New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput anal ....New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput analytical cultivation, molecular networking, and chemical and biological analyses, expected outcomes include an enhanced ability to explore and exploit valuable chemistry hidden within microbial genomes, leading to the discovery of new classes of natural antiparasitic to safeguard livestock.
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Innovation in agricultural sector Green House Gas abatement in NSW. This project aims to develop a land sector greenhouse gas abatement, food production and environmental economics model for NSW. We expect to identify innovation in carbon payment policy and brokerage business models to achieve agricultural GHG abatement, while simultaneously improving sustainability. Expected outcomes include evaluation of the innovations of expert landholders, related businesses and governments to find ways to ....Innovation in agricultural sector Green House Gas abatement in NSW. This project aims to develop a land sector greenhouse gas abatement, food production and environmental economics model for NSW. We expect to identify innovation in carbon payment policy and brokerage business models to achieve agricultural GHG abatement, while simultaneously improving sustainability. Expected outcomes include evaluation of the innovations of expert landholders, related businesses and governments to find ways to influence land use decisions. This should provide significant benefits to landholders, governments involved in land management and the public through increased productivity, profitability, biodiversity and ecosystem health in the context of future climate, agricultural commodity and carbon market uncertainties.Read moreRead less
Deep Learning Attacks and Active Defences: A Cybersecurity Perspective. The belief that deep learning technology is imperative for economic development, military control, and strategic competitiveness has accelerated its development across the globe. However, experience has revealed the disappointing fact that deep learning models are vulnerable to a range of security attacks. Hence, a series of methodologies and defence strategies will be devised that make deep learning systems robust to these ....Deep Learning Attacks and Active Defences: A Cybersecurity Perspective. The belief that deep learning technology is imperative for economic development, military control, and strategic competitiveness has accelerated its development across the globe. However, experience has revealed the disappointing fact that deep learning models are vulnerable to a range of security attacks. Hence, a series of methodologies and defence strategies will be devised that make deep learning systems robust to these attacks. The methodologies require analysing attack lifecycles to identify them in their early stages. With this knowledge, active defence methods and forensic strategies can be developed to ensure efficient defences and prevent further attacks. Moreover, the outputs will be generalisable to most deep learning services.Read moreRead less
Non-urban water governance: rethinking compliance and enforcement. This project aims to critically evaluate the practices and strategies of non-urban water compliance and enforcement in Australia and internationally, to identify and develop innovations for water governance. New law and policy knowledge is expected from its fusion of empirical data and regulatory theory. The project expects to advance applied regulatory theory by identifying improvements in compliance and enforcement to help solv ....Non-urban water governance: rethinking compliance and enforcement. This project aims to critically evaluate the practices and strategies of non-urban water compliance and enforcement in Australia and internationally, to identify and develop innovations for water governance. New law and policy knowledge is expected from its fusion of empirical data and regulatory theory. The project expects to advance applied regulatory theory by identifying improvements in compliance and enforcement to help solve environmental issues. It will also lead to policy reforms for delivering more effective, efficient and politically-acceptable compliance outcomes for non-urban water management that will benefit water regulators and the sustainability and productivity of Australia's agricultural industry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101832
Funder
Australian Research Council
Funding Amount
$425,941.00
Summary
Mechanisms of immune protection for infectious laryngotracheitis virus. This project aims to investigate the mechanisms of immune protection against infectious laryngotracheitis virus. This will be achieved by investigating the role of local and systemic immunity and the immune cells associated with long-term protection against disease. The mechanisms of protection against this virus remain unknown which impairs the development of efficacious vaccines. Expected outcomes of this project are a mor ....Mechanisms of immune protection for infectious laryngotracheitis virus. This project aims to investigate the mechanisms of immune protection against infectious laryngotracheitis virus. This will be achieved by investigating the role of local and systemic immunity and the immune cells associated with long-term protection against disease. The mechanisms of protection against this virus remain unknown which impairs the development of efficacious vaccines. Expected outcomes of this project are a more rational approach to vaccination resulting in the generation of more effective and safer vaccination strategies that should benefit our important poultry industry. Additionally, the new methodologies and knowledge on mucosal immune markers could be utilised for the study of other pathogens.Read moreRead less
Balance and reinforcement: privacy and fairness in high intelligence models. The aim of this project is to develop a series of privacy preservation methods to achieve a new balance between privacy and fairness in highly accurate intelligence models. The main issue in achieving this goal is that high-accuracy intelligence technologies have resulted in significant privacy violations and are very vulnerable to issues of unfairness. This project will analyse the privacy risks associated with intelli ....Balance and reinforcement: privacy and fairness in high intelligence models. The aim of this project is to develop a series of privacy preservation methods to achieve a new balance between privacy and fairness in highly accurate intelligence models. The main issue in achieving this goal is that high-accuracy intelligence technologies have resulted in significant privacy violations and are very vulnerable to issues of unfairness. This project will analyse the privacy risks associated with intelligent systems and devise mechanisms to mutually reinforce both privacy and fairness based on the theoretical foundations laid by our analysis. These outcomes will enable model owners to effectively protect their intellectual property and offer services to users in a private, fair, and accurate manner.Read moreRead less
Reverse chemical proteomics: harnessing yeast display for drug discovery. This project aims to develop a technique that can rapidly identify the cellular protein targets of biologically active natural products. This project expects to provide fundamental biological and chemical insights into Australia's unique biodiversity that will facilitate the development of new therapeutic agents and agrochemicals based on leads provided by Nature. Expected outcomes of this project include an optimised and ....Reverse chemical proteomics: harnessing yeast display for drug discovery. This project aims to develop a technique that can rapidly identify the cellular protein targets of biologically active natural products. This project expects to provide fundamental biological and chemical insights into Australia's unique biodiversity that will facilitate the development of new therapeutic agents and agrochemicals based on leads provided by Nature. Expected outcomes of this project include an optimised and validated platform technology for accelerating drug discovery and development. This should substantially reduce the costs associated with fighting human and animal diseases, leading to improved health, productivity and quality of life.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100025
Funder
Australian Research Council
Funding Amount
$747,126.00
Summary
Using the blackleg fungus as a model for maximising fungicide efficacy. Resistance to chemicals impacts the ability to control many diseases across many crops. This project aims to identify key epidemiological factors contributing to fungicide resistance in an emerging model system, blackleg disease of canola, using innovative approaches. The outcomes of this research will be management strategies for minimising the risk of evolution of fungicide resistance, a key industry need. This will also e ....Using the blackleg fungus as a model for maximising fungicide efficacy. Resistance to chemicals impacts the ability to control many diseases across many crops. This project aims to identify key epidemiological factors contributing to fungicide resistance in an emerging model system, blackleg disease of canola, using innovative approaches. The outcomes of this research will be management strategies for minimising the risk of evolution of fungicide resistance, a key industry need. This will also enhance interdisciplinary collaborations through combining field and molecular research. These management strategies will provide significant economic benefits by ensuring increased canola yields, whilst providing health and environmental benefits through minimisation of unnecessary use of fungicides.Read moreRead less
Novel semio-chemical approach to control the Australian Sheep Blowfly . The Australian Federal Government through the 'Smart Farming' initiative highlights the need for improved multidisciplinary measures in order to remain at the global forefront of the invention and adoption of technology. This multidisciplinary project (entomology, biotechnology, analytical chemistry and genomics) will rapidly inform the management of fly strike on an important Australian resource merino sheep. This will bui ....Novel semio-chemical approach to control the Australian Sheep Blowfly . The Australian Federal Government through the 'Smart Farming' initiative highlights the need for improved multidisciplinary measures in order to remain at the global forefront of the invention and adoption of technology. This multidisciplinary project (entomology, biotechnology, analytical chemistry and genomics) will rapidly inform the management of fly strike on an important Australian resource merino sheep. This will build the key biochemical data in order to develop a novel fly lure technology (at scale) to be used on farm delivering national benefit through improved animal welfare and safety considerations for producers, and will establish the best approach to disseminate this scientific information to stakeholders such as farmers.Read moreRead less