When is extinction not extinction? Disorders of fear and anxiety are widespread and impose significant burdens on individual sufferers and their families. This projects studies new ways of augmenting loss of fear and will identify the important behavioural mechanisms as well as critical brain pathways for this fear loss.
Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and w ....Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and witness memory accuracy. Crucially, crimes are frequently distressing; therefore the interaction between intoxication and stress urgently requires exploration. This project will significantly advance our understanding of key mechanisms behind drug effects on memory, and support fairer judicial outcomes for all. Read moreRead less
The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two insta ....The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two instances of this learning: extinction and latent inhibition. Using a new procedure that avoids earlier confounds, we will describe and compare the processes underlying extinction and latent inhibition. This research will represent a major breakthrough in our understanding about fundamental processes in learning.Read moreRead less
Uncertainty and response control in the prefrontal cortex. This project will identify how complex behaviours come to be performed habitually. It is proposed that statistical certainty in the learning environment is a key determinant of automatic behaviour, that detection of uncertainty can restore voluntary control of behaviour and that this is an important function of the prefrontal cortex of the brain.
Models of adolescent drug use and its consequences. Recent concerns surround the impact of drug abuse - particularly binge drinking, inhalant abuse and cannabis use - on the mental health of adolescents. Early drug use is associated with mental health problems although the mechanisms involved are not well characterised. The present proposal aims to use animal models to characterise substance abuse that occurs during the adolescent period and to investigate its effects on brain and behaviour. Inc ....Models of adolescent drug use and its consequences. Recent concerns surround the impact of drug abuse - particularly binge drinking, inhalant abuse and cannabis use - on the mental health of adolescents. Early drug use is associated with mental health problems although the mechanisms involved are not well characterised. The present proposal aims to use animal models to characterise substance abuse that occurs during the adolescent period and to investigate its effects on brain and behaviour. Increasing our knowledge of the causes and consequences of adolescent drug abuse will improve Australia's ability to confront this problem and to develop early interventions and treatments that minimise associated harms.Read moreRead less
Can parents teach their children to drink alcohol responsibly? Or, is one drop a drop too many? Parents typically supply alcohol to their children believing it is the best way to teach responsible drinking. Whether parents should provide alcohol is controversial and the evidence to inform this decision is unclear. This research will provide an in-depth understanding of the consequences of parents providing alcohol to their children and when, where and how this can be done to minimise harm. This ....Can parents teach their children to drink alcohol responsibly? Or, is one drop a drop too many? Parents typically supply alcohol to their children believing it is the best way to teach responsible drinking. Whether parents should provide alcohol is controversial and the evidence to inform this decision is unclear. This research will provide an in-depth understanding of the consequences of parents providing alcohol to their children and when, where and how this can be done to minimise harm. This is a national priority as alcohol abuse is a leading cause of injury and death among young Australians and developing the knowledge for preventive health care is essential. This research will provide parents with the information they need to give their children a healthier start to life.Read moreRead less
Age-dependent effects of cannabinoids on emotion, cognition and vulnerablity to addiction. Cannabis is the most widely used illicit drug in Australia so understanding the effects of this drug is of great importance. There is little of no basic research on cannabis currently occurring in Australia. Yet such research is critical in resolving the ambiguities and difficulties inherent in our understanding of the drug. The importance of increasing our understanding of the long-term effects of the dr ....Age-dependent effects of cannabinoids on emotion, cognition and vulnerablity to addiction. Cannabis is the most widely used illicit drug in Australia so understanding the effects of this drug is of great importance. There is little of no basic research on cannabis currently occurring in Australia. Yet such research is critical in resolving the ambiguities and difficulties inherent in our understanding of the drug. The importance of increasing our understanding of the long-term effects of the drug on young developing brains is particularly evident. The information gained in the current project will serve to inform medical and scientific communities, government policy makers, as well as the broader Australian community. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100509
Funder
Australian Research Council
Funding Amount
$388,000.00
Summary
Molecular mechanisms causing relapse. This project aims to identify the neural connectivity and molecular profile of ventral pallidal neurons in the brain that control drug and alcohol addiction, relapsing disorders where users lose the ability to inhibit drug seeking behaviour. This project integrates neurobiological and psychological attributes of relapse. The anticipated outcomes provide insights about molecular mechanisms causing relapse, and expand knowledge of brain mechanisms that contrib ....Molecular mechanisms causing relapse. This project aims to identify the neural connectivity and molecular profile of ventral pallidal neurons in the brain that control drug and alcohol addiction, relapsing disorders where users lose the ability to inhibit drug seeking behaviour. This project integrates neurobiological and psychological attributes of relapse. The anticipated outcomes provide insights about molecular mechanisms causing relapse, and expand knowledge of brain mechanisms that contribute to relapsing disorders such as drug addiction and obesity. The findings from this project could be used to reduce relapse, and hence reduce the burden of alcohol related problems on health, the community and the Australian economy.Read moreRead less
Non-medical use of prescription stimulants by Australian university students: attitudes, prevalence of, and motivations for use. This study will provide a comprehensive understanding of student non-medical use of prescription stimulants. The findings will inform initiatives to prevent the abuse and misuse of pharmaceuticals, protect health and reduce the cost associated with inappropriate use of medicines.
Youth off the streets (YOTS): Rehabilitating at-risk youth and young offenders through responsive service learning programs. Young people involved in substance abuse and delinquency are a major economic and social cost to Australia. Although numerous crime prevention strategies have been developed for working with at-risk, homeless, substance abusing and delinquent young people, few have been adequately evaluated and outcomes are poor. Almost none reflect contemporary knowledge in theories of a ....Youth off the streets (YOTS): Rehabilitating at-risk youth and young offenders through responsive service learning programs. Young people involved in substance abuse and delinquency are a major economic and social cost to Australia. Although numerous crime prevention strategies have been developed for working with at-risk, homeless, substance abusing and delinquent young people, few have been adequately evaluated and outcomes are poor. Almost none reflect contemporary knowledge in theories of adolescent development. This research will develop an innovative intervention based on Service Learning relevant to other diversion programs within Juvenile Justice and an industry model for long-term sustainable program evaluation. We will also develop an intervention model relevant to other organisations with similar aims and budgetary constraints.Read moreRead less