In depth characterisation of the gamma delta T cell immune synapse. This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-ski ....In depth characterisation of the gamma delta T cell immune synapse. This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-skilled techniques, including cryo-electron microscopy and single-molecule imaging and holds ancillary benefits to postgraduate students. Anticipated outcomes include influential publications, building a critical mass of expertise in Australia and fostering international collaborations with Australia at the epicentre.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100876
Funder
Australian Research Council
Funding Amount
$413,000.00
Summary
Smart Optimisation of Functionally Graded Porous Structures. This project aims to develop a novel smart optimisation method for shaping the porosity geometries of metal foams for design requirements. Although these functionally graded porous structures have superior engineering properties, efficient examination methods to understand the mechanical behaviour of irregular graded porosities are lacking. Expected outcomes of this project include the expansion of fundamental knowledge in porous media ....Smart Optimisation of Functionally Graded Porous Structures. This project aims to develop a novel smart optimisation method for shaping the porosity geometries of metal foams for design requirements. Although these functionally graded porous structures have superior engineering properties, efficient examination methods to understand the mechanical behaviour of irregular graded porosities are lacking. Expected outcomes of this project include the expansion of fundamental knowledge in porous media and new technologies to build stronger and lighter multifunctional structural components. The project will provide significant benefits, including enhanced manufacturing capacities of local industries to fabricate metal foam products, new job opportunities in a growing market, and less carbon emissions.Read moreRead less
3D integrated crystalline UV optical lens-fiber couplers for astronomy. This project aims to create micro-optics for astronomical and bio medical applications by 3D sculpturing them out of crystals by ultra-short pulse lasers. This project will introduce a new 3D fabrication approach of optical probes which have self-aligned micro-optical elements and optical fibres for a wide spectral range and with high quality optical surfaces. Expected outcomes of this project include building new capabiliti ....3D integrated crystalline UV optical lens-fiber couplers for astronomy. This project aims to create micro-optics for astronomical and bio medical applications by 3D sculpturing them out of crystals by ultra-short pulse lasers. This project will introduce a new 3D fabrication approach of optical probes which have self-aligned micro-optical elements and optical fibres for a wide spectral range and with high quality optical surfaces. Expected outcomes of this project include building new capabilities in micro-optical probes for industrial environments, establishing new solutions for international astronomy partners, and developing new techniques to image through optical fibres. This should provide significant benefits by improving astronomical instrumentation and also lead to less invasive endoscopy.Read moreRead less
Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to ....Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to safe, affordable, and environmentally sustainabe modular building construction. The project will provide significant benefits to designers, manufacturers and regulators to improve the resilience of the building stock and to support greater design and manufacturing innovations.Read moreRead less
Developing innovative concrete composites by upscaling material properties. This project aims to develop an upscaling process to correlate micro-nano properties of engineering materials to their comprehensive physicochemical properties based on systematic mechanical and statistical analysis approaches and nanoindentation technology. The process will enable assessing material mechanical and viscoelastic properties at a microscale level thus will generate a new knowledge in structural engineering ....Developing innovative concrete composites by upscaling material properties. This project aims to develop an upscaling process to correlate micro-nano properties of engineering materials to their comprehensive physicochemical properties based on systematic mechanical and statistical analysis approaches and nanoindentation technology. The process will enable assessing material mechanical and viscoelastic properties at a microscale level thus will generate a new knowledge in structural engineering discipline including health monitoring, assessment of existing structures, historical buildings, and strengthening and repairing materials in structures. The outcomes are a multiscale link model for upscaling material properties and a development of innovative reinforced concrete composites which are cost-effective and efficient.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100136
Funder
Australian Research Council
Funding Amount
$1,100,000.00
Summary
High Performance Solid State NMR Spectroscopy for Materials Research. The project will support research in a diverse set of fields such as biomedical engineering catalysis, energy storage and waste recovery, with cutting edge next-generation solid state (400 MHz) nuclear magnetic resonance capabilities and research expertise. The system enabling high sensitivity, high throughput analysis over extended temperature range will enable addressing of fundamental questions regarding the structure-prope ....High Performance Solid State NMR Spectroscopy for Materials Research. The project will support research in a diverse set of fields such as biomedical engineering catalysis, energy storage and waste recovery, with cutting edge next-generation solid state (400 MHz) nuclear magnetic resonance capabilities and research expertise. The system enabling high sensitivity, high throughput analysis over extended temperature range will enable addressing of fundamental questions regarding the structure-property relationships of advanced functional materials. Accessible to a wide user base in fundamental and applied research, in medicine, energy, catalysis and recycling of waste, the project will extend the current facilities to develop Sydney as regional centre for advanced solid state nuclear magnetic resonance analysis.Read moreRead less
Fire engineering of prefabricated structural systems of modular buildings. With the speed and cost benefits, modular construction is considered a game-changing solution in response to pandemics and natural disasters, and tackling the affordable housing crisis on a large scale. However, its uptake has been hindered due to recent fire incidents of modular buildings. This project aims to develop novel fire experiments and advanced modelling techniques to evaluate the fire performance of modular bui ....Fire engineering of prefabricated structural systems of modular buildings. With the speed and cost benefits, modular construction is considered a game-changing solution in response to pandemics and natural disasters, and tackling the affordable housing crisis on a large scale. However, its uptake has been hindered due to recent fire incidents of modular buildings. This project aims to develop novel fire experiments and advanced modelling techniques to evaluate the fire performance of modular buildings. Computational tools and fire safety design guidelines will also be developed to enable modular buildings to be built safer and more economically. This project will promote the widespread adoption of modular buildings to benefit end-users and the wider society, especially the housing sector and low-income households.Read moreRead less