Alternate Splicing Of Tryptase Genes Regulates Their Specificity
Funder
National Health and Medical Research Council
Funding Amount
$294,250.00
Summary
Tryptases are enzymes implicated in inflammatory disorders including arthritis, inflammatory bowel disease (IBD) and asthma. Specific tryptase inhibitors are effective in treating these diseases. We have discovered that each human tryptase gene is processed into two different protein products via a mechanism called alternate splicing. We will investigate the structure and function of these.