project will extend our knowledge to answer these questions. Population data will provide critical background to plan best care for future palliative patients distressed by breathlessness.
Prospective Study Of Medical Emergency Team Calls To Define Issues Of End Of Life Decision Making
Funder
National Health and Medical Research Council
Funding Amount
$48,700.00
Summary
A Medical Emergency Team (MET) is a specialised team of doctors and nurses from the Intensive Care Unit who urgently come to patients on the general wards whose medical condition is very unstable. They have to make crucial decisions about their treatment in a very short time. The previous research in this area has been focussed on improving medical outcomes, however it is also apparent that the patients having MET calls are often seriously ill with life limiting illnesses. This study aims to exp ....A Medical Emergency Team (MET) is a specialised team of doctors and nurses from the Intensive Care Unit who urgently come to patients on the general wards whose medical condition is very unstable. They have to make crucial decisions about their treatment in a very short time. The previous research in this area has been focussed on improving medical outcomes, however it is also apparent that the patients having MET calls are often seriously ill with life limiting illnesses. This study aims to explore the broader aspects of care at this time, which are of paramount importance to patients and their families, such as various aspects of communication, particularly focusing on changing goals of care; and also the symptoms that may be causing significant distress for the patient. This project will provide information that will assist development of interventions that will both aim to improve quality of life and also communication in the setting of medical emergencies in patients with life limiting illness.Read moreRead less
Cellular Modelling Of Attention Deficit Hyperactivity Disorder (ADHD) Risk Genes
Funder
National Health and Medical Research Council
Funding Amount
$753,746.00
Summary
Attention deficit hyperactivity disorder is a prevalent behavioural disorder affecting 7.4% of Australian children and adolescents. It has a strong genetic component with high heritability estimates (75–90%) comparable to other serious mental illness such as autism and schizophrenia. Identification and functional characterization of the genetic causes of this disorder will enhance our knowledge of its neurobiology and revolutionise the drug treatment of the disorder.