Patterned assemblies of molecules on surfaces. Because of their redox and photophysical properties, artificial porphyrin systems have been designed for applications such as light-harvesting antennae, catalysts and sensors. Control of molecular orientation is required in order to construct practical devices, and in this project methods of assembling porphyrins on surfaces in well-defined patterns will be developed. Sophisticated methods will be used to characterise the films produced in these w ....Patterned assemblies of molecules on surfaces. Because of their redox and photophysical properties, artificial porphyrin systems have been designed for applications such as light-harvesting antennae, catalysts and sensors. Control of molecular orientation is required in order to construct practical devices, and in this project methods of assembling porphyrins on surfaces in well-defined patterns will be developed. Sophisticated methods will be used to characterise the films produced in these ways, in order to provide the information necessary to refine procedures and design new molecules suitable for advanced applications. Expected outcomes are new methods and architectures that can ultimately yield devices that act at the molecular level.Read moreRead less
Atomic-Scale Engineering of Bioactive Organic Molecules on Surfaces. Advances in scanning probe microscopy (SPM) have enabled the precise engineering of matter at surfaces. The ability to image and track changes at surfaces is simply staggering, but the frontier of molecules with pharmaceutical and agrichemical importance remains unexplored. This interdisciplinary project aims to synthesise fundamental molecules and reveal molecular rearrangement pathways utilising SPM. Expected outcomes of this ....Atomic-Scale Engineering of Bioactive Organic Molecules on Surfaces. Advances in scanning probe microscopy (SPM) have enabled the precise engineering of matter at surfaces. The ability to image and track changes at surfaces is simply staggering, but the frontier of molecules with pharmaceutical and agrichemical importance remains unexplored. This interdisciplinary project aims to synthesise fundamental molecules and reveal molecular rearrangement pathways utilising SPM. Expected outcomes of this project include new methods to couple molecules otherwise unobtainable by traditional means and fundamental knowledge of molecular manipulation and chemical structure. This aims to provide significant benefits, such as the translation of new chemical principles to academic and industrial laboratories.Read moreRead less
Engineering biomimetic lubrication with mucin. Engineering coatings for water to be an effective lubricant is a significant challenge. The project seeks to emulate how nature builds highly lubricating water-rich polymer films on biological surfaces. This is intended to be achieved by directing the self-assembly of mucin macromolecules onto polymer brushes attached to a substrate, and then cross-linking the constituents to obtain a hydrated gel-like lubricating coating. This research is expected ....Engineering biomimetic lubrication with mucin. Engineering coatings for water to be an effective lubricant is a significant challenge. The project seeks to emulate how nature builds highly lubricating water-rich polymer films on biological surfaces. This is intended to be achieved by directing the self-assembly of mucin macromolecules onto polymer brushes attached to a substrate, and then cross-linking the constituents to obtain a hydrated gel-like lubricating coating. This research is expected to provide new insights on the mechanisms by which mucin-rich fluids lubricate and protect biosurfaces, which is important to human health, nutrition and well-being. It may also lead to new discoveries for engineering surface coatings for biomaterials and nanomaterials.Read moreRead less
Graded Biomaterial for Articular Cartilage Replacement. Osteoarthritis is a major health and economical burden on the Australian community which can be addressed in part by providing a viable option for effective clinical treatment. 34% of people over the age of 50 suffer from osteoarthritis, predominantly the knee. The development of a biomaterial to enable repair of articular cartilage through minor surgical procedures will release resources at point of care. Current biomaterial options are st ....Graded Biomaterial for Articular Cartilage Replacement. Osteoarthritis is a major health and economical burden on the Australian community which can be addressed in part by providing a viable option for effective clinical treatment. 34% of people over the age of 50 suffer from osteoarthritis, predominantly the knee. The development of a biomaterial to enable repair of articular cartilage through minor surgical procedures will release resources at point of care. Current biomaterial options are still in infancy and an Australian based product would benefit the Australian economy as well as Australia's international standing within the biomaterials community.Read moreRead less
Multiscale viscoelastic lubrication of soft matter systems. The project aims to develop new principles of viscoelastic lubrication in soft contacts. New insights into friction behaviour arising from complex fluid-substrate interactions are expected to be generated using techniques and interdisciplinary approaches that bridge rheology, tribology and surface science. The intended outcome is a lubrication model that interprets the contribution of viscoelastic effects occurring across multiple lengt ....Multiscale viscoelastic lubrication of soft matter systems. The project aims to develop new principles of viscoelastic lubrication in soft contacts. New insights into friction behaviour arising from complex fluid-substrate interactions are expected to be generated using techniques and interdisciplinary approaches that bridge rheology, tribology and surface science. The intended outcome is a lubrication model that interprets the contribution of viscoelastic effects occurring across multiple length and time scales. This should provide significant benefits to diverse fields including advanced materials and complex fluids, engineering tribology, bio-lubrication and food structure design.Read moreRead less
Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk ass ....Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.Read moreRead less
DEVELOPMENT OF A NOVEL BIOMATERIAL FOR BONE TISSUE ENGINEERING. Tissue engineering of bone is emerging as a viable therapy for treating large defects in load-bearing bone. We wish to develop methods for combining novel heparan sulphate molecules (known to deliver growth factors to cell surfaces and thereby cause changes in bone cell phenotype) with load-bearing, macro-porous, biodegradable mineral/polymer biomaterials. Through the study of release profiles, protein adsorption and cell responses ....DEVELOPMENT OF A NOVEL BIOMATERIAL FOR BONE TISSUE ENGINEERING. Tissue engineering of bone is emerging as a viable therapy for treating large defects in load-bearing bone. We wish to develop methods for combining novel heparan sulphate molecules (known to deliver growth factors to cell surfaces and thereby cause changes in bone cell phenotype) with load-bearing, macro-porous, biodegradable mineral/polymer biomaterials. Through the study of release profiles, protein adsorption and cell responses to these derivatised biomaterials, a novel approach to bone replacement materials can be developed.Read moreRead less
Programming anisotropy into responsive soft materials. The project aims to generate viscoelastic soft materials with programmable anisotropy using aqueous suspensions of colloidal rods that have tunable surface coatings. The project expects to generate new knowledge in the rheology and structural characteristics of this unique class of materials. A key innovation is the use of charge-directed polymer self-assembly to control colloidal interactions, suspension rheology and phase behaviour. The in ....Programming anisotropy into responsive soft materials. The project aims to generate viscoelastic soft materials with programmable anisotropy using aqueous suspensions of colloidal rods that have tunable surface coatings. The project expects to generate new knowledge in the rheology and structural characteristics of this unique class of materials. A key innovation is the use of charge-directed polymer self-assembly to control colloidal interactions, suspension rheology and phase behaviour. The intended outcome is spatial control over the orientation of nanostructures, potentially mimicking the structural hierarchy found in nature. This should provide significant benefits to the creation of viscoelastic materials with complex rheology as well as structural, mechanical and optical heterogeneity.Read moreRead less
Unintentional surfactant facilitated solubilisation and transport of apparently immobile chemicals. This research will improve qualitative and quantitative understanding on surfactant facilitated transport processes of apparently immobile contaminants. The project's goal is to provide a modelling approach that ultimately can be applied to assess and predict groundwater and offsite contamination risks in areas where surfactants are commonly used.
Extreme soil acidification and metal release risks from increasing drought. The project aims to study the effects of drought on pH and metal speciation in soils, and develop tools to assess current and future risks. Social and economic well-being depends on good soil and water quality. Climate change makes droughts more frequent and severe, which could cause soil acidification (pH<4) and metal release in many regions. The project will integrate experimental data on the effects of drought on soil ....Extreme soil acidification and metal release risks from increasing drought. The project aims to study the effects of drought on pH and metal speciation in soils, and develop tools to assess current and future risks. Social and economic well-being depends on good soil and water quality. Climate change makes droughts more frequent and severe, which could cause soil acidification (pH<4) and metal release in many regions. The project will integrate experimental data on the effects of drought on soil geochemistry with hydro-geochemical models, and apply these to national-scale predictions. The intended outcomes are improved management and preparedness for droughts and new research directions for geochemistry.Read moreRead less