Molecular signatures of complex photodissociation reactions. All energy on earth comes from the sun, either directly (e.g photosynthesis) or indirectly (e.g fossil fuels). Photochemistry is the study of how this light is absorbed and what happens to a molecule afterwards. Despite significant experimental and theoretical advances in the past decade (some in our lab), scientists still cannot predict the outcomes of most photochemical reactions. In this project we will determine the reactivity o ....Molecular signatures of complex photodissociation reactions. All energy on earth comes from the sun, either directly (e.g photosynthesis) or indirectly (e.g fossil fuels). Photochemistry is the study of how this light is absorbed and what happens to a molecule afterwards. Despite significant experimental and theoretical advances in the past decade (some in our lab), scientists still cannot predict the outcomes of most photochemical reactions. In this project we will determine the reactivity of several small, fundamental organic molecules. Not only are these molecules pollutants around our cities, but discovery of how they react in the presence of light will allow us to understand and predict the photochemistry of a much wider range of organic species.Read moreRead less
Developing the Helium Atom Pinhole Camera. The tantalising possibility of an optical instrument that uses neutral atom beams to image surfaces, rather than light or electrons, has been a grand challenge in Physics ever since de Broglie first postulated the existence of matter waves . This project seeks to realise this seminal goal using an elegantly simple design based on the concept of a pin hole camera. The successful development of this world-first instrument would represent a significant adv ....Developing the Helium Atom Pinhole Camera. The tantalising possibility of an optical instrument that uses neutral atom beams to image surfaces, rather than light or electrons, has been a grand challenge in Physics ever since de Broglie first postulated the existence of matter waves . This project seeks to realise this seminal goal using an elegantly simple design based on the concept of a pin hole camera. The successful development of this world-first instrument would represent a significant advance in helium atom microscopy and would significantly enhance the reputation of Australian science. Moreover, this project strengthens and supports a key collaboration between the Universities of Newcastle and Cambridge and is at the core of this emerging technology.Read moreRead less
Imaging with Neutral Atomic Beams: A Completely New Tool for Nanotechnology. The tantalising possibility of building an optical instrument that uses neutral atom beams to image surfaces, rather than light or electrons, has long been a goal of physical scientists across the world. This project aims to realise this goal using an elegantly simple design based on the concept of a pin hole camera. The successful development of this world-first instrument would represent a significant advance in heliu ....Imaging with Neutral Atomic Beams: A Completely New Tool for Nanotechnology. The tantalising possibility of building an optical instrument that uses neutral atom beams to image surfaces, rather than light or electrons, has long been a goal of physical scientists across the world. This project aims to realise this goal using an elegantly simple design based on the concept of a pin hole camera. The successful development of this world-first instrument would represent a significant advance in helium atom microscopy and would significantly enhance the reputation of Australian science. Moreover, this project maintains the position of Australian researchers and students at the core of this emerging technology.Read moreRead less
Active polymer surfaces for control of fluid movement. The realisation of a diverse array of remote or portable chemical/biological monitoring systems depends on the development of low power fluid management protocols. The use of appropriate conducting polymer surfaces should enable this to occur. We envisage the integration of these fluid management platforms into portable, remote autonomous monitoring systems for environmental industrial and biomedical applications.
Nanotribology and Nanorheometry: A Fundamental Study of the Dynamic Interactions of Particles and Surfaces at the Molecular Level. Friction and deformation occur from the mutual motion and interaction of microscopic particles and surfaces. This research aims to develop new theories and measurement techniques for these non-equilibrium phenomena by combining mathematical analysis and numerical computations with dynamic force measurement, surface modification, and surface characterisation on nanom ....Nanotribology and Nanorheometry: A Fundamental Study of the Dynamic Interactions of Particles and Surfaces at the Molecular Level. Friction and deformation occur from the mutual motion and interaction of microscopic particles and surfaces. This research aims to develop new theories and measurement techniques for these non-equilibrium phenomena by combining mathematical analysis and numerical computations with dynamic force measurement, surface modification, and surface characterisation on nanometre and molecular length scales. These insights and data will be critically important in designing low-friction surfaces that save energy and wear, in developing nanoscopic probes for the mechanical and structural properties of soft polymeric and bio-materials, and in making high performance coatings that control adhesion and particle aggregation in technologically advanced applications.Read moreRead less
Mineral Physics of the Earth's Core. Most information on the nature of Earth's core properties has come from teleseismic studies, which detect weak earthquake-wave signals that have traversed the Earth's deepest interior. These studies have revealed several unusual and enigmatic phenomena in the core, but interpretation of these observations must rely on mineral-physics data on the materials of the core (e.g. iron-based alloys). This project will create a unique world-class ultra-high pressure l ....Mineral Physics of the Earth's Core. Most information on the nature of Earth's core properties has come from teleseismic studies, which detect weak earthquake-wave signals that have traversed the Earth's deepest interior. These studies have revealed several unusual and enigmatic phenomena in the core, but interpretation of these observations must rely on mineral-physics data on the materials of the core (e.g. iron-based alloys). This project will create a unique world-class ultra-high pressure laboratory to obtain such data. By defining the composition and mineralogy of Earth's core, it will place Australia in the forefront of this exciting research field, and will also represent a major national resource for the study of novel materials at extreme conditions.Read moreRead less
The Application of Chemical Force Microscopy for Monitoring DNA Hybridization: A New Sensing Concept Capable of Detecting Single Molecules. This proposal outlines a method of monitoring DNA sequences with such high sensitivity that a single molecule may be detected. Such sensitivity is achieved using an atomic force microscope (AFM) to measure surface forces. Modifying an AFM tip with a single strand of DNA allows the complementary strand (the target) to be recognized via hybridization to form ....The Application of Chemical Force Microscopy for Monitoring DNA Hybridization: A New Sensing Concept Capable of Detecting Single Molecules. This proposal outlines a method of monitoring DNA sequences with such high sensitivity that a single molecule may be detected. Such sensitivity is achieved using an atomic force microscope (AFM) to measure surface forces. Modifying an AFM tip with a single strand of DNA allows the complementary strand (the target) to be recognized via hybridization to form the double helix. The occurrence of hybridization is determined by differences in surface force measurements compared with when only the single strand of DNA is present. In this way DNA samples can be analyzed without amplification; a major advance for DNA diagnostics.Read moreRead less
Molecular Fingerprinting: Forensic Spectroscopy of Trace Gases. Safeguarding Australia from terrorism, crime and invasive diseases is essential to securing our national infrastructure. This project will develop national capabilities in anticipating and responding to critical threats to society. The scientific instrumentation developed from this effort will enhance Australia's potential aid for early detection of explosive and chemical weaponry and also in the analysis of crime scenes. This rese ....Molecular Fingerprinting: Forensic Spectroscopy of Trace Gases. Safeguarding Australia from terrorism, crime and invasive diseases is essential to securing our national infrastructure. This project will develop national capabilities in anticipating and responding to critical threats to society. The scientific instrumentation developed from this effort will enhance Australia's potential aid for early detection of explosive and chemical weaponry and also in the analysis of crime scenes. This research will significantly improve our abilities to maintain the operational advantage of Australia's security agencies through superior capabilities in threat detection.Read moreRead less
New insights into free radical reactivity via gas phase studies of radical anions. Free radicals are known to be critical reactive intermediates in chemical processes ranging from the formation of photochemical smog, through combustion to the onset of age-related diseases. This research increases our understanding of how free radicals react and will thus allow for more accurate prediction, and in some instances greater control, of the outcomes of chemical reactions and their health and environme ....New insights into free radical reactivity via gas phase studies of radical anions. Free radicals are known to be critical reactive intermediates in chemical processes ranging from the formation of photochemical smog, through combustion to the onset of age-related diseases. This research increases our understanding of how free radicals react and will thus allow for more accurate prediction, and in some instances greater control, of the outcomes of chemical reactions and their health and environmental consequences. New instrumental technologies will be developed and young Australian researchers will be trained here, and with collaborators in the USA, in state-of-the-art techniques (particularly in mass spectrometry) that are essential to our emerging technology-based economy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238397
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
A ROBOTIC NMR SPECTROMETER FOR ACCELERATED DRUG DISCOVERY. The aim is to establish a facility that will use a robotic NMR instrument to help in the characterisation of drug-protein interactions and in the discovery of new drugs or agrichemicals. The significance is that with the wealth of new information arising on protein sequences from genomics programs there is an urgent need to accelerate the rate of discovery of ligands that bind to these proteins. Such ligands may provide useful drug lea ....A ROBOTIC NMR SPECTROMETER FOR ACCELERATED DRUG DISCOVERY. The aim is to establish a facility that will use a robotic NMR instrument to help in the characterisation of drug-protein interactions and in the discovery of new drugs or agrichemicals. The significance is that with the wealth of new information arising on protein sequences from genomics programs there is an urgent need to accelerate the rate of discovery of ligands that bind to these proteins. Such ligands may provide useful drug leads or help in defining the function of newly discovered proteins. The outcomes will be new knowledge on protein structure and function, and potentially, new bio-active molecules.Read moreRead less