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Transcription-based Identification Of Insulin Resistance Subtypes
Funder
National Health and Medical Research Council
Funding Amount
$341,883.00
Summary
A key feature of type 2 diabetes is the failure of metabolic tissues such as muscle and fat to respond to normal levels of insulin. This 'insulin resistance' is caused by a number of mechanisms. We will use cutting-edge technology to identify small sets of genes that define each variety of insulin resistance. These gene sets will be used to diagnose sub-types of insulin resistance and will facilitate the development of personalised therapies to effectively treat individuals with type 2 diabetes.
Identifying The Critical Components Of Growth Factor-mediated Survival Pathways
Funder
National Health and Medical Research Council
Funding Amount
$589,338.00
Summary
The regulation of cell lifespan (cell survival) is controlled by growth factors and lies at the heart of all biological processes. However, little is known of the molecular switches inside cells that either turn survival on or off. We propose to identify and characterize the molecular switches inside cells that control the balance between cell survival and death. Targeting specific components of these switches may provide new approaches for the treatment of cancer and infectious diseases.
Regulation Of Immune Signalling By Autophagy During Cell Suicide
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Inflammation-driven diseases such as atherosclerosis, cardiovascular disease, arthritis and cancer, are associated with deregulated cell death and are among the fastest growing chronic conditions in Australia. This research will determine the role of a recycles process called autophagy in regulating the immune response to different forms of cell death, thereby identifying new targets amenable to therapeutic intervention of these diseases.
Elucidating The Molecular Regulation Of Gp130 Complex Signalling In Lipid And Glucose Metabolism.
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Overnutrition promotes obesity, which greatly increases the risk of type 2 diabetes and cardiovascular disease. We have provided evidence that activation of gp130 signalling may enhance insulin action and fatty acid oxidation in metabolically active tissues. My research proposal aims to elucidate the molecular regulation of gp130 complex signalling in lipid and glucose metabolism in important metabolic tissues.
Identification Of Key Enzymes Required For Efficient Post-translational Modification And Multimerisation Of Adiponectin
Funder
National Health and Medical Research Council
Funding Amount
$92,364.00
Summary
Obesity is a major national and global health issue, with 62% of adult Australians being overweight/obese, associated with a number of diseases such as type 2 diabetes and cardiovascular disease. Fat tissue secretes hormones and dysregulation of these hormones contributes to the development of obesity-associated disease. This project aims to define processes governing the secretion of one key hormone and ultimately to identify targets for the treatment of obesity-associated complications.
Akt Kinase Signalling, Regulated Vesicular Transport And Lipid Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$337,850.00
Summary
How do metabolic cues tell cancer cells to make more membranes, or fat cells to make more fat? These are some of the questions that underpin this project, which explores the link between cell signalling, protein trafficking and fat metabolism. Specifically, we aim to define the role of an important signalling molecule (Akt) in intracellular transport and activation of a key integrator of fat metabolism (SREBP). This work will have wide-ranging implications for human health and disease.
Manipulation Of Energy Metabolism To Control Lipid Accumulation And Insulin Action.
Funder
National Health and Medical Research Council
Funding Amount
$804,106.00
Summary
I am a metabolic biochemist investigating how overconsumption of calories, particularly fat, results in dysfunctional energy metabolism and increased the risk of type 2 diabetes. I examine changes in the daily rhythms of energy intake, energy utilisation and energy storage in different tissues of dietary and genetically modified animals to pinpoint novel ways of reducing fat accumulation and reducing the risk of type 2 diabetes.
Metabolic Stress Sensing By AMPK: Implications For Energy Balance And Isoform-targetting Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$632,188.00
Summary
Metabolic diseases such as obesity, type 2 diabetes and cardiovascular disease impose enormous medical and economic burdens on Western societies. Our research is focussed on the enzyme AMP-activated protein kinase (AMPK) which acts as the fuel gauge of the cell and is a promising drug target for combating metabolic diseases. Our discoveries provide critical insight on how AMPK is switched on by both energy demand and drugs, and will greatly assist development of AMPK-targetted therapeutics.