Modelling mean and dispersion using fixed and random effects. The aims of the project are to develop methods for joint mean and dispersion modelling using fixed and random effects, in the generalized linear models context and for Gaussian longitudinal data. The significance is the more efficient, precise and appropriate analysis of data arising from many areas of application. The expected outcomes are therefore better methods of analysis, software to carry the analyses out, and potentially impor ....Modelling mean and dispersion using fixed and random effects. The aims of the project are to develop methods for joint mean and dispersion modelling using fixed and random effects, in the generalized linear models context and for Gaussian longitudinal data. The significance is the more efficient, precise and appropriate analysis of data arising from many areas of application. The expected outcomes are therefore better methods of analysis, software to carry the analyses out, and potentially important results in applications.Read moreRead less
Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Pr ....Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Project will develop novel designs for microarray experiments and focus on the advancement of topics crucial to Australia's success in technological research.
Read moreRead less
Saddlepoint approximation, likelihood analysis and ancestral graphs for strong and weak natural selection, genetic drift and population subdivision. Building new research strength in theoretical population genetics and related statistical techniques will enhance Australia's capability in harnessing the power of post-genomic information. Sophisticated statistical techniques that make smart use of genetic data are being developed in this project. The extent to which natural selection and migrati ....Saddlepoint approximation, likelihood analysis and ancestral graphs for strong and weak natural selection, genetic drift and population subdivision. Building new research strength in theoretical population genetics and related statistical techniques will enhance Australia's capability in harnessing the power of post-genomic information. Sophisticated statistical techniques that make smart use of genetic data are being developed in this project. The extent to which natural selection and migration affect current genetic polymorphism on a population level can be quantified using these new methods. New modeling provides a rigorous foundation with which to construct inference techniques currently beyond computational approaches to the data. Assessing selective effects on genetic mutations associated with human disease will be a consequence of this new statistical methodology.Read moreRead less
Higher Line Bundles in Geometry and Physics. This project seeks to develop a theory of geometric objects, `higher line bundles', which realise elements of higher dimensional cohomology groups. In particular this project will develop a theory of differential geometry for these objects, allowing one to interpret differential forms representing cohomology classes as the `curvature' of a higher line bundle. This will have applications in quantum field theory and string/brane theory.
Global aspects of dualities in String Theory in the presence of background fluxes. String Theory, known to the general public as the "Theory of Everything', is currently an extremely active area of research internationally. It has not only stimulated considerable interaction between mathematical physicists and mathematicians, but also increased public interest in science through television programs and books. Unfortunately, the majority of the Australian scientific community has not yet caught ....Global aspects of dualities in String Theory in the presence of background fluxes. String Theory, known to the general public as the "Theory of Everything', is currently an extremely active area of research internationally. It has not only stimulated considerable interaction between mathematical physicists and mathematicians, but also increased public interest in science through television programs and books. Unfortunately, the majority of the Australian scientific community has not yet caught up with these developments. Our recent papers, all published in premier journals in this field, have not only received widespread international attention but have also increased the profile of String Theory amongst Australia's mathematicians and mathematical physicists. The proposed project is expected to continue this trend.Read moreRead less
Twisted K-theory and its application to String Theory and Conformal Field Theory. String Theory is, at present, the only consistent theory of quantum gravity. Recently, twisted K-theory was proposed as the algebraic structure underlying the classification of D-branes, i.e. solitonic extended objects, in certain closed string backgrounds. In this project we aim to advance our understanding of the properties of twisted K-theory in the context of String Theory and Conformal Field Theory. The ult ....Twisted K-theory and its application to String Theory and Conformal Field Theory. String Theory is, at present, the only consistent theory of quantum gravity. Recently, twisted K-theory was proposed as the algebraic structure underlying the classification of D-branes, i.e. solitonic extended objects, in certain closed string backgrounds. In this project we aim to advance our understanding of the properties of twisted K-theory in the context of String Theory and Conformal Field Theory. The ultimate goal is to find the appropriate K-theory classifying D-branes in arbitrary closed string backgrounds or, similarly, classifying boundary Conformal Field Theories. It has already emerged that the K-theory of C*-algebras will play an important role.Read moreRead less
Dualities in String Theory and Conformal Field Theory in the context of the Geometric Langlands Program. The Langlands program ties together seemingly unrelated areas of Mathematics. Recently, in the context of the Geometric Langlands correspondence, novel connections with Theoretical Physics have emerged, thus becoming one of the most active areas of research in both Mathematics and Theoretical Physics. Australia has a number of world-renowned experts, including the two CI's, in various aspect ....Dualities in String Theory and Conformal Field Theory in the context of the Geometric Langlands Program. The Langlands program ties together seemingly unrelated areas of Mathematics. Recently, in the context of the Geometric Langlands correspondence, novel connections with Theoretical Physics have emerged, thus becoming one of the most active areas of research in both Mathematics and Theoretical Physics. Australia has a number of world-renowned experts, including the two CI's, in various aspects of the Langlands program, and is therefore well-placed to make seminal contributions. Being involved in these new developments is of crucial importance to the health of Mathematics and Theoretical Physics in Australia. An integral part of this proposal is student involvement and postgraduate training.Read moreRead less
Fractional analytic index theory. Atiyah-Singer index theory, for which M.F. Atiyah and I.M. Singer received the 2004 Abel Prize, has stimulated considerable interaction between mathematicians and mathematical physicists. An extension of this theory is Fractional Index Theory, co-invented by R.B. Melrose, I.M. Singer and myself, which has received international attention, having solved a fundamental open problem. A central aim in my research project is to extend our theory to elliptic boundary ....Fractional analytic index theory. Atiyah-Singer index theory, for which M.F. Atiyah and I.M. Singer received the 2004 Abel Prize, has stimulated considerable interaction between mathematicians and mathematical physicists. An extension of this theory is Fractional Index Theory, co-invented by R.B. Melrose, I.M. Singer and myself, which has received international attention, having solved a fundamental open problem. A central aim in my research project is to extend our theory to elliptic boundary value problems. I will assist beginners to navigate to the cutting edge of research through workshops, spring-schools and supervision. Benefits include the enhancement of Australia's position in the forefront of international research.Read moreRead less
New perspectives on computing methods for mathematical signal processing. This project determines how best to design computing methods for challenging demands in signal processing. The expected conceptual & algorithmic advances will have significant repercussions in a number of fields including optimal filtering theory and will contribute to applications ranging from bio-informatics to electrical engineering. The new techniques will allow development of software that will benefit Australian in ....New perspectives on computing methods for mathematical signal processing. This project determines how best to design computing methods for challenging demands in signal processing. The expected conceptual & algorithmic advances will have significant repercussions in a number of fields including optimal filtering theory and will contribute to applications ranging from bio-informatics to electrical engineering. The new techniques will allow development of software that will benefit Australian industries and technologies. The formation of a strong research team across four universities in Australia, USA and Japan will enhance our scientific standing in the international community and will place Australian researchers at the forefront of world-class research methods. Read moreRead less
Aggregating Generalised Stochastic Petri Nets for improved Performance Analysis. Australia's economy is very dependent on the operation of complex man-made systems. Important examples are telecommunication networks and services (e.g. the Internet), manufacturing plants, organisational processes, military logistics and transport systems (e.g. air traffic control). The performance of these systems is critical to their success. Thus being able to predict performance before systems are implemented i ....Aggregating Generalised Stochastic Petri Nets for improved Performance Analysis. Australia's economy is very dependent on the operation of complex man-made systems. Important examples are telecommunication networks and services (e.g. the Internet), manufacturing plants, organisational processes, military logistics and transport systems (e.g. air traffic control). The performance of these systems is critical to their success. Thus being able to predict performance before systems are implemented is very important in their design. This project will develop leading-edge performance analysis techniques and tools for an important class of practical systems. There is potential to commercialise the resulting tools and methodology and to transfer the expertise to industry.Read moreRead less