Attachment of Growth Factors to Pure, Plasma Modified and Coated Titanium Substrates. Titanium and its alloys are routinely used as medical and dental implants. Despite coating with hydroxyapatite, a material well known to improve implant fixation, many such implants fail because of lack of strong integration with bone. This proposal aims at achieving long-term stability of titanium implants through their surface modification and subsequent attachment of growth factors. The use of latter has alr ....Attachment of Growth Factors to Pure, Plasma Modified and Coated Titanium Substrates. Titanium and its alloys are routinely used as medical and dental implants. Despite coating with hydroxyapatite, a material well known to improve implant fixation, many such implants fail because of lack of strong integration with bone. This proposal aims at achieving long-term stability of titanium implants through their surface modification and subsequent attachment of growth factors. The use of latter has already been shown to help bone-implant integration. Successful project implementation will provide titanium implant surfaces that will help achieve speedier and improved implant fixation with long-term stability. Knowledge, expertise and techniques developed will help the industry partner expanding its research base and business and generating wealth in Australia. Training of world-class research students in the emerging field of biotechnology will be another major outcome.Read moreRead less
Development of a novel biodegradable ophthalmic biomaterial based on porous silicon. Within this interdisciplinary project, we will combine our diverse expertise towards the development of frontier technologies for control of stem cell behaviour on biodegradable scaffold materials. We will develop a novel ophthalmic bioimplant from porous silicon using topographical and chemical aspects of surface modification as well as immobilisation and/or incorporation of bioactive species such as growth fac ....Development of a novel biodegradable ophthalmic biomaterial based on porous silicon. Within this interdisciplinary project, we will combine our diverse expertise towards the development of frontier technologies for control of stem cell behaviour on biodegradable scaffold materials. We will develop a novel ophthalmic bioimplant from porous silicon using topographical and chemical aspects of surface modification as well as immobilisation and/or incorporation of bioactive species such as growth factors, to permit the growth and differentiation of mammalian stem cells. This project will result in biomaterials for the treatment of blinding diseases of the eye. Implanted into the limbus, bioimplants may ameliorate some common corneal diseases.Read moreRead less
Covalent Immobilisation of Growth Factors on Plasma Modified Titanium for Achieving Enhanced Bone Growth and Bonding in Implant Prosthetics. This project is aimed at improving the fixation of titanium implants by combining the surface technologies expertise of University of South Australia and Flinders University with TGR BioSciences's growth factors expertise. Plasma modified and hydroxyapatite-coated implant surfaces will be used for covalent immobilisation of growth factors via tethers with ....Covalent Immobilisation of Growth Factors on Plasma Modified Titanium for Achieving Enhanced Bone Growth and Bonding in Implant Prosthetics. This project is aimed at improving the fixation of titanium implants by combining the surface technologies expertise of University of South Australia and Flinders University with TGR BioSciences's growth factors expertise. Plasma modified and hydroxyapatite-coated implant surfaces will be used for covalent immobilisation of growth factors via tethers with tailored wettability and flexibility. This innovative strategy is expected to yield high retention of growth factor bioactivity and increased bone-implant integration for long-term implant stability. Knowledge, expertise and techniques developed will help TGR BioSciences expanding its research base and business. Training of students in the emerging field of nano-biotechnology will be another major outcome.Read moreRead less
The Risks And Benefits Of Contemporary Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$493,530.00
Summary
The number of hip replacements undertaken in Australia is steadily increasing. The most common complications of hip replacements are dislocation and loosening due to bone loss around the implant, requiring complex and expensive revision surgery. This study will investigate the incidence of dislocation and, using a new diagnostic imaging technique, the incidence and amount of bone loss around a relatively new prosthetic material, the outcomes of which are not known despite its increasing use.
Radiostereometric Analysis Of The Effect Of A Large Articulation On Prosthetic Wear And Migration After Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$192,186.00
Summary
At total hip replacement, there has been a recent trend to use prostheses with a larger ball and liner in the socket. This may decrease the risk of post-operative dislocation, but may also increase the amount of wear, leading to bone loss and loosening of prostheses, which may then require replacement. This project will use a special type of x-ray to determine whether wear and movement of these new prostheses is clinically acceptable, so that they can be used with confidence in patients.
A model of sex offender registration, monitoring, and risk management. This research will investigate the ways in which sexual offenders are managed in the community and identify the most effective means of preventing further offending, thereby promoting community safety.
Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. ....Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. The development of technological innovations based on fabricated nanomaterials, will also enhance capacity in frontier technology such as nanotechnology, and build Australia’s strength in using new biosensing technologies.Read moreRead less
Policing the Neighbourhood: Australian Police Peace-keeping, Capacity-building, and Development in Timor-Leste, Solomon Islands and Papua New Guinea. Australia's involvement in policing offshore is growing rapidly. Timor-Leste and the Solomon Islands, and shortly, Papua New Guinea, feature in these developments. The Australian Federal Police is now a key player in regional security and development. This study takes stock of this trend. Through three case studies, the project examines the grou ....Policing the Neighbourhood: Australian Police Peace-keeping, Capacity-building, and Development in Timor-Leste, Solomon Islands and Papua New Guinea. Australia's involvement in policing offshore is growing rapidly. Timor-Leste and the Solomon Islands, and shortly, Papua New Guinea, feature in these developments. The Australian Federal Police is now a key player in regional security and development. This study takes stock of this trend. Through three case studies, the project examines the grounds for providing assistance, the different cultural and political contexts in which assistance is taking place, the forms of that assistance, and the achievements and shortcomings of previous and current police assistance missions. It will also provide an analytical framework for future engagements of this nature.Read moreRead less
Private Security and Public Interest: Exploring Private Security Trends and Directions for Reform in the New Era of Plural Policing. This study will provide the first ever comprehensive assessment of private security and what it can and cannot offer society in terms of fair and effective order maintenance, crime prevention and law enforcement in Australia. Stemming from problems incurred by the sector, the research will address how governments should regulate the growing range of policing functi ....Private Security and Public Interest: Exploring Private Security Trends and Directions for Reform in the New Era of Plural Policing. This study will provide the first ever comprehensive assessment of private security and what it can and cannot offer society in terms of fair and effective order maintenance, crime prevention and law enforcement in Australia. Stemming from problems incurred by the sector, the research will address how governments should regulate the growing range of policing functions undertaken by private providers. It will also address the issue of how private police can best satisfy legal and justice criteria, meet the demands of accountability and develop mutually beneficial models of cooperation with the public sector. The research will recommend to policy-makers preferred 'plural' policing models for the 21st century.Read moreRead less
Analysing interactions within the criminal deportation system. This project aims to investigate the convergence of migration control and criminal justice by analysing pathways to criminal deportation. The project expects to generate new criminological understandings of deportation as a means of promoting community safety using interdisciplinary approaches that capture regional and metropolitan practice. Expected outcomes include knowledge of how information flows between migration control and cr ....Analysing interactions within the criminal deportation system. This project aims to investigate the convergence of migration control and criminal justice by analysing pathways to criminal deportation. The project expects to generate new criminological understandings of deportation as a means of promoting community safety using interdisciplinary approaches that capture regional and metropolitan practice. Expected outcomes include knowledge of how information flows between migration control and criminal justice agencies, and the implications for policing, courts, and prison administration. This should provide significant benefits for policy-makers and practitioners, by articulating emerging and unexplored practices that have major consequences for community safety, social cohesion and the rule-of-law.Read moreRead less