Investigating the molecular basis of T-cell receptor cross-reactivity. This project will explore the basis of unexpected immune reactions whereby the immune system mistakes one molecular structure for another, a phenomenon known as cross-reactivity. This project will examine how often this is due to molecular mimicry, potentially explaining why immune T cells sometimes react inappropriately to different agents.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100179
Funder
Australian Research Council
Funding Amount
$3,189,000.00
Summary
Automated high resolution and high contrast cryo -TEM for three-dimensional structural biology. This project aims to establish a facility in automated, single-particle cryo-TEM and cryo-TEM tomography (Titan Krios) that will enable atomic and molecular structure research and three-dimensional subcellular and cellular imaging. The project will span all multiscale cryo-TEM modalities from the visualisation of cells, membranes and macromolecular complexes, through to near-atomic-resolution protein ....Automated high resolution and high contrast cryo -TEM for three-dimensional structural biology. This project aims to establish a facility in automated, single-particle cryo-TEM and cryo-TEM tomography (Titan Krios) that will enable atomic and molecular structure research and three-dimensional subcellular and cellular imaging. The project will span all multiscale cryo-TEM modalities from the visualisation of cells, membranes and macromolecular complexes, through to near-atomic-resolution protein structure determination. Cryo-single particle analysis and tomography are recognised as revolutionary technologies in molecular structural biology and powerful enablers of future ground-breaking discovery. The project will deliver significant competitive advantage for Australia in leading-edge structure-based research, drug discovery, new opportunities for applied research and development, and showcasing science to the public.Read moreRead less
ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the d ....ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the design of peptides and proteins for targeted scientific, agricultural, biotechnology, animal health and pharmaceutical applications. CIPPS will assemble leading researchers from diverse disciplines to create a sustainable national entity that will drive new Australian industries and train next generation researchers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100124
Funder
Australian Research Council
Funding Amount
$538,590.00
Summary
An Advanced Ultrafast Laser Spectroscopy Facility in Queensland. The project aims to establish a world-class ultrafast laser spectroscopy facility to investigate how molecules interact with visible or ultraviolet light. Light-matter interactions are key to energy generation in nature through photosynthesis as well as everyday technologies including optical communications and displays. This project expects to generate new knowledge in on how light interacts with matter at the molecular level. Exp ....An Advanced Ultrafast Laser Spectroscopy Facility in Queensland. The project aims to establish a world-class ultrafast laser spectroscopy facility to investigate how molecules interact with visible or ultraviolet light. Light-matter interactions are key to energy generation in nature through photosynthesis as well as everyday technologies including optical communications and displays. This project expects to generate new knowledge in on how light interacts with matter at the molecular level. Expected outcomes of the ultrafast spectroscopic measurements will be understanding the fate of light absorbed by or generated in different materials. Application of the knowledge gained will enable the design of materials for more efficient technologies such as solar cells, lighting, and sensors.Read moreRead less
ARC Molecular and Materials Structure Research Network. The Network will build powerful e-Science resources for the structural sciences. Collaborative remote access will be developed for sophisticated instrumentation, including instruments planned for the Replacement Research Reactor and Australian Synchrotron. A structure database service with cross disciplinary content and versatile visualisation and analysis capabilities will further exemplify smart information use. The internet services will ....ARC Molecular and Materials Structure Research Network. The Network will build powerful e-Science resources for the structural sciences. Collaborative remote access will be developed for sophisticated instrumentation, including instruments planned for the Replacement Research Reactor and Australian Synchrotron. A structure database service with cross disciplinary content and versatile visualisation and analysis capabilities will further exemplify smart information use. The internet services will ultimately harness the Grid, enabling linkage into other national and international Grid systems. Encompassing physics, computer science, applied mathematics, chemistry and biochemistry, and catalysing interaction across these disciplines, the MMSN will impact all five National Research Priority 3 goals.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100121
Funder
Australian Research Council
Funding Amount
$670,000.00
Summary
A facility for the nanoscale imaging and characterisation of materials. Nanotechnology is dependent on measuring surface properties and this cutting-edge scanning probe microscopy facility will provide this capability. Atomic resolution imaging, along with spectroscopy for chemical information, and nanoindentation for physical information, will generate solutions for physical and life sciences, and materials engineering.
TAILORING OF CARBON MATERIALS FOR USE IN DIRECT CARBON FUEL CELLS. This project aims to develop a fundamental understanding of and methods for tailoring carbon materials to be used in high efficiency (80-85%) direct carbon fuel cells (DCFC). This project addresses an important area in clean and efficient energy supply to meet the World's long-term energy and environmental requirements. Specifically, we aim to focus on the carbon particulates based on carbon black materials with a turbostratic st ....TAILORING OF CARBON MATERIALS FOR USE IN DIRECT CARBON FUEL CELLS. This project aims to develop a fundamental understanding of and methods for tailoring carbon materials to be used in high efficiency (80-85%) direct carbon fuel cells (DCFC). This project addresses an important area in clean and efficient energy supply to meet the World's long-term energy and environmental requirements. Specifically, we aim to focus on the carbon particulates based on carbon black materials with a turbostratic structure, and to investigate the relationship between the microstructures of synthetic carbon black materials and their efficacy in DCFC systems. Ultimately, we aim to engineer novel carbon particulates for use in DCFCs.Read moreRead less
Pathways for performance improvements of organic light emitting diodes . Organic light-emitting diodes (OLEDs) represent the next generation technology for displays and lighting. Despite their rapid uptake, one of the factors limiting their application in lighting is the efficiency roll-off at high brightness. This project aims to work towards solutions for this problem using an innovative combination of simulation studies and experimental work. Expected outcomes include improved theoretical and ....Pathways for performance improvements of organic light emitting diodes . Organic light-emitting diodes (OLEDs) represent the next generation technology for displays and lighting. Despite their rapid uptake, one of the factors limiting their application in lighting is the efficiency roll-off at high brightness. This project aims to work towards solutions for this problem using an innovative combination of simulation studies and experimental work. Expected outcomes include improved theoretical and experimental approaches leading to new design rules for OLEDs. This should provide significant benefits such as a pathway for development of improved efficient, high brightness OLEDs for applications in low energy consumption lighting and long-lasting, bright displays.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100154
Funder
Australian Research Council
Funding Amount
$1,049,904.00
Summary
Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produ ....Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produce products, such as fine chemicals, pharmaceutical actives and food ingredients. The project would provide significant benefits by enabling existing and emerging companies' commercial successes and competitiveness in global markets, creating new jobs and resulting in the growth of the bio-economy in Australia.Read moreRead less