Translation Of Glaucoma Blindness Genes To Improve Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$856,795.00
Summary
Glaucoma is a common cause of irreversible blindness. It is currently difficult to predict which patients with the earliest signs of glaucoma will develop blinding stages of the disease. This study will investigate how genes and eye measurements can be used to predict the risk of developing severe glaucoma in people with early signs of disease. This will ensure that high risk individuals can access treatment early, while those at low risk can be spared unnecessary treatment and seen less often.
Why Is The Bone Marrow A “hot-spot” For Myeloma Plasma Cell Metastasis: Are There Gremlins In The System?
Funder
National Health and Medical Research Council
Funding Amount
$651,979.00
Summary
Most cancer patients die because their cancer spreads from a primary site to other tissues in the body. Once escaping the primary site, 70% of all tumours will spread to bone. This raises the question, why is bone a preferred destination for cancer cells? We provide evidence that Gremlin1, made by non-cancer cells within bone, is a key protein that supports cancer growth. This study will examine whether inhibiting Gremlin1 is a potential therapy to inhibit cancer spreading to bone.
Tracking Epidermal Clonal Evolution During Skin Cancer Induction And Progression
Funder
National Health and Medical Research Council
Funding Amount
$558,168.00
Summary
Skin cancer is the most frequent form of cancer in Australia and in many parts of the world. It is strongly connected to ultraviolet radiation from the sun. In this project, we will use our capacity to track individual cells, to observe the heterogeneity of tumours and the lesions that precede them. We will show the importance of this heterogeneity in tumour progression unveiling the limits of current therapies against skin cancer.
CKD-FIX: A Randomised, Controlled Trial Of Allopurinol In The Slowing Of Kidney Disease Progression
Funder
National Health and Medical Research Council
Funding Amount
$1,917,147.00
Summary
Chronic kidney disease (CKD) is a major public health problem affecting over 1.5 million Australians and is associated with increased risk of death, heart disease and progression to end-stage kidney disease (ESKD). Current treatments to slow progression to ESKD are limited. The CKD-FIX trial aims to find out whether treatment with allopurinol, a commonly used drug for gout prevention, safely and effectively slows CKD progression. This could lead to significant health and economic benefits.
Structural behaviour of innovative hollow flange steel members subject to local and lateral distortional buckling effects. This project will investigate the local and lateral distortional buckling behaviour of a new generation of innovative and cost-effective thin and high strength steel hollow flange sections (HFS) being developed using a unique dual weld and roll-forming technology. It will use experiments and advanced numerical modelling to develop fundamental behavioural and design data for ....Structural behaviour of innovative hollow flange steel members subject to local and lateral distortional buckling effects. This project will investigate the local and lateral distortional buckling behaviour of a new generation of innovative and cost-effective thin and high strength steel hollow flange sections (HFS) being developed using a unique dual weld and roll-forming technology. It will use experiments and advanced numerical modelling to develop fundamental behavioural and design data for HFS flexural members. Effects of web corrugations and punched holes will also be investigated. The research will enable innovative applications using HFS in the building industry in Australia and overseas. It will bring significant economic benefits to the industry partner, steel building industry, and Australia.Read moreRead less
Structural Behaviour of Innovative LiteSteel Beams, their Design Improvements and Applications. This project will develop a significant knowledge base, accurate design models and innovative application methods for the new LSB, which will be fully used by the collaborating partner in marketing them in Australia and overseas. Both construction and manufacturing industry sectors will benefit through the increased use of the innovative and lightweight hollow flange sections. Using the new sections a ....Structural Behaviour of Innovative LiteSteel Beams, their Design Improvements and Applications. This project will develop a significant knowledge base, accurate design models and innovative application methods for the new LSB, which will be fully used by the collaborating partner in marketing them in Australia and overseas. Both construction and manufacturing industry sectors will benefit through the increased use of the innovative and lightweight hollow flange sections. Using the new sections and the wealth of design information from this research, Australian engineers can develop cost-effective and safer building systems. Community at large, in particular rural and regional communities will gain through cheaper building systems, additional employment in LSB manufacturing and design, and opportunities locally and overseas.Read moreRead less
Understanding the performance of cold-formed steel frame wall systems in fires to design for superior fire resistance. This project will develop new light gauge steel frame (LSF) wall systems with superior fire resistance rating and associated design rules to enable innovative and safe applications of these wall systems in various building applications. This will enable expansion of the worldwide market for LSF wall systems by the industry partner.
Innovative and safe design solutions for aluminium façade systems. This project plans to develop design rules and mullion profiles to support the use of façades using aluminium members with complex shapes. The façade is of great importance to the structural safety, energy efficiency and aesthetics of a building. Commonly used façade systems are made of glass supported by aluminium mullions with complex shapes. Current aluminium design standards do not consider the instability and failures caused ....Innovative and safe design solutions for aluminium façade systems. This project plans to develop design rules and mullion profiles to support the use of façades using aluminium members with complex shapes. The façade is of great importance to the structural safety, energy efficiency and aesthetics of a building. Commonly used façade systems are made of glass supported by aluminium mullions with complex shapes. Current aluminium design standards do not consider the instability and failures caused by wind actions on facades using such complex aluminium members. This project aims to conduct full-scale tests and develop advanced numerical models to resolve several critical problems and identify designs with superior wind resistance. Based on this, the project aims to provide innovative, accurate and safe design rules for the façade engineering profession and building industry.Read moreRead less
Light steel roof and wall systems under combined wind and bushfire actions. The project aims to investigate the complex behaviour of light cold-formed-steel roof and wall systems involving localized failures under the combined action of wind and bushfire using wind suction tests at elevated temperatures combined with advanced numerical modelling. It will generate new knowledge of the behaviour and strength of cold-formed-steel roof and wall systems under bushfire conditions. Expected outcomes in ....Light steel roof and wall systems under combined wind and bushfire actions. The project aims to investigate the complex behaviour of light cold-formed-steel roof and wall systems involving localized failures under the combined action of wind and bushfire using wind suction tests at elevated temperatures combined with advanced numerical modelling. It will generate new knowledge of the behaviour and strength of cold-formed-steel roof and wall systems under bushfire conditions. Expected outcomes include new design models for wind, bushfire and cold-formed-steel Standards. This will significantly improve the bushfire safety of buildings, since non-combustible steel roof and wall systems are used as building envelopes in bushfire prone areas, but are not designed to withstand recently discovered bushfire-enhanced winds.Read moreRead less
Bearing capacities of innovative LiteSteel beams and their floor systems. This project will develop accurate bearing capacity design models for the new LiteSteel beams (LSB) to enable innovative and safe applications of LSBs in various flooring systems in buildings. Improved LSB floor systems will also be developed. This will enable expansion of the worldwide market for LSB products and systems by the industry partner.