An Australasian, Multi-centre, Randomized, Double-blind, Placebo-controlled Trial Of The Efficacy Of Fluoxetine In Improving Functional Recovery After Acute Stroke
Funder
National Health and Medical Research Council
Funding Amount
$2,306,367.00
Summary
Stroke is one of the top three causes of disability. Treatments that improve recovery after stroke are lacking. We reviewed the world literature and found a number of very small studies which, together, suggest that the antidepressant drug, fluoxetine, may improve the recovery in stroke patients. AFFINITY is a large trial in 1600 Australians and New Zealanders with stroke which aims to find out whether taking fluoxetine for 6 months after a stroke improves recovery compared to a placebo.
A Quantitative Analysis of Prawn Harvesting Strategies. Prawn fisheries in NSW are undergoing major changes in their management. This unusual PhD project will design and test new decision-rules and strategies for fishery managers that are based upon pragmatic quantities of catch-per-unit-effort, prawn size, and river temperature and discharge. The performance of rules and strategies will be measured to ensure that they generate satisfactory outcomes for the prawn resources and the people that de ....A Quantitative Analysis of Prawn Harvesting Strategies. Prawn fisheries in NSW are undergoing major changes in their management. This unusual PhD project will design and test new decision-rules and strategies for fishery managers that are based upon pragmatic quantities of catch-per-unit-effort, prawn size, and river temperature and discharge. The performance of rules and strategies will be measured to ensure that they generate satisfactory outcomes for the prawn resources and the people that depend upon them. A major outcome will be precautionary or risk-averse decision-rules and strategies that are robust to the uncertainties that exist in prawn fisheries.Read moreRead less
Testing the Flood Pulse Concept for rivers with variable flow regimes. For floodplain rivers the major unifying conceptual model linking hydrology, biogeochemistry and ecology is the Flood Pulse Concept (FPC). The model is based on rivers that have a seasonally predictable and long duration inundation of floodplain habitats. Recent reviews of the FPC indicate that the model needs to be broadened to describe the function of rivers with more variable flow regimes. This project will test some of th ....Testing the Flood Pulse Concept for rivers with variable flow regimes. For floodplain rivers the major unifying conceptual model linking hydrology, biogeochemistry and ecology is the Flood Pulse Concept (FPC). The model is based on rivers that have a seasonally predictable and long duration inundation of floodplain habitats. Recent reviews of the FPC indicate that the model needs to be broadened to describe the function of rivers with more variable flow regimes. This project will test some of the predictions of the FPC for variable dryland rivers by investigating how food webs in the channels of a floodplain reach respond to flows of different magnitude, seasonal timing and duration.Read moreRead less
Establishing an ecological basis for stocking density of Australian bass in freshwaters: Experimental field tests of a general numerical model. Large numbers of the Australian public go fishing, particularly in rivers and impoundments. Angling in these waterways provides a strong source of income for rural and regional communities. The stocking of native fish to support inland angling also sustains much of the aquaculture industry in western NSW and Queensland. This study will develop an optimal ....Establishing an ecological basis for stocking density of Australian bass in freshwaters: Experimental field tests of a general numerical model. Large numbers of the Australian public go fishing, particularly in rivers and impoundments. Angling in these waterways provides a strong source of income for rural and regional communities. The stocking of native fish to support inland angling also sustains much of the aquaculture industry in western NSW and Queensland. This study will develop an optimal approach to stocking Australian bass which is relevant for other stocked freshwater species, and will allow stocking to be undertaken in an environmentally responsible manner. This will both enhance the outcome of investment of public funds in stocking, and enhance the recreational fishing experience that is so important to rural regional communities.Read moreRead less
Fine-scale responses of freshwater fish to environmental flows in arid-zone rivers and wetlands. The community is demanding that river health be improved to sustainable levels through increased river flows. This will come through the efficient use of available environmental water that supports the ecology of Australia's river systems. This project will substantially inform the operational management of water for native fish populations and other organisms to specific wetlands and will guide the ....Fine-scale responses of freshwater fish to environmental flows in arid-zone rivers and wetlands. The community is demanding that river health be improved to sustainable levels through increased river flows. This will come through the efficient use of available environmental water that supports the ecology of Australia's river systems. This project will substantially inform the operational management of water for native fish populations and other organisms to specific wetlands and will guide the delivery of environmental flows to maintain native fish stocks. The project will help management of declining fish populations and more generally wetlands by improving our understanding of the role of environmental flows.Read moreRead less
Surplus baitfish? The consumption and bioenergetics of a predatory fish. This project aims to improve fisheries management of economically important baitfish by increasing our understanding of the ecosystem demand of predatory fish. The ecosystem demand of predatory fish is currently not understood, because it fails to include the considerable impact of juvenile fish, especially when they reside in an estuary. The project intends to implant acoustic transmitters, calibrated in a flume, to discov ....Surplus baitfish? The consumption and bioenergetics of a predatory fish. This project aims to improve fisheries management of economically important baitfish by increasing our understanding of the ecosystem demand of predatory fish. The ecosystem demand of predatory fish is currently not understood, because it fails to include the considerable impact of juvenile fish, especially when they reside in an estuary. The project intends to implant acoustic transmitters, calibrated in a flume, to discover bioenergetic rates in the field by determining the diet and the size- and temperature-dependent growth and biogenetics of a predatory fish species, from juvenile to adult, from estuary to the open sea. The outcomes include an ecosystem synthesis of related pelagic fish predators from catchment to coast.Read moreRead less
Ecological impacts of QX Oyster disease and its management strategies. QX disease is responsible for mass mortality of oysters, and, as a result, economic and job losses. QX disease also threatens ecosystem services provided by wild oysters, such as biodiversity enhancement and fish production. This project will provide estuarine managers with information about how proposed QX management solutions will impact wild oyster populations and vital ecosystem services. It will also contribute to traini ....Ecological impacts of QX Oyster disease and its management strategies. QX disease is responsible for mass mortality of oysters, and, as a result, economic and job losses. QX disease also threatens ecosystem services provided by wild oysters, such as biodiversity enhancement and fish production. This project will provide estuarine managers with information about how proposed QX management solutions will impact wild oyster populations and vital ecosystem services. It will also contribute to training of early career researchers in strategies to ensure the sustainable use of Australia's biodiversity. As QX outbreaks appear to be increasing, this research and training is urgently needed to underpin management to ensure long-term sustainability of valuable estuarine resources.Read moreRead less
Living on the edge: settlement dynamics of reef fishes across their ranges. Settlement and early establishment (recruitment) are major determinants of population viability of marine organisms, and can vary greatly among oceans and latitudes. We will compare the recruitment dynamics of populations of reef fishes across their range, including at range boundaries where populations may be more vulnerable to environmental impact. We will test the hypothesis that a combination of highly erratic sett ....Living on the edge: settlement dynamics of reef fishes across their ranges. Settlement and early establishment (recruitment) are major determinants of population viability of marine organisms, and can vary greatly among oceans and latitudes. We will compare the recruitment dynamics of populations of reef fishes across their range, including at range boundaries where populations may be more vulnerable to environmental impact. We will test the hypothesis that a combination of highly erratic settlement, poor physiological condition of incoming larvae, and poor recruit growth and survivorship will occur at range boundaries. Outcomes of the study will help in prediction of the viability of fish populations which will improve their management and protection.Read moreRead less