CROSSFIRE: Combined Randomised And Observational Study Of Surgery For Fractures In The Distal Radius In The Elderly
Funder
National Health and Medical Research Council
Funding Amount
$551,077.00
Summary
Fractures (breaks) near the wrist are the most common fractures treated. Treatment previously consisted of straightening and plaster casting in the emergency department, but standard treatment now includes admission to hospital and surgery to apply a plate and screws to the bone. The best evidence we have (which is limited) is that surgical plating does not provide important benefits over plastering. We aim to perform a multicentre trial comparing plating to plaster for these common fractures.
Delayed Loss Of Acoustic Hearing After Cochlear Implantation: Mechanisms And Clinical Identification With New Cochlear Implant Technology
Funder
National Health and Medical Research Council
Funding Amount
$1,040,157.00
Summary
Natural hearing can be combined with a cochlear implant to improve sound quality and speech understanding. However, natural hearing frequently deteriorates weeks to months after cochlear implantation. This seems to occur when cochlear fluid buildup (hydrops) or fibrosis within the inner ear disrupts cochlear mechanics. We plan to monitor these processes in patients by recording directly from the cochlear implant, and conduct laboratory experiments to find therapies to alleviate their effects.
Randomised Controlled Trial Of Surgical Skin Preparation For Prevention Of Superficial Wound Complications In Prosthetic Hip And Knee Replacement Surgery
Funder
National Health and Medical Research Council
Funding Amount
$403,128.00
Summary
The demand for prosthetic joint replacement surgery will double over the next decade. Complications involving the surgical wound are a devastating complication of this surgery. This randomised controlled trial aims to investigate whether skin cleansing prior to surgical incision with alcoholic iodine reduces the number of patients with superficial wound complications when compared to alcoholic chlorhexidine. The study will be performed in patients undergoing orthopaedic joint replacement surgery ....The demand for prosthetic joint replacement surgery will double over the next decade. Complications involving the surgical wound are a devastating complication of this surgery. This randomised controlled trial aims to investigate whether skin cleansing prior to surgical incision with alcoholic iodine reduces the number of patients with superficial wound complications when compared to alcoholic chlorhexidine. The study will be performed in patients undergoing orthopaedic joint replacement surgery: a high volume, high cost surgery.Read moreRead less
The Arthroplasty Surgical Antibiotic Prophylaxis (ASAP) Study
Funder
National Health and Medical Research Council
Funding Amount
$3,509,985.00
Summary
The demand for total joint replacement surgery will double over the next decade. Infection involving the surgical wound is a devastating complication of this surgery. Half of all infections are due to methicillin resistant Staphylococcus (such as MRSA) and Enterococcus. This multicentre randomised controlled trial aims to investigate whether the addition of vancomycin at the time of surgery reduces the incidence of surgical wound infections; is safe and is cost-effective.
‘Granny was never the same after her operation’ is a strong public perception. These reports of persistent memory and concentration loss following surgery are now supported by a body of scientific research recording an incidence of ‘postoperative cognitive decline’ (POCD) as high as 75% in cardiac surgery patients. At present the cause is unknown but recently anaesthesia has been implicated. Our research team will investigate these claims.
Surgery For The Treatment Of Otitis Media In Indigenous Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$1,870,120.00
Summary
Ear infection (otitis media) is a major problem amongst children living in remote Australian communities. Medical treatment often fails, and ear nose and throat surgeons are called upon to provide surgical care. This clinical trial will provide surgeons with evidence so that they can recommend the best possible operation for children living in desert and tropical regions, most of whom are indigenous, to improve hearing and reduce the prevalence of ear infection and discharging ears.
Identifying And Implementing Standardised Outcomes In Kidney Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$274,076.00
Summary
The inconsistencies and lack of patient involvement in outcome selection for research can undermine shared decision-making and patient-centred care. Over three years, this global project will bring together patients,family members, healthcare providers, policy makers and industry to identify core outcomes in kidney transplantation. Implementation of the core outcome set will ensure that outcomes report in research are relevant, meaningful and important to patients with a kidney transplant.
REDucing Delays In Aneurysmal Subarachnoid Haemorrhage: The REDDISH Study
Funder
National Health and Medical Research Council
Funding Amount
$436,022.00
Summary
Aneurysmal subarachnoid haemorrhage (aSAH) is a rare form of stroke that kills at least 30% of sufferers within 1 month. Outcome can be improved through quickly receiving medical care but many people do not and this likely contributes to the poor outcomes. The REDucing Delays In Subarachnoid Haemorrhage (REDDISH) study will look at cases of aSAH across Tasmanian and Victoria so that we can understand the factors that contribute to delays in treatment and ultimately improve outcomes.
Outcomes After Serious Injury: What Is The Recovery Trajectory And How Do The Priorities For Treatment And Disability Services Change Over Time?
Funder
National Health and Medical Research Council
Funding Amount
$766,630.00
Summary
Traumatic injury is a significant contributor to global disease burden, with serious injury commonly resulting in disability and profound costs to the individual, family and society. This population-based project will describe the long term consequences of injury and recovery experiences of more than 2500 seriously injured patients. This longitudinal study will use quantitative and qualitative data to provide a comprehensive overview of patient outcomes and experiences in the first 5-years after ....Traumatic injury is a significant contributor to global disease burden, with serious injury commonly resulting in disability and profound costs to the individual, family and society. This population-based project will describe the long term consequences of injury and recovery experiences of more than 2500 seriously injured patients. This longitudinal study will use quantitative and qualitative data to provide a comprehensive overview of patient outcomes and experiences in the first 5-years after injury.Read moreRead less
IV Iron For Treatment Of Anaemia Before Cardiac Surgery (ITACS Trial)
Funder
National Health and Medical Research Council
Funding Amount
$2,285,290.00
Summary
Our aim is to evaluate intravenous iron to treat anaemia in 1000 patients waiting for their cardiac surgery. This could reduce the risks of the operation and enable patients to recover faster and can go home earlier.