The Risks And Benefits Of Contemporary Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$493,530.00
Summary
The number of hip replacements undertaken in Australia is steadily increasing. The most common complications of hip replacements are dislocation and loosening due to bone loss around the implant, requiring complex and expensive revision surgery. This study will investigate the incidence of dislocation and, using a new diagnostic imaging technique, the incidence and amount of bone loss around a relatively new prosthetic material, the outcomes of which are not known despite its increasing use.
Attachment of Growth Factors to Pure, Plasma Modified and Coated Titanium Substrates. Titanium and its alloys are routinely used as medical and dental implants. Despite coating with hydroxyapatite, a material well known to improve implant fixation, many such implants fail because of lack of strong integration with bone. This proposal aims at achieving long-term stability of titanium implants through their surface modification and subsequent attachment of growth factors. The use of latter has alr ....Attachment of Growth Factors to Pure, Plasma Modified and Coated Titanium Substrates. Titanium and its alloys are routinely used as medical and dental implants. Despite coating with hydroxyapatite, a material well known to improve implant fixation, many such implants fail because of lack of strong integration with bone. This proposal aims at achieving long-term stability of titanium implants through their surface modification and subsequent attachment of growth factors. The use of latter has already been shown to help bone-implant integration. Successful project implementation will provide titanium implant surfaces that will help achieve speedier and improved implant fixation with long-term stability. Knowledge, expertise and techniques developed will help the industry partner expanding its research base and business and generating wealth in Australia. Training of world-class research students in the emerging field of biotechnology will be another major outcome.Read moreRead less
Development of a novel biodegradable ophthalmic biomaterial based on porous silicon. Within this interdisciplinary project, we will combine our diverse expertise towards the development of frontier technologies for control of stem cell behaviour on biodegradable scaffold materials. We will develop a novel ophthalmic bioimplant from porous silicon using topographical and chemical aspects of surface modification as well as immobilisation and/or incorporation of bioactive species such as growth fac ....Development of a novel biodegradable ophthalmic biomaterial based on porous silicon. Within this interdisciplinary project, we will combine our diverse expertise towards the development of frontier technologies for control of stem cell behaviour on biodegradable scaffold materials. We will develop a novel ophthalmic bioimplant from porous silicon using topographical and chemical aspects of surface modification as well as immobilisation and/or incorporation of bioactive species such as growth factors, to permit the growth and differentiation of mammalian stem cells. This project will result in biomaterials for the treatment of blinding diseases of the eye. Implanted into the limbus, bioimplants may ameliorate some common corneal diseases.Read moreRead less
Covalent Immobilisation of Growth Factors on Plasma Modified Titanium for Achieving Enhanced Bone Growth and Bonding in Implant Prosthetics. This project is aimed at improving the fixation of titanium implants by combining the surface technologies expertise of University of South Australia and Flinders University with TGR BioSciences's growth factors expertise. Plasma modified and hydroxyapatite-coated implant surfaces will be used for covalent immobilisation of growth factors via tethers with ....Covalent Immobilisation of Growth Factors on Plasma Modified Titanium for Achieving Enhanced Bone Growth and Bonding in Implant Prosthetics. This project is aimed at improving the fixation of titanium implants by combining the surface technologies expertise of University of South Australia and Flinders University with TGR BioSciences's growth factors expertise. Plasma modified and hydroxyapatite-coated implant surfaces will be used for covalent immobilisation of growth factors via tethers with tailored wettability and flexibility. This innovative strategy is expected to yield high retention of growth factor bioactivity and increased bone-implant integration for long-term implant stability. Knowledge, expertise and techniques developed will help TGR BioSciences expanding its research base and business. Training of students in the emerging field of nano-biotechnology will be another major outcome.Read moreRead less
Radiostereometric Analysis Of The Effect Of A Large Articulation On Prosthetic Wear And Migration After Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$192,186.00
Summary
At total hip replacement, there has been a recent trend to use prostheses with a larger ball and liner in the socket. This may decrease the risk of post-operative dislocation, but may also increase the amount of wear, leading to bone loss and loosening of prostheses, which may then require replacement. This project will use a special type of x-ray to determine whether wear and movement of these new prostheses is clinically acceptable, so that they can be used with confidence in patients.
Tracing Past and Present Pollution Sources in the River Torrens, South Australia. The Torrens River is the principal water supply to 500,000 South Australians. Since early in European settlement it has suffered the impacts of eutrophication and high rates of sedimentation. The Catchment Management Board is seeking to prioritise rehabilitation resources to maximise water quality improvements. This will be informed by the revelation of the principal sources of sediment and nutrients over time.
Innovative Approach to the Optimal Management of Water Resources and Application to the Upper South East Region of South Australia. This project will increase Australia's capacity to manage water resources in an integrated and sustainable manner. The outcomes of this project will also provide significant economic, social and environmental benefits to the Upper South East region of South Australia, as well as the broader Australian community. The project is expected to result in a significant red ....Innovative Approach to the Optimal Management of Water Resources and Application to the Upper South East Region of South Australia. This project will increase Australia's capacity to manage water resources in an integrated and sustainable manner. The outcomes of this project will also provide significant economic, social and environmental benefits to the Upper South East region of South Australia, as well as the broader Australian community. The project is expected to result in a significant reduction in the economic and social costs associated with dryland salinity and flooding whilst simultaneously increasing the environmental benefits associated with the maintenance and rehabilitation of the ecological value of the some of the region's approximately 200 wetlands.Read moreRead less
Innovative approaches to managing and understanding taste and odour in drinking water systems. Taste and odour (T/O) problems resulting from Cyanobacteria can change consumers' perception of product safety, resulting in many complaints, soaring management and treatment costs, and large financial losses, yet little is known about how they arise.
This project will provide the Australian Water Industry with cost-effective, sensitive, specific, rapid and practical tools for managing and understandi ....Innovative approaches to managing and understanding taste and odour in drinking water systems. Taste and odour (T/O) problems resulting from Cyanobacteria can change consumers' perception of product safety, resulting in many complaints, soaring management and treatment costs, and large financial losses, yet little is known about how they arise.
This project will provide the Australian Water Industry with cost-effective, sensitive, specific, rapid and practical tools for managing and understanding T/O episodes, and will also benefit the aquaculture and food sectors, and the research community. An improved ability to manage geosmin in drinking water, will also have positive repercussions on the Australian environment, by eliminating the need to use environmentally controversial control methods such as copper sulphate dosing.
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Examining the effectiveness of co-creation practices on health outcomes. This projects aims to examine how patients interact collaboratively with multiple stakeholders in a health system (co-creation). Governments and health-care providers continually seek new ways to be more efficient and to create more effective health service outcomes. This research aims to identify why co-creation will be important in the formulation of future health policy. The project plans to assess patient-centred practi ....Examining the effectiveness of co-creation practices on health outcomes. This projects aims to examine how patients interact collaboratively with multiple stakeholders in a health system (co-creation). Governments and health-care providers continually seek new ways to be more efficient and to create more effective health service outcomes. This research aims to identify why co-creation will be important in the formulation of future health policy. The project plans to assess patient-centred practices using qualitative and quantitative health outcome measures and to model the patient’s end-to-end journey by developing new metrics. The intended outcomes are practical guidelines to help health professionals focus on the most effective co-creation activities and interactions. The research aims to determine how co-creation practices shape a service ecosystem by examining the effectiveness of a patient-centred approach on health care service outcomes. Findings will improve the implementation of health care practices.Read moreRead less
Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribut ....Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribution, and delivery of products (smart information use). Improvement in the operational efficiency and performance of the supply chain will increase national wealth while minimising environmental impacts on the environment, for example, through the better utilisation of heavy freight carriers.Read moreRead less