Superior Surgical Fixation Using A Novel Orthopaedic Expandable Fastener
Funder
National Health and Medical Research Council
Funding Amount
$414,076.00
Summary
Surgeons repair bone fractures using metal plates and screws. Sometimes the screws loosen and the surgery needs to be repeated. Expandable screws are stronger, but more difficult and sometimes impossible to remove. The research team will test a new type of screw that holds the bones together with greater strength (our current work shows 40% stronger) but can be removed easily if necessary. This grant will allow extensive mechanical testing in preparation for a first-in-human clinical trial.
Micro-elastography - A New Tool For Microscopic Intraoperative Tumour Margin Assessment In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$195,956.00
Summary
In breast cancer surgery, it is vital to completely remove the entire tumour. Unfortunately, in 30% of breast-conserving surgeries, re-excision is required because microscopic analysis after the surgery indicated some tumour had been missed. This has traumatic consequences for the patient and places a huge economic burden on the healthcare system. Using micro-elastography, we will enable the surgeon to detect small regions of tumour during the initial surgery. This probe may significantly reduce ....In breast cancer surgery, it is vital to completely remove the entire tumour. Unfortunately, in 30% of breast-conserving surgeries, re-excision is required because microscopic analysis after the surgery indicated some tumour had been missed. This has traumatic consequences for the patient and places a huge economic burden on the healthcare system. Using micro-elastography, we will enable the surgeon to detect small regions of tumour during the initial surgery. This probe may significantly reduce the number of additional surgeries required.Read moreRead less
Application Of Sutureless Technology 'SurgiLux' For Dura Mater Repair: A Proof Of Concept Study
Funder
National Health and Medical Research Council
Funding Amount
$213,125.00
Summary
A unique technology that combines biomaterials and lasers to effectively close and seal wounds could replace sutures in delicate surgery close to the brain. Wound closure in the cranium is still reliant upon sutures or 'stitches' and these have complications; a major one being leakage of cerebro spinal fluid (CSF). The application of 'SurgiLux' technology will both close and seal these wounds quickly and easily, with significant health and economic benefits.
Clinical Research Translation In Fluorescence-guided Surgery Of Brain Cancer: Developing A Surgical Endoscope With Enhanced Contrast
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This proposal aims to improve the life expectancy of brain cancer patients by developing a new neurosurgical optical imaging device. The technology will transform the recently developed fluorescence-guided surgery procedure, where the tumour is endowed with artificial fluorescence. Our state-of-the art technology will enhance the fluorescence detection beyond visual perception to help remove hard-to-detect small cancer cell clusters, resulting in more accurate surgical removal of tumours.
Development Of A New Surgical-guidance Tool For Intra-operative Tumour Margin Assessment In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$557,982.00
Summary
One third of breast cancer patients undergoing breast conserving surgery have insufficient tissue removed, resulting in an increased risk of recurrence. We have developed a high resolution optical imaging probe with the potential to detect small areas of cancer. It could be used to help guide the surgeon to remove all cancerous tissue from the patient. This grant will allow us to develop the probe to a stage that it can be used during surgery, and perform the world’s first clinical scans.
Development Of An Intra-Operative Tool For Tumour Margin Assessment During Surgery
Funder
National Health and Medical Research Council
Funding Amount
$599,472.00
Summary
The objective of this study is to develop and evaluate a surgical probe that uses novel terahertz technology to guide surgical excision. As an example, approximately 3,000 breast cancer patients per year require a second surgical procedure because of tumour identified close to the edge of tissue removed during surgery. There is a clinical need for an accurate, real-time and non-destructive technique to assess tumour margins during surgery. This tool could also be used for any surgery that requir ....The objective of this study is to develop and evaluate a surgical probe that uses novel terahertz technology to guide surgical excision. As an example, approximately 3,000 breast cancer patients per year require a second surgical procedure because of tumour identified close to the edge of tissue removed during surgery. There is a clinical need for an accurate, real-time and non-destructive technique to assess tumour margins during surgery. This tool could also be used for any surgery that requires preservation of normal tissue.Read moreRead less
Development Of Microscope-in-a-needle Devices For Improved Clinical Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$327,746.00
Summary
We have developed a new high-resolution optical imaging technology. The unique aspect of our research has been to redesign the imaging probe, miniaturising it to a few hundred microns in diameter, and encase it in a hypodermic needle – a ‘microscope-in-a-needle’. We are developing specific imaging probes to aid in the assessment of lung disease; the diagnosis of liver disease; and integrated into a brain biopsy needle to enable safer brain biopsies.
Three dimensional (3D) optical coherence tomography in cancer. This project will establish for the first time how well 3D optical coherence tomography, a form of medical imaging, can image cancer. Based on this, a version built into a needle will be developed which will enable extension much deeper into tissues than previously possible to image cancer and to guide related surgical procedures.