Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be app ....Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be applied to very early detection of tumours. To overcome this short-coming the next generation of imaging probes will be developed, which will require fundamental investigations in polymer and nanomaterials science to maximise imaging sensitivity and extend probe functionality. Successful outcomes will lead to significant benefits to healthcare in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100800
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Polymer micropatches applied to the skin for integrated capture and detection of circulating biomarkers. The purpose of this project is to develop a rapid and integrated technology for user-friendly biomarker detection at the point-of-care. We expect the device to rapidly detect proteins and/or antibodies, without the need for highly trained health workers or access to scientific laboratories.
Cryptographic Protocols: Proofs and Designs. Cryptographic protocols are the foundation for protection of the critical electronic communications infrastructure on which much of commerce and industry rely. They will increasingly be required in emerging technologies such as ad-hoc wireless networks and sensor networks. This project will provide the ability to design new and efficient protocols with a mathematical guarantee of security. The resulting practical protocols will benefit all users of el ....Cryptographic Protocols: Proofs and Designs. Cryptographic protocols are the foundation for protection of the critical electronic communications infrastructure on which much of commerce and industry rely. They will increasingly be required in emerging technologies such as ad-hoc wireless networks and sensor networks. This project will provide the ability to design new and efficient protocols with a mathematical guarantee of security. The resulting practical protocols will benefit all users of electronic communications who require security for their information. This includes the financial industries, government, commerce and domestic users.Read moreRead less
Cryptographic Protocols from Pairings: Proofs and Designs. Modern society has become critically dependent on information and communications infrastructures. At the same time, the development of e-commerce is being slowed by lack of confidence in its security. By providing increased assurance and enhanced cryptographic security protocols this research will improve the dependability of the nation's information and communications infrastructure, as well as encourage the growth of e-commerce. Throu ....Cryptographic Protocols from Pairings: Proofs and Designs. Modern society has become critically dependent on information and communications infrastructures. At the same time, the development of e-commerce is being slowed by lack of confidence in its security. By providing increased assurance and enhanced cryptographic security protocols this research will improve the dependability of the nation's information and communications infrastructure, as well as encourage the growth of e-commerce. Through the expertise and experience gained with this project, Australia's excellence in information security research will be reinforced. The training of PhD and Honours students will provide a much needed source of highly trained information security professionals.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101056
Funder
Australian Research Council
Funding Amount
$380,156.00
Summary
Rational Design of Plasmonic Nanoassemblies for Rapid and Multiplexed Point-of-Care Diagnosis by Surface-enhanced Raman Spectroscopy (SERS). The central aim of this project is to develop a novel technology/sensor platform for rapid, quantitative, multiplexed and highly sensitive point-of-care diagnostics using surface-enhanced Raman spectroscopy (SERS) as the read-out approach. Three-dimensional plasmonic superstructures as novel SERS labels will be synthesised and characterised at single-partic ....Rational Design of Plasmonic Nanoassemblies for Rapid and Multiplexed Point-of-Care Diagnosis by Surface-enhanced Raman Spectroscopy (SERS). The central aim of this project is to develop a novel technology/sensor platform for rapid, quantitative, multiplexed and highly sensitive point-of-care diagnostics using surface-enhanced Raman spectroscopy (SERS) as the read-out approach. Three-dimensional plasmonic superstructures as novel SERS labels will be synthesised and characterised at single-particle level and the choice of optimal SERS-active three-dimensional superstructures for use will be guided by empirical structure-activity correlations in combination with computer simulations. Tumour biomarkers for breast cancer will be employed as the model target for establishing the detection platform in a portable configuration for point-of-care diagnostics.Read moreRead less
Practical Identity-Based Cryptography: Efficient and Secure Elliptic Curve Pairings. Bilinear pairings on elliptic curves are a new cryptographic tool and allow novel and improved applications in information security. For example, they have been proposed as a substitute of existing public key infrastructures, an essential element in electronic commerce and a secure Internet. The research will lead to an increase in fundamental knowledge in the area of practical implementation and secure applic ....Practical Identity-Based Cryptography: Efficient and Secure Elliptic Curve Pairings. Bilinear pairings on elliptic curves are a new cryptographic tool and allow novel and improved applications in information security. For example, they have been proposed as a substitute of existing public key infrastructures, an essential element in electronic commerce and a secure Internet. The research will lead to an increase in fundamental knowledge in the area of practical implementation and secure applications of pairings. The results will benefit all users of electronic communications who require security for their information. This includes the financial industries, government, commerce and domestic users. It will also support many new product opportunities aligned with Motorola's business markets.Read moreRead less
Dendrimers: multidimensional sensors. The threat of terrorism is presented to us on a daily basis. Although there is often talk of dirty bombs, and biological and nuclear terrorism, the most easily sourced weapon of the terrorist is still the conventional explosive. As such the ability to detect trace amounts of compounds such as TNT or Semtex is required. This means that there is a real need for a portable detection system with the ability to reliably sense a specific explosive, selectively at ....Dendrimers: multidimensional sensors. The threat of terrorism is presented to us on a daily basis. Although there is often talk of dirty bombs, and biological and nuclear terrorism, the most easily sourced weapon of the terrorist is still the conventional explosive. As such the ability to detect trace amounts of compounds such as TNT or Semtex is required. This means that there is a real need for a portable detection system with the ability to reliably sense a specific explosive, selectively at low concentrations. This project concerns the development of new sensors that have potential to increase the nation's security.Read moreRead less
High throughput engineering of genetically encodable fluorescent sensors of intracellular signalling networks. Understanding of biochemical processes in living organisms is central to biological research and drug discovery. At present, the field suffers from a chronic paucity of adequate observation methods. The proposed project represents an interdisciplinary effort to create approaches for real-time monitoring of complex cellular chemistries. This work will deliver novel technologies for use i ....High throughput engineering of genetically encodable fluorescent sensors of intracellular signalling networks. Understanding of biochemical processes in living organisms is central to biological research and drug discovery. At present, the field suffers from a chronic paucity of adequate observation methods. The proposed project represents an interdisciplinary effort to create approaches for real-time monitoring of complex cellular chemistries. This work will deliver novel technologies for use in diagnostics and drug development. It will provide vital information on the changes in cellular processes induced by malignant transformation, viral infection and aging. This work will generate both health and economic benefits for the community and have a positive impact on the international visibility of Australian biomedical research.Read moreRead less
Advanced Stability Sensor for Anaerobic Digestion Processes. Australia is firmly committed to energy reduction and production, where possible, renewable energy production. Anaerobic digestion is the only in-use wastewater treatment option that not only can have net zero energy consumption, but that actually produces energy. This energy is from renewable carbon sources is therefore a zero contributor to greenhouse gases. Australia has some of the strongest environmental limit laws in the world. ....Advanced Stability Sensor for Anaerobic Digestion Processes. Australia is firmly committed to energy reduction and production, where possible, renewable energy production. Anaerobic digestion is the only in-use wastewater treatment option that not only can have net zero energy consumption, but that actually produces energy. This energy is from renewable carbon sources is therefore a zero contributor to greenhouse gases. Australia has some of the strongest environmental limit laws in the world. While this is reasonable - given our sensitive environment -assisting industry in meeting those limits in a cost effective manner is a priority. Given sufficient process stability and transparency, anaerobic digestion is a low capital and operating cost option. Read moreRead less
Efficient and Secure Word-Based Stream Ciphers for Wireless Communications. Wireless networks are increasingly being used for communication, and to manage and control Australia's critical infrastructure. However, current methods of securing wireless networks are flawed, putting the country's economy, environment, and citizens at risk. The most reliable method for protecting wireless communications requires secure and efficient encryption algorithms. However, flaws have been found in most algo ....Efficient and Secure Word-Based Stream Ciphers for Wireless Communications. Wireless networks are increasingly being used for communication, and to manage and control Australia's critical infrastructure. However, current methods of securing wireless networks are flawed, putting the country's economy, environment, and citizens at risk. The most reliable method for protecting wireless communications requires secure and efficient encryption algorithms. However, flaws have been found in most algorithms proposed to date. This project will examine existing algorithms and attacks to determine design criteria for secure encryption algorithms for use in a wireless environment. An algorithm which meets these criteria and can be implemented efficiently in hardware and software will be proposed.Read moreRead less