New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput anal ....New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput analytical cultivation, molecular networking, and chemical and biological analyses, expected outcomes include an enhanced ability to explore and exploit valuable chemistry hidden within microbial genomes, leading to the discovery of new classes of natural antiparasitic to safeguard livestock.
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Robust Defences against Adversarial Machine Learning for UAV Systems. This project aims to investigate robust defences for Unmanned Aerial Vehicle (UAV) systems to protect them against adversarial Machine Learning (ML) attacks. This project expects to generate new knowledge in the area of cybersecurity using innovative approaches to safeguard UAV systems from attacks that exploit vulnerabilities in ML models. The expected outcomes of this project include improve techniques for understanding and ....Robust Defences against Adversarial Machine Learning for UAV Systems. This project aims to investigate robust defences for Unmanned Aerial Vehicle (UAV) systems to protect them against adversarial Machine Learning (ML) attacks. This project expects to generate new knowledge in the area of cybersecurity using innovative approaches to safeguard UAV systems from attacks that exploit vulnerabilities in ML models. The expected outcomes of this project include improve techniques for understanding and developing robust ML models and enhanced capacity to design secure UAV systems. This should provide significant benefits, such as improving the security of UAV technology and increasing the reliable use of UAVs for transport and logistics services to support urban and regional communities in Australia.Read moreRead less
New vaccines and diagnostics to control viral disease in farmed crocodiles. Infection of farmed crocodiles with West Nile virus (WNV) causes lesions in the skin that render the hides unsuitable for high quality leather products. This results in >$20 million lost revenue to the Australian crocodile industry annually. We have developed a novel technology to generate safe and effective vaccines and diagnostic tests for WNV in animals. We aim to 1) conduct vaccine trials in farmed crocodiles to dete ....New vaccines and diagnostics to control viral disease in farmed crocodiles. Infection of farmed crocodiles with West Nile virus (WNV) causes lesions in the skin that render the hides unsuitable for high quality leather products. This results in >$20 million lost revenue to the Australian crocodile industry annually. We have developed a novel technology to generate safe and effective vaccines and diagnostic tests for WNV in animals. We aim to 1) conduct vaccine trials in farmed crocodiles to determine the optimum dose formulation and immunisation regime to provide long-lived protection against WNV disease; 2) validate pen-side tests to rapidly diagnose WNV infection in crocodiles on farms; and 3) transfer the technology to a manufacturing facility to ensure a commercial supply of the vaccines and diagnostic tests. Read moreRead less
Novel biological and genetic disease control tools for the barley industry. This project places Australian barley breeders at the forefront of disease resistance by providing them with novel tools to develop varieties with enhanced protection against fungal diseases. The aims are to produce fungal strains with multiple virulence genes for fast and cost-effective testing of barley lines, untangle the fungal/host gene interaction for resistance breeding and identify new sources of resistance. The ....Novel biological and genetic disease control tools for the barley industry. This project places Australian barley breeders at the forefront of disease resistance by providing them with novel tools to develop varieties with enhanced protection against fungal diseases. The aims are to produce fungal strains with multiple virulence genes for fast and cost-effective testing of barley lines, untangle the fungal/host gene interaction for resistance breeding and identify new sources of resistance. The outcomes will lead to the commercialisation by Australian breeding companies of barley varieties with durable fungal resistance. This will benefit the Australian economy by providing sustainability and protection for barley breeding thereby significantly reducing crop losses for this important global agricultural commodity.Read moreRead less
More than a reserve? Measuring the benefits of private protected areas. This project aims to develop a framework for understanding the full suite of benefits derived from privately protected areas in Australia. It will develop and test a new interdisciplinary approach to measure the ecological, socio-cultural, and economic benefits of protected areas to both human and non-human beneficiaries. Outcomes will include a systematic process to effectively gather data, analyse, and report on the full s ....More than a reserve? Measuring the benefits of private protected areas. This project aims to develop a framework for understanding the full suite of benefits derived from privately protected areas in Australia. It will develop and test a new interdisciplinary approach to measure the ecological, socio-cultural, and economic benefits of protected areas to both human and non-human beneficiaries. Outcomes will include a systematic process to effectively gather data, analyse, and report on the full suite of benefits derived from protected areas. The framework will provide a robust evidence base for the range of benefits provided by private protected areas. This will be vital to manage and grow Australia’s protected area network to reduce biodiversity and environmental declines, and meet international commitments.Read moreRead less
Reducing the health & economic burden of Campylobacter using a live vaccine. The aim of the project is to develop a vaccine to reduce Campylobacter bacteria in chickens. Campylobacters cause disease in both poultry and humans. Poultry products are the most common source of human infections. By reducing Campylobacter in poultry, the transfer to humans will be reduced. The expected outcomes arising from this work will be a reduction of the economic burden of poultry losses, in an Australian indust ....Reducing the health & economic burden of Campylobacter using a live vaccine. The aim of the project is to develop a vaccine to reduce Campylobacter bacteria in chickens. Campylobacters cause disease in both poultry and humans. Poultry products are the most common source of human infections. By reducing Campylobacter in poultry, the transfer to humans will be reduced. The expected outcomes arising from this work will be a reduction of the economic burden of poultry losses, in an Australian industry valued at $2.8 billion/year, and an improvement in food safety, thus helping to reduce the burden of foodborne illness, estimated to be $1.2 billion dollars/year. This project is, therefore, poised to benefit the Australian economy, specifically primary producers and the general public, by targeted vaccination of poultry.Read moreRead less
Chemicals in compostable food contact paper packaging materials. The aim of this project is to understand the presence of persistent chemicals in recyclable and compostable food contact materials (FCMs). These types of products are destined for recycling or biowaste streams that bridge the gap from take-make-dispose and into a circular economy. Currently, the knowledge of the chemicals in these products is limited but we need to ensure that they are safe and do not unnecessarily contaminate reso ....Chemicals in compostable food contact paper packaging materials. The aim of this project is to understand the presence of persistent chemicals in recyclable and compostable food contact materials (FCMs). These types of products are destined for recycling or biowaste streams that bridge the gap from take-make-dispose and into a circular economy. Currently, the knowledge of the chemicals in these products is limited but we need to ensure that they are safe and do not unnecessarily contaminate resource recovery streams. It is expected that this project will develop a framework that could be used by industry and government to prevent chemicals of concern persisting in a circular economy, providing environmental and economic benefits through reduced risk of chemical exposure and unnecessary remediation costs.Read moreRead less
Eco-friendly pesticides for crop protection. The aims of the project are to develop robust methods for measuring bioactive pesticidal molecules in butterfly pea cultivars, characterise their modes of action, determine the exposure and persistence of these molecules in field runoff and waterways and, in the longer term, develop butterfly pea cultivars with optimised bioactivity and safety. The major outcome of the project is the generation of new knowledge that will contribute to the development ....Eco-friendly pesticides for crop protection. The aims of the project are to develop robust methods for measuring bioactive pesticidal molecules in butterfly pea cultivars, characterise their modes of action, determine the exposure and persistence of these molecules in field runoff and waterways and, in the longer term, develop butterfly pea cultivars with optimised bioactivity and safety. The major outcome of the project is the generation of new knowledge that will contribute to the development of novel antifungal and insecticidal agents. This outcome is significant as there is a huge need for new pesticidal agents that exhibit wide safety margins, reduce problems associated with resistance to existing treatments, and that are safe for the environment.Read moreRead less
Plant cyclotides as novel sustainable tools for crop protection . This project between the University of Queensland and Syngenta, a top-tier agricultural biotech company, aims at developing new crop protection technologies based on peptides. Insecticides are essential to meet the 60% increase in food production goal set by the UN but long-term exposure to traditional insecticides can harm beneficial pollinating insect populations. Expected outcomes include an exciting new insecticide technology ....Plant cyclotides as novel sustainable tools for crop protection . This project between the University of Queensland and Syngenta, a top-tier agricultural biotech company, aims at developing new crop protection technologies based on peptides. Insecticides are essential to meet the 60% increase in food production goal set by the UN but long-term exposure to traditional insecticides can harm beneficial pollinating insect populations. Expected outcomes include an exciting new insecticide technology based on natural plant defense peptides, the cyclotides, which has potential to revolutionise crop protection, leading to safer products for the environment. Benefits from the technology include a reduction in toxic insecticide residues, precision targetted applications and agrichemicals that degrade without trace.Read moreRead less
Australia’s first Green Biopharm . Protein-based medicines and vaccines represent the fastest growing sector of the pharmaceutical market, but their production by Australian small and medium enterprises is prohibited by the high infrastructure and operating costs of traditional manufacturing systems. This project aims to develop advanced methods to produce protein-based medicines using a native plant. The power of this technology will be demonstrated by making a biologic anti-parasite treatment, ....Australia’s first Green Biopharm . Protein-based medicines and vaccines represent the fastest growing sector of the pharmaceutical market, but their production by Australian small and medium enterprises is prohibited by the high infrastructure and operating costs of traditional manufacturing systems. This project aims to develop advanced methods to produce protein-based medicines using a native plant. The power of this technology will be demonstrated by making a biologic anti-parasite treatment, as an alternative to outdated chemical treatments. Expected outcomes include a unique scalable technology which will support Australia's sovereign capacity to produce high-value proteins, rapidly, affordably, and at scale, and with less complexity than current plant-based systems. Read moreRead less