Translating Science Into Treatment For Ischemic Stroke
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
My team has pioneered research in Australia that has advanced knowledge in the delivery of safer and more effective stroke therapies. I have developed software for the automated processing of multimodal CT imaging to better select patients for stroke therapies. In order to move this cutting-edge imaging technology into routine clinical practice several processes will occur: Implementation, validation and demonstration of patient benefits, and cost effectiveness of CT imaging selection in routine
New Therapies For Stroke – Preventing Stroke Progression And Enhancing Recovery
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
Stroke is a major cause of death and disability worldwide. Dr Spratt’s team have discovered a new mechanism causing pressure to rise in the skull after stroke. They will build on their discovery of a promising new therapy to prevent early worsening of stroke and improve patient outcomes. He also leads a team studying better stroke recovery by promoting activity by enriching the rehabilitation environment, and ways to improve fitness in stroke survivors.
Word finding difficulties are the most common type of language impairment following stroke, causing considerable frustration and distress for the individual and their family and friends. Current available language therapies are not always effective. This project aims to (1) develop and test new language treatments for stroke sufferers, and (2) find out how language therapy works in the brain. Outcomes will include improved treatment of communication disorders after stroke.
Optimizing Stroke Therapy - Advanced Brain Imaging And Reperfusion Therapies
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Most stroke is due to a blocked blood vessel reducing blood flow to the brain. This research aims to optimize fast restoration of blood flow to the brain and improve patient outcomes. We will test potentially more effective clot-dissolving medication, examine potential benefits of redesigning pre-hospital ambulance transport systems and clarify the role of advanced brain imaging to maximize delivery of recently proven minimally invasive procedures to physically remove blood clots in the brain.
The Influence Of Gender And Steroid Hormones On Cerebrovascular NADPH Oxidase During Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$390,974.00
Summary
My research addresses several major questions regarding the regulation of brain blood flow and mechanisms that may contribute to stroke. There is confusion as to whether giving menopausal women hormone replacement worsens the effect of having a stroke. I propose that female hormones may lower blood flow to the brain after menopause and therefore cause more damage to the brain after stroke.
New Insights Into The Mechanisms Of Thrombogenesis In Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
Atrial fibrillation (AF) is the most common heart rhythm disturbance (arrhythmia), which is associated with a high risk of stroke due to clot formation within the left atria. At present we still only have a limited understanding of the mechanism of clot formation in AF. The aim of this study is to determine the critical mechanisms that contribute to clot formation within the left atria in AF. This knowledge is fundamental to the development of more successful interventional approaches.
Is Stroke Neurodegenerative? A Longitudinal Study Of Changes In Brain Volume And Cognition Following Stroke
Funder
National Health and Medical Research Council
Funding Amount
$290,946.00
Summary
There is no direct evidence linking Alzheimer’s Disease (AD) and stroke. It is unknown whether stroke can trigger progressive dementia in the same way as AD. In a group of stroke patients, I will measure MRI brain volume and cognition in the 5 years after stroke. These findings will be critical for identification of those patients most at risk of dementia after stroke. This may allow future early intervention for these patients, via promising AD disease-modifying therapies.
Improving The Identification, Management And Outcome Of People With Depression And Other Chronic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$476,728.00
Summary
My research is designed to reduce depression and help people with chronic disease have a better quality of life. I will work with Aboriginal and/or Torres Strait Islander communities to improve how depression is identified, prevented and treated. I will work with the general community who have major depression, depression that is difficult to treat and people with depression and chronic disease to improve their outcomes. I will also aim to improve the recovery of people who have had a stroke.