Public Health Interventions For The Control Of Group A Streptococcal Disease And Scabies In Endemic Populations
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
The bacterium Group A Streptococcus (GAS) is an important cause of morbidity and mortality globally. The skin infestation scabies is an important portal of entry for GAS because it predisposes to skin sores. I propose to develop two research programs aimed at controlling these diseases: one is development of GAS vaccines and the other is investigating population-based interventions for control of scabies and related GAS skin infection.
Group A streptococcal diseases, including rheumatic heart disease, are major causes of illness globally, mostly in developing countries. This proposal is an investigation into how best to tackle control these diseases. It focuses on 1) a novel way to detect rheumatic heart disease in its earliest phases using ultrasound, 2) using a single drug once per year to stop streptococcal skin sores by controlling scabies infestation in whole communities and 3) developing a new vaccine that is applicable ....Group A streptococcal diseases, including rheumatic heart disease, are major causes of illness globally, mostly in developing countries. This proposal is an investigation into how best to tackle control these diseases. It focuses on 1) a novel way to detect rheumatic heart disease in its earliest phases using ultrasound, 2) using a single drug once per year to stop streptococcal skin sores by controlling scabies infestation in whole communities and 3) developing a new vaccine that is applicable across all regions of the world.Read moreRead less
Towards The Elimination Of Tuberculosis And Rheumatic Heart Disease In Northern Australia And Our Region
Funder
National Health and Medical Research Council
Funding Amount
$258,600.00
Summary
My research program addresses tuberculosis and rheumatic heart disease, which are leading challenges for Northern Australia and our region. Both are diseases caused by infections with long-term complications. They cause illness and death in young Aboriginal people and neighbouring Southeast Asian populations. There are many gaps in our ability to effectively detect and prevent these diseases. My research targets these gaps, from cutting-edge science to translation of guidelines into practice.
Impact Of Pneumococcal Vaccination And Environmental Factors On Pneumococcal Carriage And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$455,872.00
Summary
Pneumonia is the leading killer of children <5y of age worldwide, and the pneumococcal bacterium is a common cause. Pneumococci are carried in the noses of healthy children. In this project we will determine 1) whether carriage can be used to monitor the impact of vaccination in resource-poor settings, 2) the effect of new vaccines on ear disease and transmission using infant mouse models and 3) if exposure to smoke effects the ability of pneumococci to cause disease and altered gene expressi ....Pneumonia is the leading killer of children <5y of age worldwide, and the pneumococcal bacterium is a common cause. Pneumococci are carried in the noses of healthy children. In this project we will determine 1) whether carriage can be used to monitor the impact of vaccination in resource-poor settings, 2) the effect of new vaccines on ear disease and transmission using infant mouse models and 3) if exposure to smoke effects the ability of pneumococci to cause disease and altered gene expression.Read moreRead less
Evaluation And Optimisation Of Paediatric Vaccination Programs In Australia And The Region
Funder
National Health and Medical Research Council
Funding Amount
$293,426.00
Summary
Vaccines are highly effective in preventing infection. Increasing numbers of vaccines are available to children and to national immunisation programs. Research is required to ensure that vaccines included in national programs are effective and safe. We must also understand why some children are not vaccinated and to assess ways to improve uptake. Focusing on two common disease, influenza and pneumococcal disease, this fellowship will address these unanswered questions.
Understanding And Modulating Hyperinflammation Caused By Influenza Viruses
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
In humans, highly pathogenic influenza A virus (IAV) infections can be fatal, as the disease is untreatable with available vaccine or anti-viral drugs. My fellowship aims to advance our knowledge of the mechanisms by which the immune system induces and regulates inflammation during IAV infection, which can be both helpful and detrimental in fighting the infection. This is critical for identifying and developing new therapies for severe IAV infections in the future.