Discovery And Translation Of Disease Causing Mutations With Genomic And Transcriptomic Data
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
This proposal will develop and apply methods for the analysis of genetic data generated from family and cohort studies of collaborators to identify genetic risk loci for both neurogenetic disorders and infectious diseases, particularly malaria. The project will combine large-scale datasets of different types and across different species. This will require the development and application of multivariate statistical analysis methods suited to the data.
Constructing Control Samples For The Australian And Other Populations: Improving Power And False Positive Rates In The Next Generation Of Genetic Association Studies With A Focus On Controlling For Fine-scale Population Structure In DNA Sequence Data
Funder
National Health and Medical Research Council
Funding Amount
$283,447.00
Summary
Individuals who live near each other tend to be more similar genetically than individuals who live in different parts of the world. One reason is that they share more of their genetic ancestry. There can be very subtle differences in patterns of genetic variation even within countries. Accounting for these subtle differences can be important for studies of the genetic basis of diseases. We will develop novel statistical methods to control for these genetic differences in disease studies.
Methods And Software Tool For Complex Trait Analyses Using Multi-omics Data
Funder
National Health and Medical Research Council
Funding Amount
$573,999.00
Summary
This project aims to develop methods to disentangle the contribution of people’s difference in DNA sequence, DNA methylation, and gene expression to their difference in characteristics (including risks to diseases), and to utilise these information to predict disease risks of different people. This project also aims to develop a versatile and efficient computer software to implement the methods being proposed in this project, as well as all other commonly used methods in the research community.
Healthy Heart, Healthy Brain - Using Genetic Data To Investigate The Causal Relationship Between Cardiovascular And Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$191,261.00
Summary
There is growing evidence supporting a strong association between cardiovascular disease (CVD) with neurodegenerative disease. However, evidence from observational studies has been inconsistent. This project will use genetic data to investigate this link. The project outcomes may point to new avenues for research and prevention, whereby lifestyle modifications pharmaceutical interventions which decrease CVD might also hold promise for reducing the burden of neurodegenerative disease.
Genome-wide Association Studies Of Biomedical Traits And Endophenotypes For Complex Disease
Funder
National Health and Medical Research Council
Funding Amount
$295,804.00
Summary
The burden of common complex diseases, such as cardiovascular disease is substantial to the health care system. These diseases are caused by genes and environments as well as their interactions. The proposed project will identify genes affecting the susceptibility of individuals to complex diseases. Discovery of such genes will be important for their diagnosis, prevention and treatment and may serve as an important resource for future personalized medicine.
Immune-associated Genetic Variation And Autoimmune Disease.
Funder
National Health and Medical Research Council
Funding Amount
$1,346,721.00
Summary
Understanding the genes that underpin the immune system is vital for studying the causes and effects of diseases. In particular, autoimmune diseases are strongly associated with an individual having certain genetic types. We plan to develop methods to type immune-related genes very cheaply so they can be studied in very large samples. We will apply the methods we develop to genetic studies of psoriasis and multiple sclerosis, and make data and methods available to other scientists.
Investigating The Interplay Of Gene And Environment In Childhood And Adolescent Mental Health
Funder
National Health and Medical Research Council
Funding Amount
$386,298.00
Summary
Mental health and substance use disorders account for 60-70% of the overall disease burden among young Australians. This research aims to fully explore the gene-environment interplay in childhood and adolescent mental health. The potential outcomes of this research include: improved understanding of genetic and environmental architecture for single disorder, and the high comorbidity between disorders; guidance for personalised intervention based on one’s genetic background.
Finding Genetic Risk Markers For Endometrial And Other Cancers
Funder
National Health and Medical Research Council
Funding Amount
$370,668.00
Summary
Studies investigating thousands of genetic markers have revolutionised our understanding of genes involved in cancer. They have also shown that a single gene can be associated with multiple cancers. This project will discover new genes involved in endometrial cancer by detailed genetic analysis, and investigate the genetic similarities between endometrial cancer and different cancers. Results will improve the understanding of cancer and provide opportunity to discover future cancer treatments.