Complex Interfaces and Solid-State Precipitation in Advanced Materials. Solid-state precipitates are key features of the microstructures of many natural and artificial materials and govern their properties. Yet understanding, let alone designing, the microstructures of materials remains a formidable challenge. The recent discovery of a new class of embedded interfaces in aluminium alloys offers the prospect of determining the atomic-scale mechanisms of precipitation. This project aims to apply t ....Complex Interfaces and Solid-State Precipitation in Advanced Materials. Solid-state precipitates are key features of the microstructures of many natural and artificial materials and govern their properties. Yet understanding, let alone designing, the microstructures of materials remains a formidable challenge. The recent discovery of a new class of embedded interfaces in aluminium alloys offers the prospect of determining the atomic-scale mechanisms of precipitation. This project aims to apply the latest microscopy and computational techniques synergistically to characterise such interfaces and develop atomic-scale mechanisms of nucleation and growth in model alloy systems. It is expected that this work will constitute a major step towards practical control of solid-state precipitation in technologically important materials.Read moreRead less
Highly efficient X-ray storage phosphor for medical and scientific imaging. X-rays are invaluable in medical diagnostics. For example, they are widely used in breast screening programs. However,they can cause cancer even at low doses. Consequently there is a global effort to reduce the X-ray dose by exploring more efficient imaging technologies. The present proposal seeks to exploit our recent discovery of a highly efficient storage phosphor that has the potential to facilitate substantial X-r ....Highly efficient X-ray storage phosphor for medical and scientific imaging. X-rays are invaluable in medical diagnostics. For example, they are widely used in breast screening programs. However,they can cause cancer even at low doses. Consequently there is a global effort to reduce the X-ray dose by exploring more efficient imaging technologies. The present proposal seeks to exploit our recent discovery of a highly efficient storage phosphor that has the potential to facilitate substantial X-ray dose reduction; this is of greatest significance to the general population. Also, the phosphor facilitates higher resolution images, a feature that is highly important in scientific imaging. This project may lead to substantial revenue streams for the nation because it taps into a global multibillion dollar industry.Read moreRead less
Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms t ....Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms that regulate the signalosomes. The intended outcome is to answer the long-standing question of control of speed and amplitude of innate immune response at the molecular level. Both locally and internationally, this new approach should provide benefits across structural biology, molecular evolution and biotechnology.Read moreRead less
In depth characterisation of the gamma delta T cell immune synapse. This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-ski ....In depth characterisation of the gamma delta T cell immune synapse. This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-skilled techniques, including cryo-electron microscopy and single-molecule imaging and holds ancillary benefits to postgraduate students. Anticipated outcomes include influential publications, building a critical mass of expertise in Australia and fostering international collaborations with Australia at the epicentre.Read moreRead less
Locating Atoms by Observing Crystallographic Phase. Atomic structures are determined by measuring how they scatter radiation. However half of the necessary information, the crystallographic phase, cannot be measured from the scattered intensity. For a century the only option has been to deduce the phase via the statistical analysis of thousands of intensity measurements. This project aims to develop a method to determine atomic structures from the direct observation of phase. From a handful of o ....Locating Atoms by Observing Crystallographic Phase. Atomic structures are determined by measuring how they scatter radiation. However half of the necessary information, the crystallographic phase, cannot be measured from the scattered intensity. For a century the only option has been to deduce the phase via the statistical analysis of thousands of intensity measurements. This project aims to develop a method to determine atomic structures from the direct observation of phase. From a handful of observations and no formal measurements, atoms can be located with picometre precision. It is predicted that this method will be direct, rapid and unequivocal, sensitive to light atoms and applicable to nanostructures, which will represent a paradigm shift in crystallography.Read moreRead less
Interaction of Local and Distortional Buckling in Thin-Walled High Strength Steel Sections. Recent research at the University of Sydney has shown that the local and distortional buckling modes in thin-walled high strength steel sections may have adverse interaction. Cold-Formed steel sections of this type are used in residential construction, ceiling systems, partitioning systems in offices and other light gauge applications. The project will develop mathematical models of the interaction beha ....Interaction of Local and Distortional Buckling in Thin-Walled High Strength Steel Sections. Recent research at the University of Sydney has shown that the local and distortional buckling modes in thin-walled high strength steel sections may have adverse interaction. Cold-Formed steel sections of this type are used in residential construction, ceiling systems, partitioning systems in offices and other light gauge applications. The project will develop mathematical models of the interaction behaviour of sections of this type for a wide range of section geometries. A major outcome will be design methods which accurately quantify the interaction behaviour based on the models. Testing will be undertaken to support the theoretical developments and to calibrate the design models.Read moreRead less
Imaging defects at atomic resolution via state-of-the-art atomic force microscopy and petascale simulations. Atomic force microscopy (AFM) promises to deliver resolution of individual atoms on surfaces and therefore, in principle, is capable of observing surface defects. However, the image obtained is a convolution of many complex interactions. Thus the key questions are what is being actually observed when we see something with “atomic resolution” in AFM and can point defects be really detected ....Imaging defects at atomic resolution via state-of-the-art atomic force microscopy and petascale simulations. Atomic force microscopy (AFM) promises to deliver resolution of individual atoms on surfaces and therefore, in principle, is capable of observing surface defects. However, the image obtained is a convolution of many complex interactions. Thus the key questions are what is being actually observed when we see something with “atomic resolution” in AFM and can point defects be really detected? The aim of this proposal is to combine state-of-the-art experimental AFM techniques with computer simulations that are capable of generating AFM images to answer these questions. Our ability to harness the potential of AFM for many applications in areas such as nanoscience and crystal engineering hinges on being able to correctly interpret AFM images.Read moreRead less
Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team ....Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team recently invented the scanning helium atom microscope (SHeM), which can image surfaces non-destructively with nanoscale resolution. They will use the SHeM to determine the new fundamental physics that underpins the imaging mechanism. Outcomes include turning SHeM into a tool that materials and biological scientists can use in laboratories worldwide.Read moreRead less
Reliability and design of 3D printed metal structures. The project will produce a design framework for additively manufactured (3D printed) metal structures. The project will develop open source algorithms for predicting (i) mechanical properties of 3D printed metals for given printing parameters and (ii) internal stresses and distortions arising from the printing process. Underpinned by experiments on structural components and structural reliability analyses, models will be calibrated for the n ....Reliability and design of 3D printed metal structures. The project will produce a design framework for additively manufactured (3D printed) metal structures. The project will develop open source algorithms for predicting (i) mechanical properties of 3D printed metals for given printing parameters and (ii) internal stresses and distortions arising from the printing process. Underpinned by experiments on structural components and structural reliability analyses, models will be calibrated for the nonlinear analysis of 3D printed structures, and a methodology will be set out for designing 3D printed metal structures with acceptably low probability of failure. The project will enable structural engineers to safely and efficiently design 3D printed metal structures and components.Read moreRead less
Complete limit state analysis of steel structural framework. This project aims to produce a design-by-analysis method for steel frameworks that explicitly models the complete set of failure modes including fracture of connections. The project will develop models that can accurately predict the fracture behaviour of welded and bolted connections, and system reliability calibrations that account for random variations in the parameters controlling the strength of steel frameworks including fracture ....Complete limit state analysis of steel structural framework. This project aims to produce a design-by-analysis method for steel frameworks that explicitly models the complete set of failure modes including fracture of connections. The project will develop models that can accurately predict the fracture behaviour of welded and bolted connections, and system reliability calibrations that account for random variations in the parameters controlling the strength of steel frameworks including fracture. The outcomes of this project will advance the design of steel structures, as it will become possible to analyse any type of structure for any type of failure including fracture. The design method will enable Australian structural engineers to enhance their competitive edge internationally, and maintain their preeminent record of producing innovative structural solutions.Read moreRead less