Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be app ....Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be applied to very early detection of tumours. To overcome this short-coming the next generation of imaging probes will be developed, which will require fundamental investigations in polymer and nanomaterials science to maximise imaging sensitivity and extend probe functionality. Successful outcomes will lead to significant benefits to healthcare in Australia.Read moreRead less
Dendrimers: multidimensional sensors. The threat of terrorism is presented to us on a daily basis. Although there is often talk of dirty bombs, and biological and nuclear terrorism, the most easily sourced weapon of the terrorist is still the conventional explosive. As such the ability to detect trace amounts of compounds such as TNT or Semtex is required. This means that there is a real need for a portable detection system with the ability to reliably sense a specific explosive, selectively at ....Dendrimers: multidimensional sensors. The threat of terrorism is presented to us on a daily basis. Although there is often talk of dirty bombs, and biological and nuclear terrorism, the most easily sourced weapon of the terrorist is still the conventional explosive. As such the ability to detect trace amounts of compounds such as TNT or Semtex is required. This means that there is a real need for a portable detection system with the ability to reliably sense a specific explosive, selectively at low concentrations. This project concerns the development of new sensors that have potential to increase the nation's security.Read moreRead less
High throughput engineering of genetically encodable fluorescent sensors of intracellular signalling networks. Understanding of biochemical processes in living organisms is central to biological research and drug discovery. At present, the field suffers from a chronic paucity of adequate observation methods. The proposed project represents an interdisciplinary effort to create approaches for real-time monitoring of complex cellular chemistries. This work will deliver novel technologies for use i ....High throughput engineering of genetically encodable fluorescent sensors of intracellular signalling networks. Understanding of biochemical processes in living organisms is central to biological research and drug discovery. At present, the field suffers from a chronic paucity of adequate observation methods. The proposed project represents an interdisciplinary effort to create approaches for real-time monitoring of complex cellular chemistries. This work will deliver novel technologies for use in diagnostics and drug development. It will provide vital information on the changes in cellular processes induced by malignant transformation, viral infection and aging. This work will generate both health and economic benefits for the community and have a positive impact on the international visibility of Australian biomedical research.Read moreRead less
From dust to planets: New initiatives to refine models of the inner Solar System's earliest history. This project will help continue the proud tradition of Australia as an international leader in mass spectrometric analyses and cosmochemistry. The questions surrounding the origin and significance of terrestrial planets are closely related to our very presence: "Are we alone"?
Research into meteorites is one of the few areas of science that truly captures the imagination of the general public. T ....From dust to planets: New initiatives to refine models of the inner Solar System's earliest history. This project will help continue the proud tradition of Australia as an international leader in mass spectrometric analyses and cosmochemistry. The questions surrounding the origin and significance of terrestrial planets are closely related to our very presence: "Are we alone"?
Research into meteorites is one of the few areas of science that truly captures the imagination of the general public. This project, through its integration with the WA Museum, gives the public a possibility to share in this experience.Read moreRead less
Development and structural characterisation of carbide-derived carbon membranes and their application in separation. This research addresses a key challenge in gas separation crucial to our energy future and environmental sustainability, while harnessing the potential of carbide derived carbons. The project has a multitude of benefits for Australia, not only because it contributes to on-going research on carbon dioxide sequestration and utilization of alternate fuels, but because it will see a n ....Development and structural characterisation of carbide-derived carbon membranes and their application in separation. This research addresses a key challenge in gas separation crucial to our energy future and environmental sustainability, while harnessing the potential of carbide derived carbons. The project has a multitude of benefits for Australia, not only because it contributes to on-going research on carbon dioxide sequestration and utilization of alternate fuels, but because it will see a new generation of Australian researchers trained in multidisciplinary cutting-edge research while addressing several areas of national priority, including reducing emissions, breakthrough sciences, development of frontier technologies and advanced materials, and thereby creating new opportunities for industry.Read moreRead less
Development of a neutral helium beam microscope. This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field. The project will develop a prototype instrument which is aimed at becoming a commercial ....Development of a neutral helium beam microscope. This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field. The project will develop a prototype instrument which is aimed at becoming a commercially viable product - the neutral helium beam microscope. The possibilities of using the microscope system as a nanofabrication device would also give researchers in Australia the ability to fabricate structures that could not be manufactured anywhere else in the world.Read moreRead less
New Methods in the Theory and Computational Modelling of Unimolecular and Complex-Forming Bimolecular Reactions. This project will develop new theory and computational methods for the prediction of chemical reaction rates with massively increased efficiency. Complex reactions occurring in combustion which are surprisingly common, but have previously been only poorly understood. The project will make possible the application of detailed statistical and quantum dynamical theories to such complex r ....New Methods in the Theory and Computational Modelling of Unimolecular and Complex-Forming Bimolecular Reactions. This project will develop new theory and computational methods for the prediction of chemical reaction rates with massively increased efficiency. Complex reactions occurring in combustion which are surprisingly common, but have previously been only poorly understood. The project will make possible the application of detailed statistical and quantum dynamical theories to such complex reactions in order to improve the quality of chemical data which is used for modelling atmospheric change and pollution.
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Protein And Peptide Alpha Turns. All life is controlled by the structures and functions of proteins. Major components of proteins are alpha helices that are combinations of alpha turns. Different types of alpha turns exist in proteins but have not been well studied. This project will discover and classify alpha turns in proteins, create the first small molecules that contain alpha turns outside of complex protein environments, and provide a better understanding of their chemical, structural and ....Protein And Peptide Alpha Turns. All life is controlled by the structures and functions of proteins. Major components of proteins are alpha helices that are combinations of alpha turns. Different types of alpha turns exist in proteins but have not been well studied. This project will discover and classify alpha turns in proteins, create the first small molecules that contain alpha turns outside of complex protein environments, and provide a better understanding of their chemical, structural and biological properties. Results will teach scientists important details about protein structure and function, train scientists at a frontier of chemistry-biology research, and may contribute to national priorities by triggering new approaches to medicines and novel materials.Read moreRead less
The molecular biology and biochemistry of bacterial manganese oxidation. This project will further the understanding of bacterial manganese (Mn2+) oxidation. A multi-disciplinary approach will be used to further investigate the genetics and biochemistry of the Mn2+-oxidising systems of Pseudomonas putida, Leptothrix sp. and Pedomicrobium sp. This work will focus in particular on comparing the Mn2+-oxidising systems from unrelated bacteria. A combination of molecular biology, protein biochemis ....The molecular biology and biochemistry of bacterial manganese oxidation. This project will further the understanding of bacterial manganese (Mn2+) oxidation. A multi-disciplinary approach will be used to further investigate the genetics and biochemistry of the Mn2+-oxidising systems of Pseudomonas putida, Leptothrix sp. and Pedomicrobium sp. This work will focus in particular on comparing the Mn2+-oxidising systems from unrelated bacteria. A combination of molecular biology, protein biochemistry and spectroscopy will be used. This will be the first time that the enzymes of bacterial Mn2+-oxidation will have been characterised in such detail and will lead to a greater understanding of the process of bacterial manganese oxidation.Read moreRead less
Function, Mechanism and Dynamics in Fluorescent Proteins: a Computational Investigation. The rich reservoir of chromoproteins and fluorescent proteins in the ecosystem of the Great Barrier Reef offers Australia a unique natural advantage for the development of a niche biotechnology industry based on fluorescent markers for cellular biology and biomedical imaging. This project provides a crucial component of the science that is necessary for developing such an industry: a molecular-level knowledg ....Function, Mechanism and Dynamics in Fluorescent Proteins: a Computational Investigation. The rich reservoir of chromoproteins and fluorescent proteins in the ecosystem of the Great Barrier Reef offers Australia a unique natural advantage for the development of a niche biotechnology industry based on fluorescent markers for cellular biology and biomedical imaging. This project provides a crucial component of the science that is necessary for developing such an industry: a molecular-level knowledge of how these proteins function and how we can manipulate and enhance their properties as imaging agents. It will achieve fundamental advances in biomolecular modelling techniques, train graduates with exceedingly valuable skill sets as well as deriving knowledge that aids the development of Australia's biotech industries.Read moreRead less