Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant ....Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant contributions to the new and evolving priority research area of Bioinformation Science (including bioinformatics). Outcomes will include novel techniques for analysis and mining of post-genome data, with applications to developments in Bio-medicine and Bio-agricultureRead moreRead less
Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The ....Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The proposed research will enhance Australia's reputation for developing novel quantitative techniques at the cutting edge of modern biology. The proposed project has a broad range of potential applications in biotechnology, particularly in the medical and agricultural industries.Read moreRead less
Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The futu ....Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The future development of 'personalized medicine' will rely upon understanding the function of human genes, as will progress in the agricultural sector. Rigorous statistical analysis and development of appropriate bioinformatic methods are crucial to biological sequence analysis in comparative genomics.Read moreRead less
Precise Atmospheric Density Correction Model Using Space Tracking Data for Accurate Debris Surveillance and Collision Warning. Our project will build new atmospheric density correction models (ADCMs) for accurate prediction of debris object and satellite orbits. This research will have tremendous impacts on realizing unaided debris laser ranging. An order of magnitude accuracy improvement to the ADCMs will lead to a significant breakthrough in space object tracking. The benefits of this research ....Precise Atmospheric Density Correction Model Using Space Tracking Data for Accurate Debris Surveillance and Collision Warning. Our project will build new atmospheric density correction models (ADCMs) for accurate prediction of debris object and satellite orbits. This research will have tremendous impacts on realizing unaided debris laser ranging. An order of magnitude accuracy improvement to the ADCMs will lead to a significant breakthrough in space object tracking. The benefits of this research are: it will put Australia in a leading position in the world on ADCM study; to maintain Australia's leading role in space surveillance and greatly enhanced operational capability & efficiency of Australian space tracking systems; and to contribute significantly to the space environment info management, e.g. accurate collision warning and space junk tracking.Read moreRead less
Increasing internet energy and cost efficiency by improving higher-layer protocols. Australians rely heavily on our telecommunications infrastructure due to our geographic dispersion. We are also very susceptible to climate change, given our reliance on agriculture. Information technology is consuming a rapidly increasing fraction of our power and our budget. This research will help to reverse both those trends, by finding novel and practical ways to use our infrastructure more efficiently, and ....Increasing internet energy and cost efficiency by improving higher-layer protocols. Australians rely heavily on our telecommunications infrastructure due to our geographic dispersion. We are also very susceptible to climate change, given our reliance on agriculture. Information technology is consuming a rapidly increasing fraction of our power and our budget. This research will help to reverse both those trends, by finding novel and practical ways to use our infrastructure more efficiently, and to minimise its energy use. This will enable the Australian telecommunications industry to provide better service (including to Australian industries and rural communities) at lower economic and environmental cost. This project will put Australia on the international stage as a leading contributor to energy-efficient internet technology.Read moreRead less
Fatigue Life Prediction of Nano-filler Modified Composites. The proposed project aims to study the behaviour and the failure mechanisms of polymer nanocomposites under cyclic loading. The outcomes of the project will make original contributions to our knowledge base on such materials. The mechanics modelling and statistical analysis of the prediction of fatigue life will provide a sound physical basis and a useful tool for any future improvement and optimisation of the composites to achieve bett ....Fatigue Life Prediction of Nano-filler Modified Composites. The proposed project aims to study the behaviour and the failure mechanisms of polymer nanocomposites under cyclic loading. The outcomes of the project will make original contributions to our knowledge base on such materials. The mechanics modelling and statistical analysis of the prediction of fatigue life will provide a sound physical basis and a useful tool for any future improvement and optimisation of the composites to achieve better reliability and integrity in their intended applications. This study will bring economic benefits to the end-users of advanced material technology including the Australian materials industries. Read moreRead less
ARC Research Network for Advanced Materials. Materials science/engineering is decidedly interdisciplinary, covering all science and impacting on all manufacturing industry. This network will promote interactions that do not usually occur between materials researchers and students across Australia and internationally from diverse disciplines. The scope is broadly based on advanced materials production, processing and properties but focused in four areas, involving: i) innovative structural/functi ....ARC Research Network for Advanced Materials. Materials science/engineering is decidedly interdisciplinary, covering all science and impacting on all manufacturing industry. This network will promote interactions that do not usually occur between materials researchers and students across Australia and internationally from diverse disciplines. The scope is broadly based on advanced materials production, processing and properties but focused in four areas, involving: i) innovative structural/functional materials, ii) high-tech IT/communications/sensing materials, iii) materials solutions for manufacturing, iv) materials for a sustainable Australia, and v) emerging materials technologies. Key programs will promote interdisciplinary workshops and early career researcher interactions.Read moreRead less
Special Research Initiatives - Grant ID: SR0354605
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Earth System Dynamics Network for a Sustainable Australia. Earth comprises systems of enormous complexity that sustain all life and control the distribution of mineral, energy and water resources. Thus understanding these dynamic systems provides the key to sustainable resource usage. The aim of The Earth System Dynamics Network is to facilitate scientific interactions through establishment of an earth and environmental sciences grid that links national and regional data assets with high per ....The Earth System Dynamics Network for a Sustainable Australia. Earth comprises systems of enormous complexity that sustain all life and control the distribution of mineral, energy and water resources. Thus understanding these dynamic systems provides the key to sustainable resource usage. The aim of The Earth System Dynamics Network is to facilitate scientific interactions through establishment of an earth and environmental sciences grid that links national and regional data assets with high performance computing through open sourced middleware. The result will be an unparalleled predictive capacity for complex Earth systems. The outcome will be confidence in the knowledge that underpins our decisions as stakeholders to keep Australia sustainable.Read moreRead less
Nano-machining of diamond-like carbon (DLC): Scientific basis and technical potential. Nanotechnology will be the basis for the next post-industrial revolution, and will be the main driver of future national economies. It is crucially important that at the very least Australia is a significant niche player in those developments. The project represents an effort to promote those goals.
Sustainable processes for next-generation surface coatings and core-shell nanoparticles based on biomolecular templating. Nanotechnology promises new materials with broad impact, yet our ability to manufacture complex nanomaterials using sustainable processes is very limited. This project will advance our knowledge of nanomaterial manufacture using inspiration from how complex materials are made in nature. This project will deliver next-generation surface coatings that are incredibly thin but st ....Sustainable processes for next-generation surface coatings and core-shell nanoparticles based on biomolecular templating. Nanotechnology promises new materials with broad impact, yet our ability to manufacture complex nanomaterials using sustainable processes is very limited. This project will advance our knowledge of nanomaterial manufacture using inspiration from how complex materials are made in nature. This project will deliver next-generation surface coatings that are incredibly thin but strong, and specialised nanoparticles made using biocompatible processes. The knowledge and methods developed will benefit the biotechnology and nanotechnology sectors, as well as research in soft-matter science, quantum computing, photonics and healthcare. The value proposition for innovation in these fields will increasingly rely on new nanomanufacturing approaches.Read moreRead less