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NCE Based Strategy For Nuclear Reprogramming And Regenerative Medicine
Funder
National Health and Medical Research Council
Summary
Induced pluripotent stem cells (iPSCs) can be made by reprogramming adult cells. These cells can become any cell type in the human body. We can now create patient specific cells that may restore function in patients and not be rejected by their immune system. However, current methods for making iPSCs are slow, inefficient and have some safety concerns. This project aims to overcome these issues by using new chemical entities to reprogram cells that may be used for tissue repair and regeneration.
Reprogramming is the conversion of any cell into induced pluripotent stem cells (iPSC). iPSC carry immense clinical potential as they are pluripotent and can hence form any cell of the human body, however, they can also form tumours. We have identified a cell type during reprogramming which is pluripotent but cannot form tumours. It is the aim of this project to determine the molecular differences between iPSC and this cell type in order to facilitate the delivery of cell replacement therapies.
Characterising The Mechanisms That Control Blood Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$335,616.00
Summary
Hematopoiesis is a tightly regulated process that provides the body with a constant supply of all the cells of the blood system. My studies aim to characterize the molecular mechanisms that regulate the expansion and differentiation of hematopoietic stem cells (HSCs) into each cell lineage. These studies will be key to the effective use of cellular transplantation therapeutic strategies and aim to provide a greater understanding of the mechanisms that underpin proliferative disorders such as can ....Hematopoiesis is a tightly regulated process that provides the body with a constant supply of all the cells of the blood system. My studies aim to characterize the molecular mechanisms that regulate the expansion and differentiation of hematopoietic stem cells (HSCs) into each cell lineage. These studies will be key to the effective use of cellular transplantation therapeutic strategies and aim to provide a greater understanding of the mechanisms that underpin proliferative disorders such as cancer.Read moreRead less
Enhanced Vascularisation And Growth Of Stem Cell Derived Human Myocardial Grafts
Funder
National Health and Medical Research Council
Funding Amount
$382,346.00
Summary
300 000 Australians currently have heart failure with 400 new cases weekly. New therapies are urgently needed. We can now create heart muscle grafts that can be transplanted after ñheart attackî but graft survival in this hostile environment is low. This project will investigate use of different combinations of human cell types that will cooperate together to improve survival/function of heart muscle grafts, advancing this promising strategy towards being a viable new treatment for heart failure
The behaviour of prostate cancer cells is regulated by their surrounding environment known as the stroma. The stroma has been proposed as a therapeutic target, but it is a diverse mix of cells that needs to be specifically targeted. Not all stromal cells are equal; cells surrounding tumours have different features from cells in normal tissue. Therefore, the goal of this project is to directly isolate cancer-associated stromal cells from patient tissue and study their role in cancer progression.
Smart Synthetic Biomaterial Provides An Appropriate Microenvironment For Bone Tissue Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$337,946.00
Summary
The demand for synthetic biomaterials to repair lost or diseased bone is rapidly growing and placing a major burden on national health budgets. But the synthetic scaffolds currently in use are far from optimal. My aim is to determine the underlying mechanisms by which synthetic biomaterials promote bone regeneration, in order to develop better scaffolds. This would improve health outcomes for recipients of bone graft substitutes as well as reduce individual and national healthcare costs.
Smart Hybrid Material For Cartilage Tissue Engineering
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
Tissue engineering is a promising approach to repair damaged/degenerated cartilage caused by various diseases or injuries. Because of its limited capacity for self repair cartilage becomes a constriant to normal everyday life once degenerated. This project aims to develop composite polymers for cartilage repair. The potential of this newly developed material for cartilage tissue engineering will be investigated through the material and biological characterisation techniques.