Drug-induced Immune Thrombocytopenia: Understanding The Disease Mechanisms Is The Key To Better Treatment
Funder
National Health and Medical Research Council
Funding Amount
$509,550.00
Summary
Many very commonly used medications cause an allergic reaction in a small number of patients that receive them. The allergic reaction results in platelets being destroyed and puts the patients at risk of bleeding. The patient recovers slowly if the drug is stopped but there is no other treatment and no way to reverse the effect quickly if the patient starts to bleed. This project will try to understand the mechanism of the condition and test a potential treatment.
Does Caffeine Affect The Development Of The Very Immature Brain: Dose Response Relationship?
Funder
National Health and Medical Research Council
Funding Amount
$668,386.00
Summary
Premature birth is a major health problem worldwide. Preterm babies often develop apnoea of prematurity (AOP), which is commonly treated with caffeine. Trials indicate that preterm babies treated with low dose caffeine have less neurodevelopmental disabilities at 18 months. Higher doses of caffeine are often needed to reduce AOP but the risk of this is unknown. We will study the short and long-term effects of increasing doses of caffeine on the developing brain in a long-gestation species.
Interaction of Local and Distortional Buckling in Thin-Walled High Strength Steel Sections. Recent research at the University of Sydney has shown that the local and distortional buckling modes in thin-walled high strength steel sections may have adverse interaction. Cold-Formed steel sections of this type are used in residential construction, ceiling systems, partitioning systems in offices and other light gauge applications. The project will develop mathematical models of the interaction beha ....Interaction of Local and Distortional Buckling in Thin-Walled High Strength Steel Sections. Recent research at the University of Sydney has shown that the local and distortional buckling modes in thin-walled high strength steel sections may have adverse interaction. Cold-Formed steel sections of this type are used in residential construction, ceiling systems, partitioning systems in offices and other light gauge applications. The project will develop mathematical models of the interaction behaviour of sections of this type for a wide range of section geometries. A major outcome will be design methods which accurately quantify the interaction behaviour based on the models. Testing will be undertaken to support the theoretical developments and to calibrate the design models.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100118
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Nuclear magnetic resonance spectroscopy facilities for the Sydney region. The determination of molecular structure is crucial in the chemical and biomolecular sciences, leading to the development of new drugs and other types of molecules and providing an understanding of how molecules interact with each other. The requested equipment will provide the ability for researchers in the Sydney region to advance our knowledge at this fundamental level by expanding the number and types of experiments th ....Nuclear magnetic resonance spectroscopy facilities for the Sydney region. The determination of molecular structure is crucial in the chemical and biomolecular sciences, leading to the development of new drugs and other types of molecules and providing an understanding of how molecules interact with each other. The requested equipment will provide the ability for researchers in the Sydney region to advance our knowledge at this fundamental level by expanding the number and types of experiments that can be performed.Read moreRead less
New And Improved Treatment Strategies For Neonatal Seizures
Funder
National Health and Medical Research Council
Funding Amount
$883,209.00
Summary
Around 10% of neonates in Australia are diagnosed with seizures each year. Seizures worsen neurodevelopmental outcome following hypoxic brain injury. Despite evidence of the limited effectiveness and potential neurotoxicity of current anti-seizure medication, treatment has not changed for many decades. The objective of this study is to optimise treatment of neonatal seizures with a compound that is effective and does not cause harm, or indeed provides neuroprotection for the compromised brain.
Developing auxetic composite system for protective engineering applications. This project intends to explore the possibilities of extending the latest developments in auxetic technologies to the protective design of engineering structures. Auxetic materials become thicker perpendicular to the applied force when stretched. Specifically, the project plans to develop a novel auxetic composite system with a focus on protecting civil and defence infrastructure from extreme loads. It is expected that ....Developing auxetic composite system for protective engineering applications. This project intends to explore the possibilities of extending the latest developments in auxetic technologies to the protective design of engineering structures. Auxetic materials become thicker perpendicular to the applied force when stretched. Specifically, the project plans to develop a novel auxetic composite system with a focus on protecting civil and defence infrastructure from extreme loads. It is expected that the system’s superior energy dissipating capability will broaden its application beyond civil infrastructure, such as armoured vehicles, protective sports gear and body armour. The project also plans to develop a multiscale numerical modelling and topological optimisation framework to accelerate the adoption of this advanced composite system.Read moreRead less
Multi-Scale Model-Based Simulation of Glass Fragmentation under Blast Loading. It is estimated that most injuries from bomb blasts can be attributed to airborne sharp glass fragments. The proposed project will help us gain better understanding of glass failure mechanism under impact/blast loading. The results from the proposed project are expected to help in developing more effective blast-resistant transparency, ensuring the reliability and quality of buildings and facilities, mitigating injury ....Multi-Scale Model-Based Simulation of Glass Fragmentation under Blast Loading. It is estimated that most injuries from bomb blasts can be attributed to airborne sharp glass fragments. The proposed project will help us gain better understanding of glass failure mechanism under impact/blast loading. The results from the proposed project are expected to help in developing more effective blast-resistant transparency, ensuring the reliability and quality of buildings and facilities, mitigating injury or death due to flying glass fragments, and eventually enhancing public safety and security.Read moreRead less
Reliability and full-range analysis of joints in steel frameworks. The project has two main components, namely to establish a mechanics-based nonlinear model for representing joints in structural analyses, and a reliability framework at system level that considers randomness in the strength and behaviour of both members and joints. As its main aim, the project aims to pave the way for introducing computer-based direct design of steel frames in the structural engineering community, thus obviating ....Reliability and full-range analysis of joints in steel frameworks. The project has two main components, namely to establish a mechanics-based nonlinear model for representing joints in structural analyses, and a reliability framework at system level that considers randomness in the strength and behaviour of both members and joints. As its main aim, the project aims to pave the way for introducing computer-based direct design of steel frames in the structural engineering community, thus obviating the need for checking member and joint strengths to a structural standard. The direct design approach is more accurate, economical and faster than current design practice, provides more uniform structural system reliability, and encourages innovation in structural and architectural forms.Read moreRead less
System reliability-based criteria for designing steel structures by advanced analysis. The aim of the project is to develop a new system-based criterion for designing steel structures using advanced analysis methods. The outcome of the research will help industry to design safer and more economic steel structures, thus enabling the profession to stay competitive in the national and international marketplace.
Contribution Of Disturbed Blood Flow And Cerebral Metabolism To White Matter Damage In The Perinatal Brain
Funder
National Health and Medical Research Council
Funding Amount
$369,375.00
Summary
It has been known for some time that the white matter regions of the developing brain are particularly vulnerable to damage. These regions are deep in the brain near the ventricles, and are rich in myelin sheaths wrapped around the nerve fibres running from cell-rich areas in the outer layers of the brain to other regions, and down into the spinal cord. Damage to white matter usually leads to behavioural, learning and motor problems in the newborn infant - in its severest form, seen as cerebral ....It has been known for some time that the white matter regions of the developing brain are particularly vulnerable to damage. These regions are deep in the brain near the ventricles, and are rich in myelin sheaths wrapped around the nerve fibres running from cell-rich areas in the outer layers of the brain to other regions, and down into the spinal cord. Damage to white matter usually leads to behavioural, learning and motor problems in the newborn infant - in its severest form, seen as cerebral palsy. Such outcomes are often associated with the presence of asphyxia and infection during pregnancy, leading to the belief that the damage first arises while the baby is still in utero. In this application we suggest that asphyxia and-or infection during pregnancy cause prolonged disturbances in the regulation of blood flow and integrity of the blood-brain barrier in the developing brain, together with changes in metabolism that result in accumulation of prostaglandins and the toxic hydroxyl radical, leading irreversibly to cell death. If this series of events proves to be true, we have suggested and will test several protocols for protecting the fetal brain, which should be readily translatable to clinical practice.Read moreRead less