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Longitudinal Mechanics Of The Peri-Infarct Zone And Ventricular Tachycardia Inducibility In Patients With Chronic Ischaemic Cardiomyopathy
Funder
National Health and Medical Research Council
Funding Amount
$438,449.00
Summary
Ischaemic heart disease is a major cause of death in developed countries. Sudden cardiac death is precipitated by lethal irregularities in heart rhythm that originate around the scar tissue that forms within the heart after a heart attack. This study�s aim is to investigate the role of new ultrasound technologies in characterising the heart tissue where fatal cardiac arrhythmias arise. We hope that these novel imaging tools will help to identify individuals whose lives may be saved by appropriat ....Ischaemic heart disease is a major cause of death in developed countries. Sudden cardiac death is precipitated by lethal irregularities in heart rhythm that originate around the scar tissue that forms within the heart after a heart attack. This study�s aim is to investigate the role of new ultrasound technologies in characterising the heart tissue where fatal cardiac arrhythmias arise. We hope that these novel imaging tools will help to identify individuals whose lives may be saved by appropriate preventative measures.Read moreRead less
Application Of Genomic Technologies For The Diagnosis And Management Of Genetic Heart Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$438,768.00
Summary
The purpose of this research study is to investigate clinical and genetic factors which may predispose to important cardiac events such as dangerous arrhythmias, heart failure, heart transplantation or sudden cardiac death in patients with genetic heart diseases. It is possible that there are important risk factors or genetic findings which may be identified either through newer technologies which help cardiologists determine which patients and families are most at risk.
Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. A new clinical subgroup of HCM patients who are essentially gene carriers, referred to as "Genotype Positive Phenotype Negative" has arisen as a result of genetic testing in at-risk family relatives. Little is known about the natural history and long-term clinical outcomes of this new clinical subgroup. Understanding these factors is vital to the development of management guidelines that will lead to the best possible ou ....Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. A new clinical subgroup of HCM patients who are essentially gene carriers, referred to as "Genotype Positive Phenotype Negative" has arisen as a result of genetic testing in at-risk family relatives. Little is known about the natural history and long-term clinical outcomes of this new clinical subgroup. Understanding these factors is vital to the development of management guidelines that will lead to the best possible outcome for these patients.Read moreRead less
Electrophysiologic Properties Of The Ventricular Myocardium Promoting Reentry
Funder
National Health and Medical Research Council
Funding Amount
$272,871.00
Summary
Ventricular tachycardia is a dangerous heart rhythm that usually occurs in people with prior heart attacks. These people often have scarring on their heart and the tachycardia occurs due to electrical activity forming a circuit around the scar. This study will examine the factors that cause ventricular tachycardia to begin by looking at the characteristics of the scarring.
Management Of Families With A Genetic Cause Of Sudden Cardiac Death
Funder
National Health and Medical Research Council
Funding Amount
$307,946.00
Summary
Sudden cardiac death (SCD) is a tragic complication of a number of genetic heart diseases, where families have to cope with the grief of losing a family member and the risk to themselves. This research seeks to better understand the psychosocial impact to family members; to determine what access and services families are currently provided with; and to determine the cost-effectiveness of family management strategies. The ultimate goal is that every family will have access to high-quality and cos ....Sudden cardiac death (SCD) is a tragic complication of a number of genetic heart diseases, where families have to cope with the grief of losing a family member and the risk to themselves. This research seeks to better understand the psychosocial impact to family members; to determine what access and services families are currently provided with; and to determine the cost-effectiveness of family management strategies. The ultimate goal is that every family will have access to high-quality and cost-effective management practices.Read moreRead less
Sudden Cardiac Death In Renal Failure And The Use Of Cardiac Defibrillators
Funder
National Health and Medical Research Council
Funding Amount
$404,135.00
Summary
The main cause of death among renal failure patients starting dialysis is from fatal heart rhythms leading to sudden death, preventable with defibrillators. This study will evaluate the effectiveness of the new less invasive defibrillators placed placed just under the skin. It would allow more patients to receive life saving therapy without the vascular complications. It will also improve selection criteria to identify patients who would benefit the most from defibrillators as well as advance ou ....The main cause of death among renal failure patients starting dialysis is from fatal heart rhythms leading to sudden death, preventable with defibrillators. This study will evaluate the effectiveness of the new less invasive defibrillators placed placed just under the skin. It would allow more patients to receive life saving therapy without the vascular complications. It will also improve selection criteria to identify patients who would benefit the most from defibrillators as well as advance our understanding of key predcitors of sudden death.Read moreRead less
Right From The Start: Improving Respiratory Support For Preterm Infants From Their First Breath To Independent Breathing
Funder
National Health and Medical Research Council
Funding Amount
$266,623.00
Summary
My research program with the world leading research team at the Royal Women’s Hospital, Melbourne aims to improve the journey of preterm babies from birth, through the neonatal nursery, to a healthy start at home. Too many preterm babies die or have long term health problems. I will study gentler methods to support breathing from birth, investigate better ways of supporting them until they can breathe independently, and assess how to support more babies to stay in their birth hospitals.
Substrate Mapping And Ablation Of Ventricular Tachycardia
Funder
National Health and Medical Research Council
Funding Amount
$444,129.00
Summary
Sudden death is a tragic occurrence and can afflict Australians of all ages, racial and ethnic backgrounds. This research will aim to understand abnormalities in the heart muscle that cause dangerous heart rhythm abnormalities, which is the most common cause of sudden death. We will study ways to improve the technology of keyhole cardiac procedures so that it can be used to prevent these arrhythmias from occurring in the first place, and in improving the chance of long-term successful cure.
Evaluating Neonatal And Child Health Interventions For Evidence Based Planning And Practice In Low Resourced Countries
Funder
National Health and Medical Research Council
Funding Amount
$410,512.00
Summary
The overall aim is to develop a neonatal and child health research programme responding to the various needs of resource poor country governments and provide an evidence base for public and clinical interventions and health programming. One neonatal study is outlined evaluating alternative phototherapy treatment for neonatal jaundice.