Pharmacogenetic And Structural Investigation Of The Omega Class Glutathione Transferases
Funder
National Health and Medical Research Council
Funding Amount
$490,020.00
Summary
Members of the family of enzymes known as glutathione transferases are known to be responsible for the metabolism and detoxification of a wide range of compounds including therapeutic drugs and cancer causing chemicals. Genetic variation in an individual's compliment of glutathione transferases can alter their response to drug treatment or their susceptibility to cancer. The Omega class of glutathione transferases are important because they are involved in the metabolism of arsenic and because t ....Members of the family of enzymes known as glutathione transferases are known to be responsible for the metabolism and detoxification of a wide range of compounds including therapeutic drugs and cancer causing chemicals. Genetic variation in an individual's compliment of glutathione transferases can alter their response to drug treatment or their susceptibility to cancer. The Omega class of glutathione transferases are important because they are involved in the metabolism of arsenic and because they have been shown to influence the age-at-onset of both Alzheimer s and Parkinson s diseases. The present studies will investigate the structure and function of different Omega class glutathione transferases and determine how they interact with arsenic based drugs. These studies will attempt to determine why the toxicity of arsenic varies between individuals and aims to prevent adverse reactions to arsenic containing drugs used in cancer therapy. These studies will also investigate the mechanism by which the inheritance of certain forms of Omega class glutathione transferase can affect the age at-onset of Alzheimer s disease and Parkinson s disease. The understanding of this mechanism may provide the basis for a therapy that could delay or prevent the onset of these common diseases.Read moreRead less
Trade unionism and trade union aid in Indonesia, Malaysia and Timor- Leste. This project will trace flows of trade union aid to Indonesia, Malaysia and Timor Leste and analyses its impact on local labour movements. It will provide valuable information about the trade unions and industrial relations systems of each country, and new insights into the international politics and practice of the international labour movement.
Discovery Early Career Researcher Award - Grant ID: DE130100958
Funder
Australian Research Council
Funding Amount
$374,702.00
Summary
Crime and change in urban communities: a longitudinal study of violence, community networks and the collective capacity for action. This project examines the community contexts that influence the spatial variation of violence over time. It will identify the structural conditions of the community that cause crime and the mediating effects of dynamic community processes. The results will identify the critical factors that lead to the persistence or cessation of violence.
Discovery Early Career Researcher Award - Grant ID: DE130100468
Funder
Australian Research Council
Funding Amount
$365,144.00
Summary
Decentralisation in India and Indonesia: how non-government organisations affect citizens' encounters and experiences of local level governance. This project critically examines how local non-government organisations affect decentralisation in India and Indonesia. It offers new understandings of the potential for development agencies to transform the meanings, practices and identities that shape how citizens experience local governance.
The Just-in-Time Self: Young Men, Skill and Narratives of Aspiration in the New Economy. Employers and policy-makers frequently lament the 'skills gap': the shortage of workers with the skills required to perform the available jobs. This cannot be solved simply by funding more vocational training courses. To improve participation in training it is important to understand how vocational aspirations are formed. This research will demonstrate how, through their involvement in collective creative pr ....The Just-in-Time Self: Young Men, Skill and Narratives of Aspiration in the New Economy. Employers and policy-makers frequently lament the 'skills gap': the shortage of workers with the skills required to perform the available jobs. This cannot be solved simply by funding more vocational training courses. To improve participation in training it is important to understand how vocational aspirations are formed. This research will demonstrate how, through their involvement in collective creative projects, young men from poor backgrounds, develop skills and inclinations that might move them beyond the traditional model of manual labour to develop the flexibility required of workers in the 'new economy'.Read moreRead less
The time of our lives: Time equity and the balancing of market and non-market production in the modern Australian population. This project will yield new information relevant to the national social inclusion agenda and the research priority goal of understanding and strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, fulfilling lives. Through a multilayered analysis of gender, class, life course stage, time allocation and the connection ....The time of our lives: Time equity and the balancing of market and non-market production in the modern Australian population. This project will yield new information relevant to the national social inclusion agenda and the research priority goal of understanding and strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, fulfilling lives. Through a multilayered analysis of gender, class, life course stage, time allocation and the connections between them, it will demonstrate links between various forms of social and economic participation and identify how they could be distributed more evenly. This knowledge is important to inform policy to better enable young people to become independent, families to both earn a living and care well for their children, and older people to be productive and socially engaged.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100735
Funder
Australian Research Council
Funding Amount
$346,000.00
Summary
Charting work, life and well-being after the auto industry. This project aims to study the effects of industrial decline. Plans by Australia's last remaining car-makers to close local automotive assembly operations by 2016-17 are part of a major structural change in Australia’s economy and society away from manufacturing. This project will document how automotive employees and components manufacturers in Melbourne and Geelong contend with the transition. It will also explore how Federal and Vict ....Charting work, life and well-being after the auto industry. This project aims to study the effects of industrial decline. Plans by Australia's last remaining car-makers to close local automotive assembly operations by 2016-17 are part of a major structural change in Australia’s economy and society away from manufacturing. This project will document how automotive employees and components manufacturers in Melbourne and Geelong contend with the transition. It will also explore how Federal and Victorian State government transitional arrangements can safeguard manufacturing skills and occupations, mitigate socio-economic disadvantage in closure-affected communities and prevent workers and their families from sliding into precarity.Read moreRead less
Reducing Cardiovascular Risk In Children Born With Poor Fetal Growth: The Small Baby Omega-3 (SO3) Trial
Funder
National Health and Medical Research Council
Funding Amount
$999,791.00
Summary
Poor fetal growth affects about 10% of people, and is a risk factor for high blood pressure and heart disease in adults. There is no current treatment to reduce the increased risk of heart disease due to poor fetal growth. This study will determine whether taking fish oils during infancy reduces arterial wall thickness, a sign of the disease that causes the majority of heart attacks, and lowers blood pressure in children who had poor fetal growth.
The Australian middle class and school choice: A generational study of changing anxieties and aspirations. There have been major changes in the ways that the Australian middle class think and behave as a response to economic reforms from the 1970s. The significance of this study is to add a new element to the argument by examining changing attitudes toward public and private education and school choice - from the point of view of the urban middle class. The hypothesis is that family decisions ab ....The Australian middle class and school choice: A generational study of changing anxieties and aspirations. There have been major changes in the ways that the Australian middle class think and behave as a response to economic reforms from the 1970s. The significance of this study is to add a new element to the argument by examining changing attitudes toward public and private education and school choice - from the point of view of the urban middle class. The hypothesis is that family decisions about schooling are a major site for exploring the history of the middle class. The benefit of the study is a new analysis of the middle class from the 1950s through the changing patterns of its participation in public and private schooling. It also offers an opportunity for school choice and social equity policy makers to respond to its conclusions.Read moreRead less
Meeting the needs of older persons in Indonesia. The project aims to identify the needs of older people in rural Indonesia for income, housing, health, daily care and social interaction and the extent to which their needs are met. It also considers the efficacy of existing policy programs and how these might be improved. Today, there are 22 million Indonesians aged 60 years and over, projected to rise to 48 million by 2035. Millions of older people live in rural areas from which younger people h ....Meeting the needs of older persons in Indonesia. The project aims to identify the needs of older people in rural Indonesia for income, housing, health, daily care and social interaction and the extent to which their needs are met. It also considers the efficacy of existing policy programs and how these might be improved. Today, there are 22 million Indonesians aged 60 years and over, projected to rise to 48 million by 2035. Millions of older people live in rural areas from which younger people have moved to the rapidly growing cities. This presents challenges for the traditional family-based aged care system in Indonesia. It is expected that findings from the study will be published in a series of policy papers to be presented in the Indonesian National Development Planning Board.Read moreRead less