Pharmacogenetic And Structural Investigation Of The Omega Class Glutathione Transferases
Funder
National Health and Medical Research Council
Funding Amount
$490,020.00
Summary
Members of the family of enzymes known as glutathione transferases are known to be responsible for the metabolism and detoxification of a wide range of compounds including therapeutic drugs and cancer causing chemicals. Genetic variation in an individual's compliment of glutathione transferases can alter their response to drug treatment or their susceptibility to cancer. The Omega class of glutathione transferases are important because they are involved in the metabolism of arsenic and because t ....Members of the family of enzymes known as glutathione transferases are known to be responsible for the metabolism and detoxification of a wide range of compounds including therapeutic drugs and cancer causing chemicals. Genetic variation in an individual's compliment of glutathione transferases can alter their response to drug treatment or their susceptibility to cancer. The Omega class of glutathione transferases are important because they are involved in the metabolism of arsenic and because they have been shown to influence the age-at-onset of both Alzheimer s and Parkinson s diseases. The present studies will investigate the structure and function of different Omega class glutathione transferases and determine how they interact with arsenic based drugs. These studies will attempt to determine why the toxicity of arsenic varies between individuals and aims to prevent adverse reactions to arsenic containing drugs used in cancer therapy. These studies will also investigate the mechanism by which the inheritance of certain forms of Omega class glutathione transferase can affect the age at-onset of Alzheimer s disease and Parkinson s disease. The understanding of this mechanism may provide the basis for a therapy that could delay or prevent the onset of these common diseases.Read moreRead less
Trade unionism and trade union aid in Indonesia, Malaysia and Timor- Leste. This project will trace flows of trade union aid to Indonesia, Malaysia and Timor Leste and analyses its impact on local labour movements. It will provide valuable information about the trade unions and industrial relations systems of each country, and new insights into the international politics and practice of the international labour movement.
Women, politics and democracy: political labour in India and Indonesia . This project aims to advance understandings of Asia's two largest democracies through an examination of the pathways and dead-ends to political power for women in India and Indonesia. Research of women's everyday political labour will examine their contributions to generating different forms of power, and their adverse incorporation into political structures. The comparative ethnographic approach will lead to the developme ....Women, politics and democracy: political labour in India and Indonesia . This project aims to advance understandings of Asia's two largest democracies through an examination of the pathways and dead-ends to political power for women in India and Indonesia. Research of women's everyday political labour will examine their contributions to generating different forms of power, and their adverse incorporation into political structures. The comparative ethnographic approach will lead to the development of analytical and conceptual tools to understand democracy across different socio-historical contexts. The project aims to produce policy and practice relevant knowledge to increase the meaningful participation of women in politics in India and Indonesia, with comparative lessons for other countries Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100958
Funder
Australian Research Council
Funding Amount
$374,702.00
Summary
Crime and change in urban communities: a longitudinal study of violence, community networks and the collective capacity for action. This project examines the community contexts that influence the spatial variation of violence over time. It will identify the structural conditions of the community that cause crime and the mediating effects of dynamic community processes. The results will identify the critical factors that lead to the persistence or cessation of violence.
Discovery Early Career Researcher Award - Grant ID: DE130100468
Funder
Australian Research Council
Funding Amount
$365,144.00
Summary
Decentralisation in India and Indonesia: how non-government organisations affect citizens' encounters and experiences of local level governance. This project critically examines how local non-government organisations affect decentralisation in India and Indonesia. It offers new understandings of the potential for development agencies to transform the meanings, practices and identities that shape how citizens experience local governance.
Discovery Early Career Researcher Award - Grant ID: DE170100570
Funder
Australian Research Council
Funding Amount
$358,715.00
Summary
Evolving social, moral and economic values of blood in China. This project aims to explore the changing economic, social, moral and political meanings of blood in 20th and 21st century China, particularly the relationship between blood economies and multiple inequalities. The project will research the selling, buying and donation of blood in Chinese history, challenge contemporary understandings of resistance to blood-donation, and suggest solutions to contemporary problems in China’s blood sect ....Evolving social, moral and economic values of blood in China. This project aims to explore the changing economic, social, moral and political meanings of blood in 20th and 21st century China, particularly the relationship between blood economies and multiple inequalities. The project will research the selling, buying and donation of blood in Chinese history, challenge contemporary understandings of resistance to blood-donation, and suggest solutions to contemporary problems in China’s blood sector. The results are expected to contribute to welfare, blood sector and policy reform and to concerns about health, inequality and security in China in an interconnected world.Read moreRead less
The Just-in-Time Self: Young Men, Skill and Narratives of Aspiration in the New Economy. Employers and policy-makers frequently lament the 'skills gap': the shortage of workers with the skills required to perform the available jobs. This cannot be solved simply by funding more vocational training courses. To improve participation in training it is important to understand how vocational aspirations are formed. This research will demonstrate how, through their involvement in collective creative pr ....The Just-in-Time Self: Young Men, Skill and Narratives of Aspiration in the New Economy. Employers and policy-makers frequently lament the 'skills gap': the shortage of workers with the skills required to perform the available jobs. This cannot be solved simply by funding more vocational training courses. To improve participation in training it is important to understand how vocational aspirations are formed. This research will demonstrate how, through their involvement in collective creative projects, young men from poor backgrounds, develop skills and inclinations that might move them beyond the traditional model of manual labour to develop the flexibility required of workers in the 'new economy'.Read moreRead less
The time of our lives: Time equity and the balancing of market and non-market production in the modern Australian population. This project will yield new information relevant to the national social inclusion agenda and the research priority goal of understanding and strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, fulfilling lives. Through a multilayered analysis of gender, class, life course stage, time allocation and the connection ....The time of our lives: Time equity and the balancing of market and non-market production in the modern Australian population. This project will yield new information relevant to the national social inclusion agenda and the research priority goal of understanding and strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, fulfilling lives. Through a multilayered analysis of gender, class, life course stage, time allocation and the connections between them, it will demonstrate links between various forms of social and economic participation and identify how they could be distributed more evenly. This knowledge is important to inform policy to better enable young people to become independent, families to both earn a living and care well for their children, and older people to be productive and socially engaged.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100735
Funder
Australian Research Council
Funding Amount
$346,000.00
Summary
Charting work, life and well-being after the auto industry. This project aims to study the effects of industrial decline. Plans by Australia's last remaining car-makers to close local automotive assembly operations by 2016-17 are part of a major structural change in Australia’s economy and society away from manufacturing. This project will document how automotive employees and components manufacturers in Melbourne and Geelong contend with the transition. It will also explore how Federal and Vict ....Charting work, life and well-being after the auto industry. This project aims to study the effects of industrial decline. Plans by Australia's last remaining car-makers to close local automotive assembly operations by 2016-17 are part of a major structural change in Australia’s economy and society away from manufacturing. This project will document how automotive employees and components manufacturers in Melbourne and Geelong contend with the transition. It will also explore how Federal and Victorian State government transitional arrangements can safeguard manufacturing skills and occupations, mitigate socio-economic disadvantage in closure-affected communities and prevent workers and their families from sliding into precarity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100622
Funder
Australian Research Council
Funding Amount
$360,756.00
Summary
Welfare entrepreneurs and paradoxes of social control in rural China. This project aims to examine how non-state welfare systems run by local private entrepreneurs affect power relationships in contemporary rural China. Combining humanistic and social science approaches, the project expects to generate new knowledge about how welfare policies and practices interact with or develop alongside institutions of social control. Expected research outcomes include new empirical data on informal politica ....Welfare entrepreneurs and paradoxes of social control in rural China. This project aims to examine how non-state welfare systems run by local private entrepreneurs affect power relationships in contemporary rural China. Combining humanistic and social science approaches, the project expects to generate new knowledge about how welfare policies and practices interact with or develop alongside institutions of social control. Expected research outcomes include new empirical data on informal political processes and institutional development in post-Socialist economies. This will enhance the basis for scholarly theory and provide commercial and governmental organisations with the information and conceptual tools to accurately assess the priorities of their Chinese partners, competitors, or counterparts.Read moreRead less