A reliable physical model of molecular motion in crystals. The scientific benefits would flow, in the first instance, to the large national and international communities of scientists whose research makes use of the results of X-ray diffraction experiments. Applications of the research to amino acids and peptides will benefit investigations into the structure and molecular dynamics of biological systems, including proteins and enzymes. Studies of charge densities in crystals will obtain a standa ....A reliable physical model of molecular motion in crystals. The scientific benefits would flow, in the first instance, to the large national and international communities of scientists whose research makes use of the results of X-ray diffraction experiments. Applications of the research to amino acids and peptides will benefit investigations into the structure and molecular dynamics of biological systems, including proteins and enzymes. Studies of charge densities in crystals will obtain a standard tool for improved modelling of molecular motion, resulting in physically more realistic charge density functions, and hence greater insight into the relationship between properties of crystals and their constituent molecules.Read moreRead less
The role of water uptake in novel all solid-state polymeric ion sensors. This research will enable the development of robust all solid-state polymeric ion sensors based on unplasticized copolymers. Significantly, the physical and chemical robustness of these copolymer ion sensors will allow their widespread use in new and exciting analytical applications, e.g., in-situ analysis of environmental samples in submersible instruments, clinical analysis of whole blood, in-vivo use of miniaturized ele ....The role of water uptake in novel all solid-state polymeric ion sensors. This research will enable the development of robust all solid-state polymeric ion sensors based on unplasticized copolymers. Significantly, the physical and chemical robustness of these copolymer ion sensors will allow their widespread use in new and exciting analytical applications, e.g., in-situ analysis of environmental samples in submersible instruments, clinical analysis of whole blood, in-vivo use of miniaturized electrodes in biological media, especially single cells and minute samples in biology and forensic science, etc. Extensive use of neutron characterization techniques aligns strongly this project with the new OPAL reactor to be commissioned in 2007.Read moreRead less
Accessory Mineral Microstructure and Implications for Geochronology. U-Pb geochronology of accessory minerals is widely used to constrain the timing of igneous, metamorphic and sedimentary processes. However, our current knowledge of isotope mobility in these important minerals cannot readily explain some common features of U-Pb dating. Using new developments in quantitative microstructural analysis integrated with high spatial resolution geochronology we will constrain the relationship between ....Accessory Mineral Microstructure and Implications for Geochronology. U-Pb geochronology of accessory minerals is widely used to constrain the timing of igneous, metamorphic and sedimentary processes. However, our current knowledge of isotope mobility in these important minerals cannot readily explain some common features of U-Pb dating. Using new developments in quantitative microstructural analysis integrated with high spatial resolution geochronology we will constrain the relationship between accessory minerals deformation and its effect on radiometric ages. Our results will lead to a better understanding of geochemical modification of accessory minerals and may lead to the development of new applications of geochronology and improve the dating of rock deformation.Read moreRead less
Evolution of a two billion year subduction zone: Insights from the integration of microstructure and geochronology. The dynamic evolution of the earth is fundamentally linked to its thermal history. Since, the internal heat production of the earth has changed over time, plate tectonic processes may also have changed over earth history. The manner and timing of this change is highly controversial. We aim to address the nature of tectonic processes 2 billion years ago by studying one of the wor ....Evolution of a two billion year subduction zone: Insights from the integration of microstructure and geochronology. The dynamic evolution of the earth is fundamentally linked to its thermal history. Since, the internal heat production of the earth has changed over time, plate tectonic processes may also have changed over earth history. The manner and timing of this change is highly controversial. We aim to address the nature of tectonic processes 2 billion years ago by studying one of the world's oldest subduction zones (the Usagarian belt in Tanzania). The geometry, kinematics and deformation history of the subduction complex will be integrated with radiometric age dating to quantify the style and rates of ancient tectonic processes.Read moreRead less
Biomechanics of Needle Insertion. Needle insertion is one of the most common neurosurgical procedures. However, the biomechanics of this process is poorly understood. The unknown factors include brain tissue deformation under load imposed by the needle and needle deflection when penetrating brain tissue. We will develop computational models of needle insertion. They will include non-linear material properties of the brain tissue, large deformations, and needle-tissue contact model including fric ....Biomechanics of Needle Insertion. Needle insertion is one of the most common neurosurgical procedures. However, the biomechanics of this process is poorly understood. The unknown factors include brain tissue deformation under load imposed by the needle and needle deflection when penetrating brain tissue. We will develop computational models of needle insertion. They will include non-linear material properties of the brain tissue, large deformations, and needle-tissue contact model including friction. The Japanese group will develop testing methods to validate mathematical models. Experimental set-up includes bi-axial x-ray to measure deformation within the tissue and needle deflection, and a sensor measuring reaction force on needle tip and friction force on needle sides.Read moreRead less
Computational biomechanics for image-guided neurosurgery. Our results will lead to significant improvements to the efficacy and efficiency of image-guided neurosurgery for brain tumours. Visualisation of the intra-operative configuration of the patient's brain, obtained by sparse intra-operative MRI, merged with high resolution pre-operative imaging data will become possible. In current practice, the neurosurgeon must mentally fuse the information from pre-operative fMRI and DTI by projecting it ....Computational biomechanics for image-guided neurosurgery. Our results will lead to significant improvements to the efficacy and efficiency of image-guided neurosurgery for brain tumours. Visualisation of the intra-operative configuration of the patient's brain, obtained by sparse intra-operative MRI, merged with high resolution pre-operative imaging data will become possible. In current practice, the neurosurgeon must mentally fuse the information from pre-operative fMRI and DTI by projecting it through the 3D spatial and temporal changes the patient's brain has undergone. We propose to replace this mental fusion with computations based on the biomechanical model that will allow visualisation of the transformed pre-operative data matched to the current shape of the patient's brain.Read moreRead less
Application of flow-round penetrometers for characterising soft sediments. Soft sediments present unique challenges in geotechnical engineering due to their sensitivity to disturbance during sampling. Strength measurement therefore relies on field tests, and novel penetrometers that force soil to flow around the probe have the potential for significantly improved accuracy compared with conventional cone penetrometers. The project aims to establish a definitive framework for interpreting result ....Application of flow-round penetrometers for characterising soft sediments. Soft sediments present unique challenges in geotechnical engineering due to their sensitivity to disturbance during sampling. Strength measurement therefore relies on field tests, and novel penetrometers that force soil to flow around the probe have the potential for significantly improved accuracy compared with conventional cone penetrometers. The project aims to establish a definitive framework for interpreting results of field tests using flow-round penetrometers, through careful comparison of laboratory and field strength measurements. Applications of the work range from characterising deepwater sediments for offshore developments, to monitoring the strength of pastes in the mining and materials handling industries.Read moreRead less
Physical modelling of on-bottom pipelines and offshore anchoring systems. The collaborative research programme will consist of physical modelling of suction caissons, piles and pipeline sections in order to advance the geotechnical design of deepwater facilities for offshore hydrocarbon production. The collaboration will underpin new technologies, such as steel catenary risers and suction caissons for deepwater anchoring, providing benchmark data for the validation of analysis tools. Benefits al ....Physical modelling of on-bottom pipelines and offshore anchoring systems. The collaborative research programme will consist of physical modelling of suction caissons, piles and pipeline sections in order to advance the geotechnical design of deepwater facilities for offshore hydrocarbon production. The collaboration will underpin new technologies, such as steel catenary risers and suction caissons for deepwater anchoring, providing benchmark data for the validation of analysis tools. Benefits also include the exchange of recent technical advances between geotechnical centrifuge facilities in Australia, France and the UK, all of whom are active in modelling offshore foundation systems, ensuring that Australian research remains at the forefront of world best-practice.Read moreRead less
Development of cyclic loading models for application in offshore geotechnics. The response of foundations for offshore structures to repetitive (cyclic) loads is a critical but still inadequately understood area of offshore geotechnics, with designs still usually based on simple modifications to monotonic loading conditions. In this project, a definitive framework for modelling cyclic behaviour will be established. Using this new approach, numerical models will be developed to address problems a ....Development of cyclic loading models for application in offshore geotechnics. The response of foundations for offshore structures to repetitive (cyclic) loads is a critical but still inadequately understood area of offshore geotechnics, with designs still usually based on simple modifications to monotonic loading conditions. In this project, a definitive framework for modelling cyclic behaviour will be established. Using this new approach, numerical models will be developed to address problems at all scales from fundamental constitutive behaviour of soils to macroscopic models for large foundation systems. Their application to offshore design problems (for renewable energy as well as traditional oil and gas applications) will be assessed. Recommendations to current international guidelines will also be made.Read moreRead less
Blocking of the interfaces of polymeric ion sensors - implications for novel sensor applications. Control of the transmembrane fluxes of polymeric ion sensors represents a paradigm shift that has revolutionised the use of these analytically important devices. This project will develop and characterise innovative methods for controlling these fluxes by using blocked interfaces, and this has important ramifications for the development of robust and reliable sensors, as well as novel biosensors.