Fungal Ribosomally Synthesised and Post-translationally Modified Peptides. Fungi produce an array of molecules called secondary metabolites (SMs) that impact on everyday life (e.g. penicillin). This project aims to investigate a new class of fungal peptide SMs called RiPPs which are structurally unique from existing molecules and offer the exciting prospect of harbouring new and novel biological activities. This project expects to discover the mechanisms of RiPP synthesis and their biological ro ....Fungal Ribosomally Synthesised and Post-translationally Modified Peptides. Fungi produce an array of molecules called secondary metabolites (SMs) that impact on everyday life (e.g. penicillin). This project aims to investigate a new class of fungal peptide SMs called RiPPs which are structurally unique from existing molecules and offer the exciting prospect of harbouring new and novel biological activities. This project expects to discover the mechanisms of RiPP synthesis and their biological roles in plant pathogenic fungi, and uncover and engineer novel RiPPs with desired bioactivities. The expected outcome from this project will be a seminal advance in fungal SM biology which should provide significant benefits through the generation of exciting new lead molecules for the agricultural and medical industries.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100282
Funder
Australian Research Council
Funding Amount
$475,181.00
Summary
Delivering breeding-oriented genetic tools for cereal disease resistance. This project will focus specifically on delivering the genetic tools to the industry partner to assist its wheat and barley breeders to increase the accuracy and efficiency of incorporating the durable wheat stripe rust disease and barley leaf rust disease resistance into their core germplasm collections, respectively. The expected outcomes will also contribute to filling our knowledge gap in understanding the cereal rust ....Delivering breeding-oriented genetic tools for cereal disease resistance. This project will focus specifically on delivering the genetic tools to the industry partner to assist its wheat and barley breeders to increase the accuracy and efficiency of incorporating the durable wheat stripe rust disease and barley leaf rust disease resistance into their core germplasm collections, respectively. The expected outcomes will also contribute to filling our knowledge gap in understanding the cereal rust innate immune system and benefit other cereal fungal pathosystems. The wide application of the expected outcomes from the proposed project will reduce the utilisation of fungicides and subsequently will subsequently contribute to the resilience of cereal crops and sustainable global food security.Read moreRead less
Does plasma membrane perception of 2,4-D influence auxin resistance? This project aims to investigate the role of the cell membrane in synthetic auxin herbicide resistance by analysing the functions and interaction partners of candidate resistance proteins. It is expected that this project will generate new knowledge about the very early response of plants to auxin and the difference between susceptible and resistant weeds in perceiving auxin herbicides. Expected outcomes of this project include ....Does plasma membrane perception of 2,4-D influence auxin resistance? This project aims to investigate the role of the cell membrane in synthetic auxin herbicide resistance by analysing the functions and interaction partners of candidate resistance proteins. It is expected that this project will generate new knowledge about the very early response of plants to auxin and the difference between susceptible and resistant weeds in perceiving auxin herbicides. Expected outcomes of this project include the identification of potential herbicide synergists and a greater understanding of how weeds develop resistance to auxin herbicides. This should benefit Australian grain growers by providing more effective weed control options and lessening the amount of unnecessarily-applied herbicide in the environment.Read moreRead less