Porous Mineral Formulations for Controlled-Release Applications. The controlled release of biologically active agents from host materials is a process that is used routinely in pharmaceuticals delivery but has received only limited attention in large-scale, low-cost areas such as the agrochemicals industry. Here we identify a number of rare tubular mineral phases as having great potential for low-cost controlled release. These little-studied minerals, for which high quality deposits exist in Aus ....Porous Mineral Formulations for Controlled-Release Applications. The controlled release of biologically active agents from host materials is a process that is used routinely in pharmaceuticals delivery but has received only limited attention in large-scale, low-cost areas such as the agrochemicals industry. Here we identify a number of rare tubular mineral phases as having great potential for low-cost controlled release. These little-studied minerals, for which high quality deposits exist in Australia, consist of hollow tubules of nanoscale dimension. This project involves the first ever studies of the kinetics of guest release from these fascinating hosts, and promises to generate important new technologies in agrochemical delivery.Read moreRead less
Development of environmentally-friendly bioinsecticides for control of Australian crop pests. Insect pests cause over $3 billion of damage each year to Australian crops. Current insecticides are becoming less effective, and they often have adverse environmental impacts. This project aims to develop a new generation of environmentally-friendly insecticides that can be used to control insect pests on farms and around the home and garden.
Defining domains within Mycoplasma hyopneumoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine. Over 90% of Australian commercial pig production facilities are affected by Mycoplasma hyopneumoniae, the causative agent of swine enzootic pneumonia. This disease causes economic losses in Australia of over $20 million per annum and up to $1 billion per annum in major swine rearing countries worldwide. This project will determine the p ....Defining domains within Mycoplasma hyopneumoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine. Over 90% of Australian commercial pig production facilities are affected by Mycoplasma hyopneumoniae, the causative agent of swine enzootic pneumonia. This disease causes economic losses in Australia of over $20 million per annum and up to $1 billion per annum in major swine rearing countries worldwide. This project will determine the protective efficacy of new generation vaccines against M. hyopneumoniae, which aim to block the colonisation process and prevent disease .Read moreRead less
Identification and characterisation of Mycoplasma hyopneumoniae surface-molecules that interact with the host epithelium. Mycoplasma hyponeumoniae causes porcine enzootic pneumonia, a disease that significantly impacts swine production. Current vaccines are unable to prevent colonisation of the respiratory tract and are costly to produce and administer. The expression of microbial adhesins that mediate adherence to the extracellular matrix is considered the initial step in host colonisation for ....Identification and characterisation of Mycoplasma hyopneumoniae surface-molecules that interact with the host epithelium. Mycoplasma hyponeumoniae causes porcine enzootic pneumonia, a disease that significantly impacts swine production. Current vaccines are unable to prevent colonisation of the respiratory tract and are costly to produce and administer. The expression of microbial adhesins that mediate adherence to the extracellular matrix is considered the initial step in host colonisation for many bacterial pathogens. We propose to identify M. hyopneumoniae cell surface moleculaes that interact with components of the extracellular matrix. Targetting these cell surface molecules will lead to therapeutics that prevent disease and block colonisation, eventually eradicating the host pathogen from pig production facilities.Read moreRead less
Attract and reward: a novel approach to enhancing biological control of crop pests. Pests cause serious damage to Australia's agricultural crops. Current control relies heavily on synthetic pesticides. This project will develop novel products based on natural plant compounds to attract beneficial insects into crops where they will be supported with nectar, pollen and shelter to maximise their lifespan, reproduction, residency. This use of Australia's beneficial insect biodiversity will provide ....Attract and reward: a novel approach to enhancing biological control of crop pests. Pests cause serious damage to Australia's agricultural crops. Current control relies heavily on synthetic pesticides. This project will develop novel products based on natural plant compounds to attract beneficial insects into crops where they will be supported with nectar, pollen and shelter to maximise their lifespan, reproduction, residency. This use of Australia's beneficial insect biodiversity will provide novel pest control options to help transform the vegetable and grape industries. The work will reduce reliance on conventional pesticides; thereby contributing towards Australia's environmental sustainability and providing healthier foodstuffs. Read moreRead less
Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. This project aims to optimise the formulation of novel fluke vaccine antigens by constructing combination hybrid recombinant antigens and using a protein adjuvant to improve immunogenicity, and test new antigens expressed in young flukes as vaccines and evaluate their ability to synergise with hybrid vaccines. Fasciola (fluke) infections cause seriou ....Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. This project aims to optimise the formulation of novel fluke vaccine antigens by constructing combination hybrid recombinant antigens and using a protein adjuvant to improve immunogenicity, and test new antigens expressed in young flukes as vaccines and evaluate their ability to synergise with hybrid vaccines. Fasciola (fluke) infections cause serious economic losses to livestock production and fluke drug resistance threatens control, so new therapies such as a vaccine are needed. These vaccines should be evaluated in cattle trials. The major outcome plan is validation of hybrid antigens for commercial vaccine development for fluke control in cattle, leading to more sustainable beef and milk production in Australia.Read moreRead less
Mechanisms of antifungal resistance in blackleg disease of canola. This project aims to determine how fungicide resistance evolves in the fungus Leptosphaeria maculans, the major pathogen of the oilseed crop canola. Global food production has become more reliant on the use of antifungal agents to protect crops, however these advances are now threatened by the emergence of drug-resistant microbes. The knowledge generated by this project will be used to reduce the risk of resistance evolving in po ....Mechanisms of antifungal resistance in blackleg disease of canola. This project aims to determine how fungicide resistance evolves in the fungus Leptosphaeria maculans, the major pathogen of the oilseed crop canola. Global food production has become more reliant on the use of antifungal agents to protect crops, however these advances are now threatened by the emergence of drug-resistant microbes. The knowledge generated by this project will be used to reduce the risk of resistance evolving in populations of the blackleg fungus. This will have economic benefits through ensuring increased canola yields, while providing health and environmental benefits through minimisation of use of fungicides.Read moreRead less
Development of a novel, non-chemical technique based on the EppoMNPV baculovirus for the control of the lightbrown apple moth. Lightbrown apple moth (LBAM) is a serious pest of many horticultural crops in Australia, costing the economy about $21 M pa. Methods for controlling LBAM have relied on the use of insecticides. However, the pest has developed resistance to a wide range of chemicals used against it. This proposal aims to assess the potential of the EppoMNPV polyhedrosis virus as an alt ....Development of a novel, non-chemical technique based on the EppoMNPV baculovirus for the control of the lightbrown apple moth. Lightbrown apple moth (LBAM) is a serious pest of many horticultural crops in Australia, costing the economy about $21 M pa. Methods for controlling LBAM have relied on the use of insecticides. However, the pest has developed resistance to a wide range of chemicals used against it. This proposal aims to assess the potential of the EppoMNPV polyhedrosis virus as an alternative to insecticides for its control. Successful development of the virus will provide an environmentally benign alternative to insecticides that can be used to control LBAM in a range of different circumstances including broadacre and organic production.Read moreRead less
Autonomous tracking and predictive modelling of Australian plague locust migratory band movement. We will use advances in robotics, engineering, mathematics and biology to develop a new computer model for the control of one of the world's most damaging pest insects: locusts. Autonomous aerial robotic systems will be used to collect data on Australian plague locusts travelling in devastating migratory bands. These data on band movement and the behaviour of individual locusts within the band will ....Autonomous tracking and predictive modelling of Australian plague locust migratory band movement. We will use advances in robotics, engineering, mathematics and biology to develop a new computer model for the control of one of the world's most damaging pest insects: locusts. Autonomous aerial robotic systems will be used to collect data on Australian plague locusts travelling in devastating migratory bands. These data on band movement and the behaviour of individual locusts within the band will be used to develop a particle physics-inspired predictive model of migratory band movement, which will be used to optimise locust control operations. Economic, environmental and social benefits will arise through reductions in the amount of time, money, manpower and insecticides necessary to combat locust outbreaks.Read moreRead less
Topical and cryoanaesthesia for livestock husbandry. The livestock industries contribute $15billion annually to Australia's economy, playing a vital role in rural communities. However we must respond to changing demands of our customers, by complementing our competitive disease-free advantage with welfare-conscious production systems. This project will address the threat of growing international demands for improved animal welfare in farming. We will provide research and technical solutions, pro ....Topical and cryoanaesthesia for livestock husbandry. The livestock industries contribute $15billion annually to Australia's economy, playing a vital role in rural communities. However we must respond to changing demands of our customers, by complementing our competitive disease-free advantage with welfare-conscious production systems. This project will address the threat of growing international demands for improved animal welfare in farming. We will provide research and technical solutions, providing pain mangement products for on-farm use that will reduce animal suffering during routine husbandry interventions. The project offers significant benefits for producers by protecting their industries against the threats of a welfare embargo on our livestock products. Read moreRead less