The influence of parental alcohol expectancies on offsprings' alcohol expectancies and drinking: A longitudinal study. It has been shown that potentially modifiable alcohol related cognitions, such as alcohol expectancies (AE)and drinking refusal self-efficacy (DRSE) are formed in childhood are related to drinking in adolescents and adults. The question of how these beliefs are formed is still unanswered. This longitudinal study examines the influences of parental alcohol-related beliefs and ....The influence of parental alcohol expectancies on offsprings' alcohol expectancies and drinking: A longitudinal study. It has been shown that potentially modifiable alcohol related cognitions, such as alcohol expectancies (AE)and drinking refusal self-efficacy (DRSE) are formed in childhood are related to drinking in adolescents and adults. The question of how these beliefs are formed is still unanswered. This longitudinal study examines the influences of parental alcohol-related beliefs and drinking, on children's alcohol-related beliefs and drinking behaviour. Positive results of this study will improve primary prevention by identifying and changing modifiable variables for populations potentially at-risk of developing later alcohol-related. It will also help to reduce cost and suffering of a major problem in Ausstralia.
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The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations ....The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations will predict the development of alcohol/tobacco use and misuse, after accounting for viable alternative explanations of the association. Understanding the role that memory associations have in the development of alcohol/tobacco use should inform prevention programs for at-risk adolescents.Read moreRead less
Alcohol advertising to women in Australia. Young Australian women are drinking more and drinking in more harmful ways. At the same time, advertisers are using new media (such as social network sites) and messages (such as empowerment) to advertise alcohol to women. Using a combination of quantitative, qualitative and experimental methods, this project will explore how alcohol is advertised to Australian women (in both traditional and new media), and how this influences their alcohol-related atti ....Alcohol advertising to women in Australia. Young Australian women are drinking more and drinking in more harmful ways. At the same time, advertisers are using new media (such as social network sites) and messages (such as empowerment) to advertise alcohol to women. Using a combination of quantitative, qualitative and experimental methods, this project will explore how alcohol is advertised to Australian women (in both traditional and new media), and how this influences their alcohol-related attitudes and behaviours. Answering these questions is expected to enable development of recommendations for regulation of alcohol advertising messages, creation of counter-advertising/social marketing messages, and production of alcohol advertising literacy programs for secondary and tertiary students.Read moreRead less
Drosophila Quantitative Genomics. This research proposal will be a key element in the emerging program in evolutionary and ecological functional genomics at the University of Queensland. Our studies utilize modern genomics approaches to address diverse national priorities from conservation of biological resources in the face of climate change, to understanding how genetic history contributes to drug susceptibility. The research will contribute to the intellectual foundation upon which rigorous ....Drosophila Quantitative Genomics. This research proposal will be a key element in the emerging program in evolutionary and ecological functional genomics at the University of Queensland. Our studies utilize modern genomics approaches to address diverse national priorities from conservation of biological resources in the face of climate change, to understanding how genetic history contributes to drug susceptibility. The research will contribute to the intellectual foundation upon which rigorous environmental and biomedical research is built. Social impact will be seen in the training of a new generation of integrative genome biologists, and the shaping of attitudes toward the role of genetics in human biology.Read moreRead less
Addiction, moral identity and moral agency: Integrating theoretical and empirical approaches. By clarifying and evaluating scientific claims about the moral impacts of addiction on the judgment and practices of drug addicted persons and by investigating the perspectives of users and treatment professionals, our project will contribute to the development of ethical and effective public policy, treatment and education programs in the addictions area, thus helping to address the causes and reduce t ....Addiction, moral identity and moral agency: Integrating theoretical and empirical approaches. By clarifying and evaluating scientific claims about the moral impacts of addiction on the judgment and practices of drug addicted persons and by investigating the perspectives of users and treatment professionals, our project will contribute to the development of ethical and effective public policy, treatment and education programs in the addictions area, thus helping to address the causes and reduce the impact of biological, social and environmental factors which diminish life potential in drug addicted persons. The innovative features of this project will enhance Australia's international reputation in bioethics and moral psychology, extend the reach of experimental philosophy, and facilitate future interdisciplinary work.Read moreRead less
A community-based approach to the problem of underage drinking. This project will aim to reduce the frequency and amount of alcohol consumption, and alcohol-related harms, among young people aged 12-17 years by addressing social norms regarding underage alcohol consumption. Using a multi-component intervention it will engage the Illawarra community in strategies to encourage and empower young people not to drink.
Determinants of Expression, Assembly and Function of the Noradrenaline Transporter. The noradrenaline transporter protein that is the focus of this project is important for mental health because it belongs to the family of proteins where psychostimulants, such as cocaine, and drugs used in the treatment of depression act. The project will lead to exciting advances in our understanding of how the structure of this protein controls its functions, and potentially to the design of better antidepress ....Determinants of Expression, Assembly and Function of the Noradrenaline Transporter. The noradrenaline transporter protein that is the focus of this project is important for mental health because it belongs to the family of proteins where psychostimulants, such as cocaine, and drugs used in the treatment of depression act. The project will lead to exciting advances in our understanding of how the structure of this protein controls its functions, and potentially to the design of better antidepressant drugs and to the design of drugs to prevent the effects of cocaine.Read moreRead less
Into the thirties: Persistence and social consequences of risky drinking. The aim of this project is to investigate the social contexts, roles and consequences of problematic alcohol use in adults aged 30, using long term longitudinal resources able to observe the development and corollary of alcohol use over time. It is posited that such drinkers entering their third decade of life persist in levels of problematic alcohol use typically associated with younger ages and that this leads to social ....Into the thirties: Persistence and social consequences of risky drinking. The aim of this project is to investigate the social contexts, roles and consequences of problematic alcohol use in adults aged 30, using long term longitudinal resources able to observe the development and corollary of alcohol use over time. It is posited that such drinkers entering their third decade of life persist in levels of problematic alcohol use typically associated with younger ages and that this leads to social consequences, such as gender specific risks, relationship conflicts and more severe long term effects. Outcomes from this project are expected to inform the generation of relevant prevention and intervention strategies aimed to address problem drinking in adult Australians.Read moreRead less
Dynamic social systems and adolescent alcohol/tobacco use: A new cusp catastrophe model. This research will substantially improve our understanding of the development of adolescent high-risk behaviours. It will directly inform multimodal prevention strategies by demonstrating how substance use, peer factors, and parent relationships unfold over time. This is much needed because most prevention strategies are too simplistic to address complex precursors to alcohol/tobacco use. The research wil ....Dynamic social systems and adolescent alcohol/tobacco use: A new cusp catastrophe model. This research will substantially improve our understanding of the development of adolescent high-risk behaviours. It will directly inform multimodal prevention strategies by demonstrating how substance use, peer factors, and parent relationships unfold over time. This is much needed because most prevention strategies are too simplistic to address complex precursors to alcohol/tobacco use. The research will benefit health researchers in and beyond Australia who seek to understand behaviours that do not adhere to conventional assumptions. Collaboration with researchers from leading national and international centres will enhance Australia's research reputation and will attract postgraduates and researchers to Australia.Read moreRead less
Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is ....Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is focused on studying structural features of a range of peptides and their contributions to both activity and to resistance against degradation, with the aim to develop stabilised bioactive peptide sequences for in vivo applications, allowing the full potential of peptides as drugs to be realised.Read moreRead less