The Putative Drug Metabolising Enzyme SULT4A1 Is A Sulfotransferase Inhibitor
Funder
National Health and Medical Research Council
Funding Amount
$467,851.00
Summary
The sulfotransferase SULT4A1 is a novel protein found predominantly in neurons but its function is unknown. This project will investigate the mechanisms that the body uses to regulate the levels of this protein and how it may interfere with other enzymes essential for metabolising hormones and neurotransmitters.
SULT4A1 is not a sulfotransferase, but a sulfotransferase inhibitor. It forms high affinity heterodimers with other sulfotransferases via a conserved dimerisation site in its carboxyl terminus attenuating catalytic activity. Consequently, it is important for the metabolism of numerous important molecules including estrogens, thyroid hormones, neurotransmitters and many therapeutic agents.
Function Of Sulfotransferase SULT4A1 - Transcriptional And Post-transcriptional Regulation
Funder
National Health and Medical Research Council
Funding Amount
$302,063.00
Summary
Our understanding of how important proteins work is critical to devising modern approaches for disease treatment. This project looks specifically at a protein sulfotransferase 4A1 linked with schizophrenia, and may be involved in other neuronal disorders. The plan is to characterise how the protein functions and what might be the implications of abnormal regulation. Through a series of intricate experiments, the molecular and cellular properties of the protein will be more clearly defined.