Statistical and computational methods using a multiscale approach for protein identification and quantification. Proteins are critically important in the onset and ongoing illness associated with disease. Key proteins may serve as markers to diagnose or predict the course of a disease, or even become the target of pharmaceuticals. Accurate, efficient and robust algorithms are a critical component in protein identification. This research provides novel statistical algorithms for protein identific ....Statistical and computational methods using a multiscale approach for protein identification and quantification. Proteins are critically important in the onset and ongoing illness associated with disease. Key proteins may serve as markers to diagnose or predict the course of a disease, or even become the target of pharmaceuticals. Accurate, efficient and robust algorithms are a critical component in protein identification. This research provides novel statistical algorithms for protein identification using multiscale analysis techniques. Their applications in the bio-medical field will enable Australian and international researchers to identify key proteins more accurately, than current methods, leading to improve health, medical, and biological research outcomes.Read moreRead less
New statistical methods for identifying micro-ribonucleic acid (miRNA) regulatory networks. Understanding gene regulatory networks is critical in the understanding of fundamental biological systems. These networks have important implications for the discovery of fundamental mechanisms relating to the diagnosis and management of many illnesses. This research will provide new statistical methods to identify regulatory micro-ribonucleic acid modules and to understand their relationship in gene regu ....New statistical methods for identifying micro-ribonucleic acid (miRNA) regulatory networks. Understanding gene regulatory networks is critical in the understanding of fundamental biological systems. These networks have important implications for the discovery of fundamental mechanisms relating to the diagnosis and management of many illnesses. This research will provide new statistical methods to identify regulatory micro-ribonucleic acid modules and to understand their relationship in gene regulatory networks through multiple covariance estimation and multivariate classification techniques. My results should enable researchers to better understand the regulation underlying biological systems, leading to improved human health, medical and biological research outcomes.Read moreRead less
Dynamic prediction models in Australian rules football using real time performance statistics. The study is a collaborative venture with Champion Data, the Australian leader in the collection and transmission of real time sporting data, and official provider of the Australian Football League (AFL) statistics. The aim is to develop a real time on line predictive model for AFL football. The model will use the statistics Champion Data collect as the match progresses as inputs to continually updat ....Dynamic prediction models in Australian rules football using real time performance statistics. The study is a collaborative venture with Champion Data, the Australian leader in the collection and transmission of real time sporting data, and official provider of the Australian Football League (AFL) statistics. The aim is to develop a real time on line predictive model for AFL football. The model will use the statistics Champion Data collect as the match progresses as inputs to continually update estimates of the probabilities of various outcomes of interest such as the winner of the match and the margin of victory. The project will assist Champion in their strategic aim to provide an on line form guide.Read moreRead less
Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant ....Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant contributions to the new and evolving priority research area of Bioinformation Science (including bioinformatics). Outcomes will include novel techniques for analysis and mining of post-genome data, with applications to developments in Bio-medicine and Bio-agricultureRead moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100291
Funder
Australian Research Council
Funding Amount
$374,595.00
Summary
Adaptive control of stochastic queueing networks. Queues of items competing for service appear on the road, in health-care, in manufacturing and in communication systems. This project will set up methodology for adaptive control and resource allocation for stochastic queueing network models applicable to a variety of scenarios accounting for parameter uncertainty.
Attrition in longitudinal studies: advancing and evaluating statistical methods. Longitudinal studies are a vital tool for monitoring the health and well-being of Australians. They are uniquely placed to examine changes in diseases over time and prospectively collect data on exposure and disease onset. There have been many successful longitudinal studies in Australia that have lead to significant breakthroughs in evidence-based health (e.g. the Nambour Skin Cancer Prevention Trial). Unfortunatel ....Attrition in longitudinal studies: advancing and evaluating statistical methods. Longitudinal studies are a vital tool for monitoring the health and well-being of Australians. They are uniquely placed to examine changes in diseases over time and prospectively collect data on exposure and disease onset. There have been many successful longitudinal studies in Australia that have lead to significant breakthroughs in evidence-based health (e.g. the Nambour Skin Cancer Prevention Trial). Unfortunately all longitudinal studies suffer from attrition, or loss of participants, which leads to questions concerning their validity and generalisability. This project will investigate the causes of attrition, and the effect attrition has on longitudinal studies, in order to improve their design and analysis.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453501
Funder
Australian Research Council
Funding Amount
$406,097.00
Summary
A Computational Research Grid Serving Regional and Metropolitan Queensland. This project will advance scientific discovery through the development of an integrated, user-friendly computational grid. It significantly enhances Queensland's research capability and infrastructure by delivering state-of-the-art computational resources to researchers at the collaborating institutions and other Queensland and Australia researchers. New supercomputer systems will be integrated into a Queensland wide com ....A Computational Research Grid Serving Regional and Metropolitan Queensland. This project will advance scientific discovery through the development of an integrated, user-friendly computational grid. It significantly enhances Queensland's research capability and infrastructure by delivering state-of-the-art computational resources to researchers at the collaborating institutions and other Queensland and Australia researchers. New supercomputer systems will be integrated into a Queensland wide computational grid being developed by the Queensland Parallel Supercomputing Foundation - an initiative supported by the Queensland State Government. New grid technologies will be employed so that the highest level of support is provided to researchers. This ensures that the facility is used effectively, allowing high-quality research to be efficiently conducted.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101670
Funder
Australian Research Council
Funding Amount
$370,410.00
Summary
Scalable Bayesian model selection for massive data sets. This project will develop highly innovative, efficient and ultimately effective methodology for Bayesian model selection for large-scale problems which commonly arise in biostatistics and bioinformatics. The resulting methodology will dramatically reduce the duration of analyses in these areas from days or weeks to minutes or hours.
Discovery Early Career Researcher Award - Grant ID: DE170100748
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Statistical tools for assessing effects of environmental change. This project aims to develop statistical tools for improving prediction of environmental exceedances, such as atmospheric carbon dioxide sources and sinks. Predicting extreme environmental conditions or events is crucial for effective environmental decision-making and management. The project will develop the tools using statistical inference based on a statistical model that combines predictions from related scientific models. In t ....Statistical tools for assessing effects of environmental change. This project aims to develop statistical tools for improving prediction of environmental exceedances, such as atmospheric carbon dioxide sources and sinks. Predicting extreme environmental conditions or events is crucial for effective environmental decision-making and management. The project will develop the tools using statistical inference based on a statistical model that combines predictions from related scientific models. In the case of carbon dioxide, improving prediction reliability by reducing bias and uncertainty whilst accounting for model-based dependence is an important step toward mitigating carbon dioxide sources and protecting carbon dioxide sinks. This capability is crucial for adaptive planning and a resilient society.Read moreRead less