Asymmetric Synthesis and Biological Evaluation of Bioactive Alkaloids and their Analogues. We propose to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The methodolo ....Asymmetric Synthesis and Biological Evaluation of Bioactive Alkaloids and their Analogues. We propose to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The methodology and products developed may have potential pharmaceutical and agricultural applications from which the country could benefit from in the future. This project would help developed skilled people that may develop innovative outcomes in the future, especially in the developing pharmaceutical and biotechnology industries in Australia.Read moreRead less
Stereoselective Synthesis of Bioactive Alkaloids for Structure Elucidation and Drug Discovery. It is proposed to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The m ....Stereoselective Synthesis of Bioactive Alkaloids for Structure Elucidation and Drug Discovery. It is proposed to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The methodology and products developed are likely to have potential pharmaceutical and agricultural applications from which the country could benefit in the future. This project will train skilled people who may develop innovative outcomes in the future, especially in the developing pharmaceutical and biotechnology industries in Australia.Read moreRead less
Large Scale Production of Stemona Alkaloids for Agricultural Applications and New Drug Discovery. The Stemona alkaloids form a large group of natural products that have significant potential as agricultural and pharmaceutical drugs. Extracts of these natural products have many applications in traditional medicine and as insecticides in Asia. We propose to develop innovative methods for the large scale production and synthesis of these bioactive alkaloids. The methodology and products developed ....Large Scale Production of Stemona Alkaloids for Agricultural Applications and New Drug Discovery. The Stemona alkaloids form a large group of natural products that have significant potential as agricultural and pharmaceutical drugs. Extracts of these natural products have many applications in traditional medicine and as insecticides in Asia. We propose to develop innovative methods for the large scale production and synthesis of these bioactive alkaloids. The methodology and products developed may have potential pharmaceutical and agricultural applications from which the country could benefit in the future. This project would help develop skilled people who may produce innovative outcomes in the future, especially in the developing pharmaceutical and biotechnology industries in Australia.Read moreRead less
The unfolding story of the 2009 Adelaide heatwave: risk factors for mortality and morbidity. This project will conduct a case control study in Adelaide to explore the risk factors of extra health burden related to the 2009 heatwave. Given the prediction of more extreme heat events, this study will provide important information for policy makers and service providers to assist in the development of more resilient communities to climate change.
Water, carbon, and economics: resolving complex linkages for river health. By linking landscapes into our emerging low-carbon economy, this project will investigate how land management practices can be improved through payments for ecosystem services. With a focus on water and carbon, the main goal is to develop mechanisms to support integrated land and water management at the catchment scale.
Making Green Guard® greener: enhancing the efficacy of a biopesticide. The project aims to identify naturally occurring micro-organisms to increase the effectiveness of Green Guard ®, which is a biopesticide used against the Australian plague locust. The project will use next-generation sequencing and other molecular techniques to potentially identify candidate microbes or combinations of microbes that can be added to Green Guard to enhance locust susceptibility. The project also aims to quantif ....Making Green Guard® greener: enhancing the efficacy of a biopesticide. The project aims to identify naturally occurring micro-organisms to increase the effectiveness of Green Guard ®, which is a biopesticide used against the Australian plague locust. The project will use next-generation sequencing and other molecular techniques to potentially identify candidate microbes or combinations of microbes that can be added to Green Guard to enhance locust susceptibility. The project also aims to quantify the interactive impact of temperature and nutrition on immune function, disease resistance and host-plant quality of plague locusts; and to explore the combined effects of temperature, habitat and Green Guard, in combination with candidate microbes or pathogens, on the behaviour and collective movement of locusts. It is anticipated that this will have implications for management and control strategies.Read moreRead less