Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
Building bio-inspired smart nanochannels for virus detection. This project aims to harness high-precision silicon nanofabrication methods to create the next generation of bio-inspired viral biosensors. The new technology would enable prompt, cost-efficient, and accurate detection of virus contamination of our water and food supplies. The project plans to fabricate arrays of parallel double-layered nanochannels in silicon via templated etching, with surface functionalisation to display receptors. ....Building bio-inspired smart nanochannels for virus detection. This project aims to harness high-precision silicon nanofabrication methods to create the next generation of bio-inspired viral biosensors. The new technology would enable prompt, cost-efficient, and accurate detection of virus contamination of our water and food supplies. The project plans to fabricate arrays of parallel double-layered nanochannels in silicon via templated etching, with surface functionalisation to display receptors. These nanochannels are designed to act as size-selective filters for electrochemical and electrochemiluminescence sensing. The project plans to explore innovative signal amplification and multiplexing capabilities for ultrasensitive detection of norovirus and bacteriophages.Read moreRead less
A new angle on the coalescence of drops. Many processes depend on what happens when drops and/or bubbles collide with each other, or with the surfaces of other materials. Examples include inkjet printing, agricultural spraying, spray coating of paints, pharmaceutical formulation, stability of cosmetics and foodstuffs, formation of froths and foams, and flow of bubbly liquids. To control these processes, we need to understand how and why drops sometimes do and sometimes do not coalesce with each ....A new angle on the coalescence of drops. Many processes depend on what happens when drops and/or bubbles collide with each other, or with the surfaces of other materials. Examples include inkjet printing, agricultural spraying, spray coating of paints, pharmaceutical formulation, stability of cosmetics and foodstuffs, formation of froths and foams, and flow of bubbly liquids. To control these processes, we need to understand how and why drops sometimes do and sometimes do not coalesce with each other or adhere to surfaces. The knowledge gained in this project will enable improvements to be made in the efficiency of processes such as those listed above.Read moreRead less
Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely ....Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely collected in Australia's catchments and thereby better predict water quality behaviour. Proposed field studies aim to support this development. The outcomes sought are improved planning and management of water quality in our rivers, lakes and estuaries, improved health of these water bodies and improved water supplies.Read moreRead less
Smart hybrid nano-biomaterials that mimic the pharmaceutical food effect. Smart biomaterials will be developed which when taken orally will act in our gut to improve drug and vitamin uptake. The breakthrough science will drive new pharmaceuticals and nutraceuticals for the future health of Australia, and economic benefits will result through increased exposure to the global market for delivering biomolecules.
Harnessing lipid nano-assembly for next generation functional foods and pharmaceutical products. Nature assembles lipid molecules from our diet into useful structures in our gastrointestinal tract with remarkable precision and versatility. By understanding and harnessing these processes we can design new lipid-based nanomaterials leading to more effective functional foods and pharmaceutical products with reduced side effects.
The application of clumped isotope thermometry to the terrestrial environment. Clumped-isotope geochemistry, a novel method for measuring the temperature of formation of carbonate minerals, will be applied to terrestrial materials (soil carbonates, lake deposits and speleothems) from Australia and New Zealand. The method relates the abundance or 'clumping' of rare isotopes (for example, carbon dioxide of mass 47 as carbon-13, oxygen-18, oxygen-16) extracted from carbonates to their formation tem ....The application of clumped isotope thermometry to the terrestrial environment. Clumped-isotope geochemistry, a novel method for measuring the temperature of formation of carbonate minerals, will be applied to terrestrial materials (soil carbonates, lake deposits and speleothems) from Australia and New Zealand. The method relates the abundance or 'clumping' of rare isotopes (for example, carbon dioxide of mass 47 as carbon-13, oxygen-18, oxygen-16) extracted from carbonates to their formation temperature and is independent of the oxygen-18:oxygen-16 value of the host water from which the mineral precipitated. The materials to be investigated span the Last Glacial-Interglacial Transition and will provide robust past temperature estimates and the delta-oxygen-18 values of waters, thereby permitting hydrological balances (for example, precipitation/evaporation) to be constructed. Read moreRead less
Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk ass ....Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.Read moreRead less
Nanoscale characterisation of the dynamics of artificial lipid membranes - model systems for drug binding studies. This project will see the development of artificial membranes replicating the physiological behaviour of cell membranes providing a novel platform for in vitro drug evaluation clearing the way for the development of effective new therapies with fewer side effects.