Reducing The Burden Of Alcohol And Other Drug Use In Australia
Funder
National Health and Medical Research Council
Funding Amount
$250,805.00
Summary
Innovative research undertaken during the Fellowship program will provide new evidence of how best to respond to alcohol and other drug use. Partnerships with policymakers will ensure this evidence underpins Australian alcohol and other drug policy.
A Randomised Controlled Trial Of N-acetylcysteine For The Treatment Of Alcohol Use Disorder
Funder
National Health and Medical Research Council
Funding Amount
$1,294,923.00
Summary
We urgently require new treatment strategies. Alcohol misuse is a leading cause of preventable death yet treatment options are limited. We will undertake the first human trial of N-acetylcysteine (NAC) for the management of alcohol use disorder (NAC-AUD). The NAC-AUD project will evaluate the efficacy and cost-efficacy of NAC to reduce alcohol consumption. The results will generate high level clinical evidence for a safe new treatment for a common life threatening disease.
Defining The Clinical Role Of Topiramate In The Treatment Of Alcohol Dependence In Australia
Funder
National Health and Medical Research Council
Funding Amount
$718,836.00
Summary
We urgently require new strategies for the treatment of alcohol dependence. The effectiveness of currently approved alcohol medications is limited. Emerging data suggests that topiramate has robust effectiveness and that better medicine selection is possible for patients based on their genotype. We propose to conduct a double-blind randomised controlled trial to examine the clinical and cost effectiveness of topiramate using a genetically based personalised approach.
Addressing The Hidden Epidemic Of Child And Adolescent Trauma
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
It is critical to address the hidden epidemic of child and adolescent trauma to improve the health and welfare of Australians. This research will not only enhance our understanding of the prevalence and impact of early trauma among Australians, but will also provide rigorous evidence for effective psychological interventions for the millions impacted by this significant and pervasive public health issue.
Determining The Impacts Of COVID-19 Restrictions On People Who Use Drugs
Funder
National Health and Medical Research Council
Funding Amount
$429,228.00
Summary
COVID-19 has resulted in unparalleled government interventions to close borders and restrict social interactions which have major implications for illicit drug supply, procurement and use practices, as well as responses. People who use drugs will be profoundly impacted by COVID-19 and so our study will leverage existing data collections to compare drug use practices and consequences before, during and after the COVID-19 interventions to determine COVID-19 impacts on people who use drugs.
Preventing Anxiety, Depression And Substance Use In Adolescents.
Funder
National Health and Medical Research Council
Funding Amount
$1,709,988.00
Summary
Anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. Yet we have few models of well-implemented prevention programs for these common disorders. The current proposal addresses this gap by evaluating an innovative internet-based approach to preventing mental health and substance use problems in Australian adolescents.
Reducing The Health, Social And Economic Burden Of Injecting Drug Use In Australia
Funder
National Health and Medical Research Council
Funding Amount
$2,606,037.00
Summary
Injecting drug use (IDU) is a disproportionately large source of health and social harm. This CRE unites Australia’s leading scientists in the IDU field – researchers working on blood-borne virus epidemiology and treatment, overdose prevention, justice health and psychiatric health - and experts from key non-government organisations. The CRE will develop new ways to improve the health of injecting drug users, and reduce the health and social burden of IDU to the Australian community.
The Role Of Preconception And Perinatal Substance Use And Misuse In Childhood Social, Emotional And Behavioural Problems
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
This project will use perinatal and preconception data from three long-running Australian studies that have tracked the health and wellbeing of several thousand participants prior to parenthood. The aim is to understand how parental histories of substance use, and patterns of use during pregnancy, and in early life, shape offspring social, emotional and behavioural outcomes across childhood. Results will inform new approaches to preventing substance-related harms within and across generations.
Investigating The Relationships Between Alcohol And Other Drug Use, Mental Health, Early-life Factors And Life-course Outcomes: Integrative Analyses Of Data From Four Australasian Cohort Studies
Funder
National Health and Medical Research Council
Funding Amount
$448,198.00
Summary
The current study will use a highly innovative approach to pool data from four large and long-running Australasian cohort studies to better understand the developmental precursors and psychosocial consequences of teen drinking behaviours. Findings will provide dramatically improved knowledge of the developmental pathways to teen and young adult drinking and a clearer picture of the total burden of disease attributable to alcohol in an Australasian setting.