Intelligent Freeform Bio-fabrication for Customised Anatomical Structures for Reconstructive Surgery. This project contributes towards the ARC priority goal on advanced materials and frontier technologies by developing an intelligent freeform biofabrication facility to produce accurate anatomical biocompatible replica structures and implants for reconstructive surgery. The products, produced from patient's CT or MRI scan data, will contribute to complex surgical procedure planning and patient ed ....Intelligent Freeform Bio-fabrication for Customised Anatomical Structures for Reconstructive Surgery. This project contributes towards the ARC priority goal on advanced materials and frontier technologies by developing an intelligent freeform biofabrication facility to produce accurate anatomical biocompatible replica structures and implants for reconstructive surgery. The products, produced from patient's CT or MRI scan data, will contribute to complex surgical procedure planning and patient education. The proposed facility will be based on multifunctional freeform fabrication process supported by intelligent software tools and database of biocompatible materials. The prospective outcomes are likely to have an excellent commercial and patenting potential that may help Australia become a leader in biomanufacturing technology.Read moreRead less
Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. ....Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. The development of technological innovations based on fabricated nanomaterials, will also enhance capacity in frontier technology such as nanotechnology, and build Australia’s strength in using new biosensing technologies.Read moreRead less
Fabrication and Application of Ion-Sensors Based on the Voltammetry of Nanocrystals Adhered to Electrode Surfaces. A significant need exists for the low cost determination of cations and anions in biologically (blood, urine), industrially (process streams) and environmentally (rivers, lakes) important fluids. In this project, skills in sensor design, scientific instrumentation, materials science, electrochemistry and analytical science provided by a consortium of scientists at Monash University ....Fabrication and Application of Ion-Sensors Based on the Voltammetry of Nanocrystals Adhered to Electrode Surfaces. A significant need exists for the low cost determination of cations and anions in biologically (blood, urine), industrially (process streams) and environmentally (rivers, lakes) important fluids. In this project, skills in sensor design, scientific instrumentation, materials science, electrochemistry and analytical science provided by a consortium of scientists at Monash University, the Victorian Institute for Chemical Sciences, Oxford Biosensors and Oxford University will be integrated to fabricate and develop applications of commercially viable ion-sensing systems. The principles to be utilised are based on novel forms of voltammetry of nanocrystals adhered to electrode surfaces.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560685
Funder
Australian Research Council
Funding Amount
$451,000.00
Summary
Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. Th ....Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. The bioelectrochemical imaging facility will be unique in Australia and establish an important cross-disciplinary approach within the international community.Read moreRead less
Solving the problem of detecting small molecules in complex samples: A Label-Free Electrochemical Immuno-biosensor for drugs and pesticides. Biosensors are portable analytical devices which can be used by the general public without specialist training. The proposed research will develop a biosensor for the detection of small molecules such as pesticides, poisons and drugs; a class of analytes where there is currently no viable biosensor technology. The simple to use device will benefit the Aus ....Solving the problem of detecting small molecules in complex samples: A Label-Free Electrochemical Immuno-biosensor for drugs and pesticides. Biosensors are portable analytical devices which can be used by the general public without specialist training. The proposed research will develop a biosensor for the detection of small molecules such as pesticides, poisons and drugs; a class of analytes where there is currently no viable biosensor technology. The simple to use device will benefit the Australian community by providing technology which will allow rapid and inexpensive monitoring of water as well as biomedical diagnosis. The research will also benefit Australia via providing the training of scientists to establish the new generation of Australia's bionanotechnology industry. Read moreRead less
The Application of Chemical Force Microscopy for Monitoring DNA Hybridization: A New Sensing Concept Capable of Detecting Single Molecules. This proposal outlines a method of monitoring DNA sequences with such high sensitivity that a single molecule may be detected. Such sensitivity is achieved using an atomic force microscope (AFM) to measure surface forces. Modifying an AFM tip with a single strand of DNA allows the complementary strand (the target) to be recognized via hybridization to form ....The Application of Chemical Force Microscopy for Monitoring DNA Hybridization: A New Sensing Concept Capable of Detecting Single Molecules. This proposal outlines a method of monitoring DNA sequences with such high sensitivity that a single molecule may be detected. Such sensitivity is achieved using an atomic force microscope (AFM) to measure surface forces. Modifying an AFM tip with a single strand of DNA allows the complementary strand (the target) to be recognized via hybridization to form the double helix. The occurrence of hybridization is determined by differences in surface force measurements compared with when only the single strand of DNA is present. In this way DNA samples can be analyzed without amplification; a major advance for DNA diagnostics.Read moreRead less
Liquid light: aqueous bio-sensing in microstructured polymer optical fibres. This project builds on Australia's world-leading position in the development of microstructured polymer optical fibres, and applies the unique benefits they provide to for ultra- sensitive bio-sensing. By using the microstructure to simultaneously confine light and liquid, microstructured optical fibres provide a unique platform for ultra-sensitive spectroscopy and structural studies of biomolecules in solution. The wor ....Liquid light: aqueous bio-sensing in microstructured polymer optical fibres. This project builds on Australia's world-leading position in the development of microstructured polymer optical fibres, and applies the unique benefits they provide to for ultra- sensitive bio-sensing. By using the microstructure to simultaneously confine light and liquid, microstructured optical fibres provide a unique platform for ultra-sensitive spectroscopy and structural studies of biomolecules in solution. The work has profound implications both for fundamental science and applications, particularly in medical diagnostics.Read moreRead less
Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye. Lipids provide a critical layer in the human tear film that retards evaporation and helps nourish and protect the eye. We will identify the molecules within this essential "oil slick" to better understand dry eye syndrome and the discomfort associated with wearing contact lenses. This may lead to new treatments for dry eye and novel technologies that provide greater comfort for the ~120,00 ....Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye. Lipids provide a critical layer in the human tear film that retards evaporation and helps nourish and protect the eye. We will identify the molecules within this essential "oil slick" to better understand dry eye syndrome and the discomfort associated with wearing contact lenses. This may lead to new treatments for dry eye and novel technologies that provide greater comfort for the ~120,000 Australians who wear contact lenses. This collaborative research directly supports the mission of a respected non-profit organisation (Institute for Eye Research) and will train scientists in world-leading analytical technologies that are essential to Australia's emerging biotechnology industries.Read moreRead less
Novel approach to study mechanisms of Na+ transport in plants using Lab on a Chip technology. A Lab on a Chip for sodium ion measurements in plants is proposed, offering a long overdue solution to the lack of appropriate techniques to study the mechanisms of sodium iron uptake, transport and compartmentation. Sodium ion transport is a key determinant of salt tolerance, but a good understanding of its transport mechanisms is lacking since no appropriate measurement tools are available. Using the ....Novel approach to study mechanisms of Na+ transport in plants using Lab on a Chip technology. A Lab on a Chip for sodium ion measurements in plants is proposed, offering a long overdue solution to the lack of appropriate techniques to study the mechanisms of sodium iron uptake, transport and compartmentation. Sodium ion transport is a key determinant of salt tolerance, but a good understanding of its transport mechanisms is lacking since no appropriate measurement tools are available. Using the system proposed here, sodium ion is separated from interfering ions, allowing fast and selective measurements. A series of ground breaking studies towards sodium ion uptake, transport and compartmentation in plants will be conducted using this Lab on a Chip.Read moreRead less
Functional nonlinear optical endoscopy - the third-generation optical endoscopy technology toward early cancer detection at a cellular level. The third-generation optical endoscopy technology can be used for a better understanding of nonlinear optical interaction with organ sites and thus for early cancer detection. Such a novel device will enable biomedical scientists to gain the fundamental knowledge needed to enable Australians to develop better medical strategies for health and productive li ....Functional nonlinear optical endoscopy - the third-generation optical endoscopy technology toward early cancer detection at a cellular level. The third-generation optical endoscopy technology can be used for a better understanding of nonlinear optical interaction with organ sites and thus for early cancer detection. Such a novel device will enable biomedical scientists to gain the fundamental knowledge needed to enable Australians to develop better medical strategies for health and productive lives. Since 1 in 3 Australians will feel the effects of cancers, development of portable nonlinear optical endoscopes is of national importance, in particular for rural Australia, and therefore improves the healthcare of human beings. The potential spin-off activity will lead to economic benefits from new R&D development.Read moreRead less