Genetic architecture of species divergence and hybridisation in eucalypts. Eucalypts are an icon of Australia and are of great economic and ecological significance to the nation. They are the most widely planted hardwood trees in the world, but Australia is the centre of origin of most species and the custodian of this important native bioresource. Understanding the evolutionary processes that shape diversity in this internationally significant genus is important for its long-term management a ....Genetic architecture of species divergence and hybridisation in eucalypts. Eucalypts are an icon of Australia and are of great economic and ecological significance to the nation. They are the most widely planted hardwood trees in the world, but Australia is the centre of origin of most species and the custodian of this important native bioresource. Understanding the evolutionary processes that shape diversity in this internationally significant genus is important for its long-term management and conservation. This project links to large international initiatives currently underway for high-density mapping and sequencing of the eucalypt genome, to enhance the flow of information gained back to Australia for scientific, economic and environmental benefit.Read moreRead less
Rapid method development in pharmaceutical analysis using quality-by-design principles. Chemical analysis using separation methods underpins all stages of drug design and analysis. This project will generate new approaches to greatly reduce the time taken to develop a new method of analysis. This will be achieved through development of new computerised techniques for rapid screening, selection and optimisation of analytical methods.
Advanced matrix-analytic methods with applications. Over the last twenty-five years, matrix-analytic methods have proved to be very successful in formulating and analysing certain classes of stochastic models. Motivated by applications, this project will investigate more advanced matrix-analytic methods than have hitherto been studied.
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Remotely sensed forest water use in space and time. Remotely sensed forest water use in space and time. This project aims to develop and apply new methods to scale forest water use from plot to catchment-level, using relationships between plot-level annual evapotranspiration and biophysical and biochemical properties of stands detectable by unmanned aircraft systems and other remote sensing platforms. Australia's water security depends on understanding how changes in forests from disturbance and ....Remotely sensed forest water use in space and time. Remotely sensed forest water use in space and time. This project aims to develop and apply new methods to scale forest water use from plot to catchment-level, using relationships between plot-level annual evapotranspiration and biophysical and biochemical properties of stands detectable by unmanned aircraft systems and other remote sensing platforms. Australia's water security depends on understanding how changes in forests from disturbance and climate change influence catchment water yields. This project will estimate water yields over time and space in ungauged catchments with disturbed eucalypt forests. This research is expected to enable more effective risk mitigation and planning for augmentations; improved fire management strategies; and better water management of the Murray Darling Basin.Read moreRead less
Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
Change Detection in Causal Relationships and Measurement of Systemic Risk. Empirical measures of interconnectedness between financial institutions based on tests of Granger causality are currently used in detecting systemic risk. However, researchers need to define periods of calm and stress exogenously in order to implement these tests appropriately. This project aims to develop a new procedure to identify changes in causal relationships and the timing of these changes. The new approach has the ....Change Detection in Causal Relationships and Measurement of Systemic Risk. Empirical measures of interconnectedness between financial institutions based on tests of Granger causality are currently used in detecting systemic risk. However, researchers need to define periods of calm and stress exogenously in order to implement these tests appropriately. This project aims to develop a new procedure to identify changes in causal relationships and the timing of these changes. The new approach has the potential to be a significant improvement in the real-time identification of emerging turmoil in financial markets and provide an improved method for the detection of systemic risk. The new test procedure will be implemented using data for financial and non-financial institutions across Europe, the US and Australia.Read moreRead less
Tectonic geography of the world's oldest petroleum play, the McArthur Basin. This projects aims to develop a 4D tectonic geography framework to support the effective exploration of the McArthur Basin. This project will construct this by a) investigating the evolving tectonic setting, b) examining intra-basin correlations and trace the source to sink sediment provenance, c) unraveling the depositional geography using novel isotopic proxies, and, d) constructing the subsequent thermal history of ....Tectonic geography of the world's oldest petroleum play, the McArthur Basin. This projects aims to develop a 4D tectonic geography framework to support the effective exploration of the McArthur Basin. This project will construct this by a) investigating the evolving tectonic setting, b) examining intra-basin correlations and trace the source to sink sediment provenance, c) unraveling the depositional geography using novel isotopic proxies, and, d) constructing the subsequent thermal history of the basin. The techniques developed through this project will de-risk the exploration for petroleum in this basin, and be applicable in opening up Proterozoic petroleum elsewhere in Australia and internationally.Read moreRead less
Hybrid Remote Area Power Systems with Hydrogen Energy Storage for Isolated and Regional Communities. The distances and difficulties of transporting diesel to remote areas substantially add to the cost of electricity - making it many times the cost of supplies available from the grid. Consistency of electricity supply is dependent on reliable transport access and substantial storage for fuel on site. This project will reduce emissions in energy generation and provide the opportunity for mainly ....Hybrid Remote Area Power Systems with Hydrogen Energy Storage for Isolated and Regional Communities. The distances and difficulties of transporting diesel to remote areas substantially add to the cost of electricity - making it many times the cost of supplies available from the grid. Consistency of electricity supply is dependent on reliable transport access and substantial storage for fuel on site. This project will reduce emissions in energy generation and provide the opportunity for mainly renewable, high-quality electricity supplies at reduced cost for remote and isolated communities. This will make communities more self-sufficient, enhance the quality of life and provide opportunities for initiatives, including economic and employment generating activities, to benefit the communities.Read moreRead less
Optimising Control of Hydroelectric Turbines Subject to Basslink Instability. With the introduction of Basslink, an underwater DC power cable across the Bass Strait, Tasmania will be connected to the national Electricity Market. Basslink will also provide an opportunity to utilise the significant water energy potential found throughout Tasmania. This project will examine the impact and disturbances due to the connection of Basslink with Tasmanian hydro power systems and develop control strategi ....Optimising Control of Hydroelectric Turbines Subject to Basslink Instability. With the introduction of Basslink, an underwater DC power cable across the Bass Strait, Tasmania will be connected to the national Electricity Market. Basslink will also provide an opportunity to utilise the significant water energy potential found throughout Tasmania. This project will examine the impact and disturbances due to the connection of Basslink with Tasmanian hydro power systems and develop control strategies for effective operation and control of hydro turbines with Basslink. Particular attention will be paid to the quality and reliability of electricity supply in Tasmania.Read moreRead less