ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Sex determination in dragons: Genetics, epigenetics and environment. This project aims to discover the master sex-determining gene in a reptile, how that gene is differentially regulated in males and females and by temperature, and to identify evolutionary drivers of transitions between genetic and environmental sex determination. In many reptiles, like mammals, chromosomes determine sex. In others, the temperature at which their eggs are incubated determines sex. This project will study how tem ....Sex determination in dragons: Genetics, epigenetics and environment. This project aims to discover the master sex-determining gene in a reptile, how that gene is differentially regulated in males and females and by temperature, and to identify evolutionary drivers of transitions between genetic and environmental sex determination. In many reptiles, like mammals, chromosomes determine sex. In others, the temperature at which their eggs are incubated determines sex. This project will study how temperature reverses chromosomal sex determination in dragon lizards. This could show how climatic extremes affect the biology of climate sensitive reptiles, and understand their vulnerability to climate change.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0667981
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Kangaroo Genome Resource Management Facility. Increasingly, large Australian multicentre research programs in biological and medical sciences have a genomics component that involves integration of biological information with sequencing data. The success of these research programs depends on rapid internet access to the research information by all participating scientists. The universal design of the proposed information management system means that it can be easily adapted to support a broad ran ....Kangaroo Genome Resource Management Facility. Increasingly, large Australian multicentre research programs in biological and medical sciences have a genomics component that involves integration of biological information with sequencing data. The success of these research programs depends on rapid internet access to the research information by all participating scientists. The universal design of the proposed information management system means that it can be easily adapted to support a broad range of research programs. The development of this software program therefore has the potential to benefit research scientists, academics and students in many related fields, as well as the broader community, through enhancing research outcomes.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Analysing gender in research and policy on alcohol-related violence. This project aims to provide insights into gendered aspects of research and policy on alcohol-related violence among young people. It will produce knowledge through a comparative approach encompassing key alcohol policy contexts in Australia, Canada and Sweden. Project outcomes will improve the capacity of health and policy practitioners to understand the relationships between gender, alcohol and violence; reconceptualise resp ....Analysing gender in research and policy on alcohol-related violence. This project aims to provide insights into gendered aspects of research and policy on alcohol-related violence among young people. It will produce knowledge through a comparative approach encompassing key alcohol policy contexts in Australia, Canada and Sweden. Project outcomes will improve the capacity of health and policy practitioners to understand the relationships between gender, alcohol and violence; reconceptualise responses to alcohol-related problems; inform the development of future alcohol research and policy; increase the capacity to respond more effectively to alcohol use; and reduce alcohol-related harm.Read moreRead less
Alcohol’s harm to others: patterns, costs, disparities and precipitants. This project aims to generate understanding of the magnitude, character, economic burden, disparities and precipitants of occurrence of alcohol’s harm to others across Australia, using a national survey, crime, community services and health data and qualitative interviews. The project outcome will be a robust current evidence base for our partners, government and Australian society to underpin advocacy, policy and planning, ....Alcohol’s harm to others: patterns, costs, disparities and precipitants. This project aims to generate understanding of the magnitude, character, economic burden, disparities and precipitants of occurrence of alcohol’s harm to others across Australia, using a national survey, crime, community services and health data and qualitative interviews. The project outcome will be a robust current evidence base for our partners, government and Australian society to underpin advocacy, policy and planning, aimed at reducing alcohol-related harm and suffering.Read moreRead less
Exploring Wellbeing Outcomes in the Aquatic and Recreation Industry. This project aims to investigate the impact on individual wellbeing through use of public aquatic and recreation centres in Australia. Through the use of mixed methods across multiple locations, the project expects to generate new knowledge on the effect on users of different management and service models for the provision of aquatic and recreational infrastructure. Expected outcomes include a quantifiable measure of social and ....Exploring Wellbeing Outcomes in the Aquatic and Recreation Industry. This project aims to investigate the impact on individual wellbeing through use of public aquatic and recreation centres in Australia. Through the use of mixed methods across multiple locations, the project expects to generate new knowledge on the effect on users of different management and service models for the provision of aquatic and recreational infrastructure. Expected outcomes include a quantifiable measure of social and emotional wellbeing that can be utilised by centre management and government. This will help assessment of best practice for maximising community wellbeing, and can guide investment decisions by state and local government.Read moreRead less
Belonging and sexual citizenship among gender and sexual minority youth. In the context of well-documented threats to the mental health and well-being of minority young people, this project will examine the experiences of two different generations of gender and sexual minority youth growing up in Australia, and the sources of support they have found most useful. Innovative contextual analysis will involve documentary and archival research alongside individual and group interviews. Through a focu ....Belonging and sexual citizenship among gender and sexual minority youth. In the context of well-documented threats to the mental health and well-being of minority young people, this project will examine the experiences of two different generations of gender and sexual minority youth growing up in Australia, and the sources of support they have found most useful. Innovative contextual analysis will involve documentary and archival research alongside individual and group interviews. Through a focus on the promotion of well-being and participatory citizenship in a rapidly changing social world, the findings aim to contribute new theory concerning transitions from youth to adulthood, improved methodology for the study of marginal and sometimes hard-to-reach populations, and better quality policy and practice.Read moreRead less