Altered Protein Secretion Links The Fatty Liver To Metabolic Disease
Funder
National Health and Medical Research Council
Funding Amount
$415,797.00
Summary
The liver secretes proteins to alter metabolism in other tissues of the body. Fatty liver is a major feature of obesity and type 2 diabetes. This project aims to understand how fatty liver changes protein secretion and how this impacts on metabolic processes. The outcomes of this project will be the identification of protein biomarkers of fatty liver and the prediction of insulin resistance development in other tissues of the body.
The Alternate Renin Angiotensin System; A Novel Target For The Prevention And Treatment Of Liver Fibrosis And Portal Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$693,950.00
Summary
Cirrhosis of the liver due to chronic hepatitis and other common liver diseases is now a major cause of illness and death in Australia. This project will examine how a hormone system called the renin angiotensin system contributes to the development of liver damage in these diseases. We will study whether drugs targeting this system can be used to reduce liver scarring and prevent the development of cirrhosis and its complications.
IC7: A Gp130 Receptor Ligand To Treat Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$598,833.00
Summary
Over the past decade work from our group has identified that a group of proteins, termed gp130 receptor cytokines, can lead to improvements in both causes and symptoms of type 2 diabetes in both animals and humans. Unfortunately, due to side effects, clinical trial using analogues of these proteins have failed. We believe we know why this is the case and we now have developed new, improved peptides that should overcome these side effects. We hope that we have created a novel drug that will help ....Over the past decade work from our group has identified that a group of proteins, termed gp130 receptor cytokines, can lead to improvements in both causes and symptoms of type 2 diabetes in both animals and humans. Unfortunately, due to side effects, clinical trial using analogues of these proteins have failed. We believe we know why this is the case and we now have developed new, improved peptides that should overcome these side effects. We hope that we have created a novel drug that will help treat type 2 diabetes.Read moreRead less